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001-es BibID:BIBFORM014321
Első szerző:Cserni Tamás (gyermeksebész)
Cím:Hydrostatic characteristics of the ileocolic valve and intussuscepted Nipple valves : an animal model / Cserni Tamás, Pap Szekeres József, Furka István, Németh Norbert, Józsa Tamás, Mikó Irén
Dátum:2005
ISSN:0894-1939
Megjegyzések:The ileocolic valve, in the dog, decelerates the passage of stools and prevents fecal reflux. A loss of anterograde resistance worsens the symptoms of short bowel syndrome. The absence of fecal reflux control enhances the risk of recurrence of Crohn's disease. The aim of the present study was to examine what length of intussusception-like nipple valve (INV) should be constructed in order to restore the hydrostatic characteristics of the normal ileocecal valve. The anterograde and retrograde hydrostatic resistances of INVs of different lengths (4, 5, 6, or 7 cm) were compared with those of the normal ileocolic valve by using a contrast enema and x-ray monitoring in a canine model. It was found that the 4-cm-long INV may be sufficient to achieve an appropriate antireflux efficacy (59.60 +/- 4.26 cm H(2)O) versus the ileocolic valve (25.80 +/- 4.92 cm H(2)O), but this does not furnish an anterograde resistance comparable to that of the normal ileocolic valve (10.70 +/- 1.15 cm H(2)O vs. 21.60 +/- 3.96 cm H(2)O). We found that the appropriate length of the INV with which the anterograde resistance of the ileocolic valve could be attained in our model was between 6 and 7 cm. Thus, the shortest possible constructed INV should be effective in clinical conditions such as Crohn's disease, but the recommended length in short bowel syndrome should be greater than this.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Journal Of Investigative Surgery. - 18 : 4 (2005), p. 185-191. -
További szerzők:Pap Szekeres József (1965-) (sebész) Furka István (1935-2021) (sebész, urológus, kutatóorvos) Németh Norbert (1975-) (kutatóorvos) Józsa Tamás (1969-) (gyermeksebész, urológus) Mikó Irén (1948-) (kutató sebész)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM014324
Első szerző:Németh Norbert (kutatóorvos)
Cím:Allopurinol prevents erythrocyte deformability impairing but not the hematological alterations after limb ischemia-reperfusion in rats / Németh Norbert, Lesznyák Tamás, Szokoly Miklós, Furka István, Mikó Irén
Dátum:2006
ISSN:0894-1939
Megjegyzések:The measurement of red blood cell deformability provides a possible method for detecting the effect of ischemia-reperfusion on erythrocytes. In our study the effect of 1-h ischemia-reperfusion with or without allopurinol pretreatment on hematological parameters and red blood cell deformability was investigated in a follow-up experiment of 26 male CD outbred rats that were subjected to unilateral hind-limb ischemia by microvascular clips on femoral vessels for 1 h (IR, n = 6), some rats received allopurinol pretreatment under the same conditions (50 mg/kg, AP + IR, n = 8), others were subjected to sham operation (n = 6), and the rest of animals served as control (n = 6). Measurement of erythrocyte deformability using a bulk filtrometer with special setting of cell suspension hematocrit (1%), and determination of hematological parameters were performed daily for one week. In the IR group, relative cell transit time increased significantly on postoperative days 1 and 2, which was not observed in the other groups. Settings for the measurement of erythrocyte deformability by reducing the blood sample volume gave the possibility of monitoring the resulting changes in rats. Mean corpuscular volume and hemoglobin, platelet count, and platelet volume were higher in the IR and AP + IR groups than in the other groups. In summary, short-term ischemia and reperfusion induced lower red blood cell deformability in the early postoperative period, which could be prevented by allopurinol pretreatment.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Journal Of Investigative Surgery. - 19 : 1 (2006), p. 47-56. -
További szerzők:Lesznyák Tamás Szokoly Miklós (sebész, traumatológus, kézsebész, oxyológus) Furka István (1935-2021) (sebész, urológus, kutatóorvos) Mikó Irén (1948-) (kutató sebész)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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