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001-es BibID:	BIBFORM006244
Első szerző:	Haimila, Katri
Cím:	The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and common variable immunodeficiency / K. Haimila, E. Einarsdottir, A. de Kauwe, L. L. Koskinen, Q. Pan-Hammarström, T. Kaartinen, K. Kurppa, F. Ziberna, T. Not, S. Vatta, A. Ventura, I. R. Korponay-Szabó, R. Ádány, Z. Pocsai, G. Széles, E. Dukes, K. Kaukinen, M. Mäki, S. Koskinen, J. Partanen, L. Hammarström, P. Saavalainen
Dátum:	2009
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban IgAD genetic linkage association celia disease
Megjelenés:	Genes and Immunity 10 : 2 (2009), p. 151-161. -
További szerzők:	Einarsdottir, Elisabet de Kauwe, A. Koskinen, Lotta L. E. Pan-Hammarström, Qiang Kaartinen, Tanja Kurppa, Kalle Ziberna, Fabiana Not, Tarcisio Vatta, Serena Ventura, Alessandro Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Pocsai Zsuzsanna (1970-) (népegészségügyi szakember) Széles György (1969-) (epidemiológus) Dukes, Emma Kaukinen, Katri Mäki, Markku Koskinen, Seppo Partanen, Jukka Hammarström, Lennart Saavalainen, Päivi
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001-es BibID:	BIBFORM044301
Első szerző:	Kaukinen, Katri
Cím:	Small-bowel mucosal transglutaminase 2-specific IgA deposits in coeliac disease without villous atrophy : a prospective and randomized clinical study / Kaukinen Katri, Peräaho Markku, Collin Pekka, Partanen Jukka, Woolley Nina, Kaartinen Tanja, Nuutinen Tuula, Halttunen Tuula, Mäki Markku, Korponay-Szabo Ilma
Dátum:	2005
ISSN:	0036-5521
Megjegyzések:	OBJECTIVE:In coeliac disease, autoantibodies directed against transglutaminase 2 are produced in small-bowel mucosa, and they have been found to be deposited extracellularly. The aim of this study was to investigate whether such mucosal IgA deposits are important in the diagnostic work-up of early-stage coeliac disease without small-bowel mucosal villous atrophy.MATERIAL AND METHODS:Forty-one adults suspected of coeliac disease owing to increased density of mucosal gamma(delta)+ intraepithelial lymphocytes but normal villous morphology were randomized to gluten challenge or a gluten-free diet for 6 months. Clinically and histologically verified gluten dependency was compared with existence of small-bowel mucosal transglutaminase 2-specific extracellular IgA deposits and (coeliac disease-type) HLA DQ2 and DQ8; 34 non-coeliac subjects and 18 patients with classical coeliac disease served as controls.RESULTS:Of the 41 patients, 5 in the challenge group and 6 in the gluten-free diet group were clinically gluten sensitive; all 11 had HLA DQ2 or DQ8. Ten of these 11 patients showed transglutaminase 2-targeted mucosal IgA deposits, which were dependent on gluten consumption. Minimal IgA deposits were seen in only 3 out of 30 patients with suspected coeliac disease without any clinically detected gluten dependency. The deposits were found in all classical coeliac patients and in none of the non-coeliac control subjects.CONCLUSIONS:Clinically pertinent coeliac disease exists despite normal small-bowel mucosal villous architecture. Mucosal transglutaminase 2-specific IgA deposits can be utilized in detecting such patients with genetic gluten intolerance
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Scandinavian Journal Of Gastroenterology. - 40 : 5 (2005), p. 564-572. -
További szerzők:	Peräaho, Markku Collin, Pekka Partanen, Jukka Woolley, Nina Kaartinen, Tanja Nuutinen, Tuula Halttunen, Tuula Mäki, Markku Korponay-Szabó Ilma (1959-) (gyermekgyógyász)
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001-es BibID:	BIBFORM002287
Első szerző:	Raivio, Tiina
Cím:	Performance of a new rapid whole blood coeliac test in adult patients with low prevalence of endomysial antibodies / Raivio T., Korponay-Szabó I., Collin P., Laurila K., Huhtala H., Kaartinen T., Partanen J., Mäki M., Kaukinen K.
Dátum:	2007
Megjegyzések:	In coeliac disease endomysial and transglutaminase autoantibodies are directed against the human autoantigen, transglutaminase. The conventional coeliac antibody tests are performed from serum samples in centralized laboratories. Aims. To evaluate a rapid and easy immunoglobulin A-class whole blood point-of-care test and its commercial application, the Biocard test, in coeliac autoantibody detection. Methods. In the whole blood point-of-care test transglutaminase is liberated from the red blood cells by haemolysis. Transglutaminase antibodies, if present, complex with the liberated antigen, and are visualized. Altogether 51 biopsy-proven untreated coeliac adult patients, 48 of the same patients after treatment, and 36 controls were tested. The point-of-care test results were compared with serum endomysial and transglutaminase antibody and Biocard test results and histology. Results. The whole blood point-of-care test was as sensitive (82%) as the serum endomysium test (80%) in detecting untreated coeliac disease while the serum transglutaminase antibody test was superior (88%). The tests had 100% specificity. A positive point-of-care test result seroconverted or the test reaction weakened in 90% of the treated coeliac patients. Biocard test-positive were 22 of the 24 tested untreated coeliac patients. Biocard test-negative were 15 of 19 controls. Conclusions. The whole blood rapid tests are as reliable as the conventional serological tests in detecting untreated coeliac disease and in coeliac disease diet monitoring.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Coeliac disease Point-of-care test Tissue transglutaminase Whole blood
Megjelenés:	Digestive and Liver Disease 39 : 12 (2007), p. 1057-1063. -
További szerzők:	Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Collin, P. Laurila, Kaija Huhtala, Heini Kaartinen, Tanja Partanen, Jukka Mäki, Markku Kaukinen, Katri
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