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001-es BibID:BIBFORM100160
035-os BibID:(WOS)000750946900001 (Scopus)85125531096
Első szerző:Drosos, George C.
Cím:EULAR recommendations for cardiovascular risk management in rheumatic and musculoskeletal diseases, including systemic lupus erythematosus and antiphospholipid syndrome / Drosos George C., Vedder Daisy, Houben Eline, Boekel Laura, Atzeni Fabiola, Badreh Sara, Boumpas Dimitrios T., Brodin Nina, Bruce Ian N., González-Gay Miguel Ángel, Jacobsen Sren, Kerekes György, Marchiori Francesca, Mukhtyar Chetan, Ramos-Casals Manuel, Sattar Naveed, Schreiber Karen, Sciascia Savino, Svenungsson Elisabet, Szekanecz Zoltan, Tausche Anne-Kathrin, Tyndall Alan, van Halm Vokko, Voskuyl Alexandre, Macfarlane Gary J., Ward Michael M., Nurmohamed Michael T., Tektonidou Maria G.
Dátum:2022
ISSN:0003-4967
Megjegyzések:Objective To develop recommendations for cardiovascular risk (CVR) management in gout, vasculitis, systemic sclerosis (SSc), myositis, mixed connective tissue disease (MCTD), Sjögren's syndrome (SS), systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). Methods Following European League against Rheumatism (EULAR) standardised procedures, a multidisciplinary task force formulated recommendations for CVR prediction and management based on systematic literature reviews and expert opinion. Results Four overarching principles emphasising the need of regular screening and management of modifiable CVR factors and patient education were endorsed. Nineteen recommendations (eleven for gout, vasculitis, SSc, MCTD, myositis, SS; eight for SLE, APS) were developed covering three topics: (1) CVR prediction tools; (2) interventions on traditional CVR factors and (3) interventions on disease-related CVR factors. Several statements relied on expert opinion because high-quality evidence was lacking. Use of generic CVR prediction tools is recommended due to lack of validated rheumatic diseases-specific tools. Diuretics should be avoided in gout and beta-blockers in SSc, and a blood pressure target <130/80 mm Hg should be considered in SLE. Lipid management should follow general population guidelines, and antiplatelet use in SLE, APS and large-vessel vasculitis should follow prior EULAR recommendations. A serum uric acid level <0.36 mmol/L (<6 mg/dL) in gout, and disease activity control and glucocorticoid dose minimisation in SLE and vasculitis, are recommended. Hydroxychloroquine is recommended in SLE because it may also reduce CVR, while no particular immunosuppressive treatment in SLE or uratelowering therapy in gout has been associated with CVR lowering. Conclusion These recommendations can guide clinical practice and future research for improving CVR management in rheumatic and musculoskeletal diseases
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Annals Of The Rheumatic Diseases. - 81 : 6 (2022), p. 768-779. -
További szerzők:Vedder, Daisy Houben, Eline Boekel, Laura Atzeni, Fabiola Badreh, Sara Boumpas, Dimitrios Brodin, Nina Bruce, Ian N. Gonzalez-Gay, Miguel A. Jacobsen, Sren Kerekes György (1973-) (belgyógyász, kardiológus, angiológus) Marchiori, Francesca Mukhtyar, Chetan Ramos-Casals, Manuel Sattar, Naveed Schreiber, Karen Sciascia, Savino Svenungsson, Elisabet Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Tausche, Anne-Kathrin Tyndall, Alan van Halm, Vokko Voskuyl, Alexandre Macfarlane, Gary J. Ward, Michael M. Nurmohamed, Michael T. Tektonidou, Maria G.
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001-es BibID:BIBFORM054431
Első szerző:Kerekes György (belgyógyász, kardiológus, angiológus)
Cím:Rheumatoid arthritis and metabolic syndrome / György Kerekes, Michael T. Nurmohamed, Miguel A. González-Gay, Ildikó Seres, György Paragh, Zsófia Kardos, Zsuzsa Baráth, László Tamási, Pál Soltész, Zoltán Szekanecz
Dátum:2014
ISSN:1759-4790 1759-4804
Megjegyzések:Rheumatoid arthritis (RA), especially active disease, is associated with considerable changes in body composition, lipids, adipokines and insulin sensitivity. Metabolic changes, such as increased total cholesterol, LDL cholesterol and triglyceride levels, occur even in preclinical RA. Active RA is associated with decreased lipid levels, BMI, fat and muscle mass, as well as altered lipid profiles. Some of these changes are also seen in metabolic syndrome, and could increase cardiovascular mortality. Importantly, the systemic inflammation underlying RA is an independent risk factor for cardiovascular disease. This Perspectives article summarizes data on the associations of various components of metabolic syndrome with RA, and discusses the effects of biologic therapy on these factors. The authors propose that components of metabolic syndrome should be monitored in patients with RA throughout the disease course, and argue that optimal disease control using biologic agents might attenuate several adverse effects of metabolic syndrome in these patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
undifferentiated connetice tissue disease
entholtelial cell markers
endothelial dísfunction
flow-mediated vasodilation
accelered atherosclerosis
Megjelenés:Nature Reviews Rheumatology 10 : 11 (2014), p. 691-696. -
További szerzők:Nurmohamed, Michael T. Gonzalez-Gay, Miguel A. Seres Ildikó Paragh György (1953-) (belgyógyász) Kardos Zsófia Baráth Zsuzsa Tamási László Soltész Pál (1961-) (belgyógyász, kardiológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Pályázati támogatás:TÁMOP-4.2.2.A-11/1/KONV-2012-0031
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TÁMOP-4.2.2.A-11/1/KONV-2012-0031
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001-es BibID:BIBFORM033405
Első szerző:Kerekes György (belgyógyász, kardiológus, angiológus)
Cím:Validated methods for assessment of subclinical atherosclerosis in rheumatology / György Kerekes, Pál Soltész, Michael T. Nurmohamed, Miguel A. Gonzalez-Gay, Maurizio Turiel, Edit Végh, Yehuda Shoenfeld, Iain McInnes, Zoltán Szekanecz
Dátum:2012
ISSN:1759-4790
Megjegyzések:Rheumatoid arthritis, as well as other types of arthritides and connective tissue diseases, is associated with accelerated atherosclerosis, and increased cardiovascular morbidity and mortality. The early signs of cardiovascular disease therefore need to be recognized in patients with these conditions so that effective cardiovascular protection can be introduced. This Review provides an overview of validated techniques that are currently available to determine subclinical atherosclerosis in patients with rheumatic conditions. Techniques for early assessment of endothelial dysfunction include brachial artery flow-mediated vasodilation and laser Doppler flowmetry. Coronary circulation can be assessed by measuring coronary flow reserve using CT, MRI or PET based techniques. The standard indicators of arterial stiffness are pulse-wave velocity and the augmentation index. Carotid atherosclerosis is determined by the common carotid intima- media thickness (ccIMT) measurement or by the assessment of plaques and plaque areas. The combination of ccIMT with plaque assessment is likely to increase the predictive value of this approach. The potential use of a multimarker approach to increase the diagnostic and prognostic value of these clinical assessments is also discussed.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Nature Reviews Rheumatology 8 : 4 (2012), p. 224-234. -
További szerzők:Soltész Pál (1961-) (belgyógyász, kardiológus) Nurmohamed, Michael T. Gonzalez-Gay, Miguel A. Turiel, Maurizio Végh Edit (1978-) (reumatológus, belgyógyász) Shoenfeld, Yehuda McInnes, Iain Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Pályázati támogatás:TÁMOP-4.2.2.A-11/1/KONV-2012-0031
TÁMOP
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4.

001-es BibID:BIBFORM044442
Első szerző:Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:Miscellaneous Inflammatory Arthritides 1 / Zoltán Szekanecz, György Kerekes, Michael Nurmohamed
Dátum:2012
Tárgyszavak:Orvostudományok Klinikai orvostudományok könyvfejezet
Megjelenés:Textbook on rheumatic diseases / eds. Johannes W. J. Bijlsma, Jose Antonia. - p. 390-420.
További szerzők:Kerekes György (1973-) (belgyógyász, kardiológus, angiológus) Nurmohamed, Michael T.
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