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001-es BibID:	BIBFORM002288
Első szerző:	Szebeni Beáta
Cím:	Increased mucosal expression of toll-like receptor (TLR)2 and TLR4 in coeliac disease / Szebeni Beáta, Veres Gábor, Dezsőfi Antal, Rusai Krisztina, Vannai Ádám, Bokodi Géza, Vásárhelyi Barna, Korponay-Szabó Ilma, Tulassay Tivadar, Arató András
Dátum:	2007
Megjegyzések:	The dysregulation of adaptive immunity is extensively investigated in celiac disease (CD). Recent data also suggest, however, the implication of innate immunity in CD. Toll-like receptors (TLRs) play a central role in the initiation or maintenance of innate immune responses. The aim of this study was to characterise the expression of TLR2, TLR3, and TLR4 in duodenal biopsy samples taken from children with CD and from controls. Patients and Methods: Duodenal biopsy specimens were collected from 16 children with untreated CD, 9 children with treated CD, and 10 controls. The mRNA expression of TLR2, TLR3, and TLR4 was determined by semiquantitative reverse transcription-polymerase chain reaction. Protein levels of TLRs were determined by Western blot. Results: We found higher TLR2 and TLR4 mRNA expression and protein levels in the duodenalmucosa of children with treated CD and untreated CD compared with controls. TLR2 and TLR4 mRNA expression and protein levels were even higher in the duodenal mucosa of children with treated CD than in untreated CD. TLR3 mRNA expression was increased in the duodenal mucosa of children with treatedCD compared with untreated CD and controls. We were able to detect TLR3 protein only in the biopsy specimens of treated patients with CD. Conclusions: The alteration of TLR2 and TLR4 expression in the duodenal mucosa of patients with CD supports the potential implication of innate immune system in the pathomechanism of this disease.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Children-Coeliac disease Toll-like receptor 2 Toll-like receptor 3 Toll-like receptor 4
Megjelenés:	Journal of Pediatric Gastroenterology and Nutrition 45 : 2 (2007), p. 187-193. -
További szerzők:	Veres Gábor (1969-2020) (csecsemő- és gyermekgyógyász, gasztroenterológus) Dezsőfi Antal Rusai Krisztina Vannai Ádám Bokodi Géza Vásárhelyi Barna Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Tulassay Tivadar Arató András
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001-es BibID:	BIBFORM044278
Első szerző:	Sziksz Erna
Cím:	Increased Heat Shock Protein 72 Expression in Celiac Disease / Sziksz Erna, Veres Gábor, Vannay Ádám, Prókai Ágnes, Gál Krisztina, Ónody Anna, Korponay-Szabó Ilma Rita, Reusz György, Szabó András, Tulassay Tivadar, Arató András, Szebeni Beáta
Dátum:	2010
ISSN:	0277-2116
Megjegyzések:	BACKGROUND AND OBJECTIVES:Heat shock protein (HSP) 72, a known chaperone, has potential epithelial barrier protecting, antiapoptotic, and immune system regulatory effects; therefore, our aim was to study its involvement in the pathology of celiac disease (CD).PATIENTS AND METHODS:Duodenal biopsy specimens were collected from children with untreated and treated CD and from controls. mRNA expression, protein level, and localization of HSP72 were determined.RESULTS:Elevated HSP72 mRNA expression and higher protein levels were found in the duodenal mucosa of children with untreated CD as well as in children with treated CD compared with those in controls. In the duodenal mucosa of children with treated CD, HSP72 mRNA expression was decreased and HSP72 protein levels were lower than those in children with untreated CD. We detected intensive HSP72 staining in the villous enterocytes and immune cells of the lamina propria in the duodenal villi of children with untreated CD compared with that in controls.CONCLUSIONS:The increased expression and altered localization of HSP72 in CD indicate that HSP72 should have a role in protection against gliadin-induced cytotoxicity. HSP72 may exert antiapoptotic effect and contribute to preservation of intestinal epithelial barrier integrity. Moreover, HSP72 as a ligand of TLR2 and TLR4 may promote innate immune responses and warn the cells of the potential injury
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal Of Pediatric Gastroenterology And Nutrition. - 51 : 5 (2010), p. 573-578. -
További szerzők:	Veres Gábor (1969-2020) (csecsemő- és gyermekgyógyász, gasztroenterológus) Vannay Ádám Prokai Ágnes Gál Krisztina Ónody Anna Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Reusz György Szabó András (gyermekgyógyász) Tulassay Tivadar Arató András Szebeni Beáta
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001-es BibID:	BIBFORM044277
Első szerző:	Vannay Ádám
Cím:	Increased expression of hypoxia-inducible factor 1alpha in coeliac disease / Vannay Ádám, Sziksz Erna, Prókai Ágnes, Veres Gábor, Molnár Kriszta, Nagy Szakál Dorottya, Ónódy Anna, Korponay-Szabó Ilma R., Szabó András, Tulassay Tivadar, Arató András, Szebeni Beáta
Dátum:	2010
ISSN:	0031-3998
Megjegyzések:	Previously, it has been suggested that hypoxia-inducible factor (HIF) 1 signaling may play determinative role in the maintenance of the barrier function of the intestinal epithelium in inflammatory bowel disease. Our aim was to depict the alteration of HIF-1alpha and related genes in celiac disease (CD) where the importance of the barrier function is well known. Duodenal biopsy specimens were collected from 16 children with untreated CD, 9 children with treated CD and 10 controls. HIF-1alpha, trefoil factor 1 (TFF1), ecto-5-prime nucleotidase (CD73), and multi drug resistance gene 1 (MDR1) mRNA and HIF-1alpha protein expression were determined by real-time PCR and Western blot, respectively. Localization of HIF-1alpha was determined by immunofluorescent staining. We found increased HIF-1alpha and TFF1 mRNA and HIF-1alpha protein expression in the duodenal mucosa of children with untreated CD compared with controls or children with treated CD (p < 0.05). In untreated CD children, HIF-1alpha staining was present in cytoplasmic and nuclear region of the villous enterocytes. In treated CD mRNA expression of CD73 and MDR1 were increased compared with controls (p < 0.01 and 0.05, respectively). Our results of increased mucosal HIF-1alpha expression in CD children suggest the contribution of this signaling pathway in the pathomechanism of CD.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Pediatric Research. - 68 : 2 (2010), p. 118-122. -
További szerzők:	Sziksz Erna Prokai Ágnes Veres Gábor (1969-2020) (csecsemő- és gyermekgyógyász, gasztroenterológus) Molnár Kriszta Nagy Szakál Dorottya Ónody Anna Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Szabó András (gyermekgyógyász) Tulassay Tivadar Arató András Szebeni Beáta
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