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1.

001-es BibID:BIBFORM044304
Első szerző:Karell, Kati
Cím:Genetic dissection between coeliac disease and dermatitis herpetiformis in sib pairs / Karell K., Korponay-Szabo I., Szalai Z., Holopainen P., Mustalahti K., Collin P., Mäki M., Partanen J.
Dátum:2002
ISSN:0003-4800
Megjegyzések:Gluten sensitive enteropathy has various manifestations, of which the two major forms are classical coeliac disease (cCD) and dermatitis herpetiformis (DH). In cCD predominantly the small intestine is affected, whereas in DH also the skin is affected showing typical rash and IgA deposits. The symptoms in both forms are dependent on gluten intake. The factors diversifying these two clinical outcomes are unknown. In the present report we evaluated the role of the major genetic susceptibility locus, HLA DQ, in 25 families, in which both forms of the disease, cCD and DH, occurred in siblings. By using the family-based approach it can be assumed that within each family variation in environmental factors is substantially lower than in the standard case-control setting, and also the problems related to population stratification can be avoided. Results from the Finnish family material with 25 discordant and 85 concordant sib pairs, and from additional case-control material comprising 71 unrelated Hungarian DH and 68 cCD patients, together indicated that the HLA DQ locus did not differ between the two major outcomes of gluten sensitive enteropathy. The non-HLA DR;DQ factors are critical for the different clinical manifestations of gluten sensitivity.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Annals Of Human Genetics 66 : 5-6 (2002), p. 387-392. -
További szerzők:Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Szalai Zsuzsanna Holopainen, P. Mustalahti, Kirsi Collin, P. Mäki, Markku Partanen, Jukka
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2.

001-es BibID:BIBFORM023665
Első szerző:Raivio, Tiina
Cím:Self transglutaminase-based rapid coeliac disease antibody detection by a lateral flow method / T. Raivio, K. Kaukinen, E. Nemes, K. Laurila, P. Collin, J. B. Kovács, M. Mäki, I. R. Korponay-Szabó
Dátum:2006
Megjegyzések:The conventional coeliac disease antibody tests require patient's sera, and are laborious and time-consuming. AIM: To evaluate a newly developed rapid whole blood test in coeliac disease antibody detection, and its suitability for office use. METHODS: Endogenous tissue transglutaminase found in red blood cells in a whole blood fingertip or venous sample is liberated upon haemolysis and complexes with tissue transglutaminase antibodies, if present. The complexes, captured by a lateral flow system, are visualized within 5 min. Stored samples from 121 untreated, 106 treated coeliac disease patients and 107 controls were evaluated and compared with serum endomysium and tissue transglutaminase antibody tests and histology; 150 patients were prospectively tested on site in the doctor's office. RESULTS: The rapid test showed sensitivity (96.7%) comparable with the serum endomysium and tissue transglutaminase antibody tests from stored samples; specificity was slightly lower (93.5%). When tested on site the results were concordant in 96.7% of cases compared with endomysium and tissue transglutaminase antibody results. The test recognized the disappearance of tissue transglutaminase antibodies on a gluten-free diet. CONCLUSIONS: The self tissue transglutaminase-based rapid test can be easily carried out from a fingertip blood sample on site in the physician's office for both coeliac disease case finding and dietary monitoring purposes.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Alimentary Pharmacology & Therapeutics. - 24 : 1 (2006), p. 147-154. -
További szerzők:Kaukinen, Katri Nemes Éva (1957-) (csecsemő- és gyermekgyógyász, gasztroenterológus) Laurila, Kaija Collin, P. B. Kovács Judit Mäki, Markku Korponay-Szabó Ilma (1959-) (gyermekgyógyász)
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3.

001-es BibID:BIBFORM002287
Első szerző:Raivio, Tiina
Cím:Performance of a new rapid whole blood coeliac test in adult patients with low prevalence of endomysial antibodies / Raivio T., Korponay-Szabó I., Collin P., Laurila K., Huhtala H., Kaartinen T., Partanen J., Mäki M., Kaukinen K.
Dátum:2007
Megjegyzések:In coeliac disease endomysial and transglutaminase autoantibodies are directed against the human autoantigen, transglutaminase. The conventional coeliac antibody tests are performed from serum samples in centralized laboratories. Aims. To evaluate a rapid and easy immunoglobulin A-class whole blood point-of-care test and its commercial application, the Biocard test, in coeliac autoantibody detection. Methods. In the whole blood point-of-care test transglutaminase is liberated from the red blood cells by haemolysis. Transglutaminase antibodies, if present, complex with the liberated antigen, and are visualized. Altogether 51 biopsy-proven untreated coeliac adult patients, 48 of the same patients after treatment, and 36 controls were tested. The point-of-care test results were compared with serum endomysial and transglutaminase antibody and Biocard test results and histology. Results. The whole blood point-of-care test was as sensitive (82%) as the serum endomysium test (80%) in detecting untreated coeliac disease while the serum transglutaminase antibody test was superior (88%). The tests had 100% specificity. A positive point-of-care test result seroconverted or the test reaction weakened in 90% of the treated coeliac patients. Biocard test-positive were 22 of the 24 tested untreated coeliac patients. Biocard test-negative were 15 of 19 controls. Conclusions. The whole blood rapid tests are as reliable as the conventional serological tests in detecting untreated coeliac disease and in coeliac disease diet monitoring.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Coeliac disease
Point-of-care test
Tissue transglutaminase
Whole blood
Megjelenés:Digestive and Liver Disease 39 : 12 (2007), p. 1057-1063. -
További szerzők:Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Collin, P. Laurila, Kaija Huhtala, Heini Kaartinen, Tanja Partanen, Jukka Mäki, Markku Kaukinen, Katri
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4.

001-es BibID:BIBFORM044282
Első szerző:Salmi, T. T.
Cím:Immunoglobulin A autoantibodies against transglutaminase 2 in the small intestinal mucosa predict forthcoming coeliac disease / Salmi T. T., Collin P., Järvinen O., Haimila K., Partanen J., Laurila K., Korponay-Szabo I. R., Huhtala H., Reunala T., Mäki M., Kaukinen K.
Dátum:2006
ISSN:0269-2813
Megjegyzések:BACKGROUND: Reliable markers of early developing coeliac diseases are needed. Coeliac autoantibodies in the serum or Marsh I inflammation may be indicators of subsequent coeliac disease.AIM:To investigate whether determination of intestinal transglutaminase 2-targeted autoantibody deposits would detect early developing coeliac disease better than previous methods.METHODS:The study investigated patients previously excluded for coeliac disease: 25 had positive serum coeliac autoantibodies (endomysial), 25 antibody-negative had Marsh I, and 25 antibody-negative had Marsh 0 finding. Seven (median) years after baseline investigation, new coeliac cases were recorded, and small bowel biopsy was offered to the rest of the patients. Serum and intestinal coeliac autoantibodies and intraepithelial lymphocytes were assessed as indicators of developing coeliac disease.RESULTS:Seventeen patients had developed coeliac disease: 13 in the autoantibody-positive group, three in the Marsh I group and one in the Marsh 0 group. At baseline, intestinal coeliac autoantibody deposits had a sensitivity and specificity of 93% and 93% in detecting subsequent coeliac disease, CD3+ 59% and 57%, gammadelta+ 76% and 60%, and villous tip intraepithelial lymphocytes 88% and 71%, respectively.CONCLUSIONS:Endomysial antibodies with normal histology indicates early developing coeliac disease. Transglutaminase 2-targeted intestinal autoantibody deposits proved the best predictor of subsequent coeliac disease
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Alimentary Pharmacology & Therapeutics. - 24 : 3 (2006), p. 541-552. -
További szerzők:Collin, P. Jarvinen, O. Haimila, Katri Partanen, Jukka Laurila, Kaija Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Huhtala, Heini Reunala, T. Mäki, Markku Kaukinen, Katri
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5.

001-es BibID:BIBFORM019942
Első szerző:Salmi, T. T.
Cím:Endomysial antibody-negative coeliac disease : clinical characteristics and intestinal autoantibody deposits / T. T. Salmi, P. Collin, I. R. Korponay-Szabó, K. Laurila, J. Partanen, H. Huhtala, R. Király, L. Lorand, T. Reunala, M. Mäki, K. Kaukinen
Dátum:2006
ISSN:0017-5749
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Gut. - 55 : 12 (2006), p. 1746-1753. -
További szerzők:Collin, P. Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Laurila, Kaija Partanen, Jukka Huhtala, Heini Király Róbert (1975-) (biológus) Lorand, L. Reunala, T. Mäki, Markku Kaukinen, Katri
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