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1.

001-es BibID:BIBFORM006244
Első szerző:Haimila, Katri
Cím:The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and common variable immunodeficiency / K. Haimila, E. Einarsdottir, A. de Kauwe, L. L. Koskinen, Q. Pan-Hammarström, T. Kaartinen, K. Kurppa, F. Ziberna, T. Not, S. Vatta, A. Ventura, I. R. Korponay-Szabó, R. Ádány, Z. Pocsai, G. Széles, E. Dukes, K. Kaukinen, M. Mäki, S. Koskinen, J. Partanen, L. Hammarström, P. Saavalainen
Dátum:2009
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
IgAD
genetic linkage
association
celia disease
Megjelenés:Genes and Immunity 10 : 2 (2009), p. 151-161. -
További szerzők:Einarsdottir, Elisabet de Kauwe, A. Koskinen, Lotta L. E. Pan-Hammarström, Qiang Kaartinen, Tanja Kurppa, Kalle Ziberna, Fabiana Not, Tarcisio Vatta, Serena Ventura, Alessandro Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Pocsai Zsuzsanna (1970-) (népegészségügyi szakember) Széles György (1969-) (epidemiológus) Dukes, Emma Kaukinen, Katri Mäki, Markku Koskinen, Seppo Partanen, Jukka Hammarström, Lennart Saavalainen, Päivi
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2.

001-es BibID:BIBFORM009656
Első szerző:Koskinen, Lotta L. E.
Cím:Cost-effective HLA typing with tagging SNPs predicts celiac disease risk haplotypes in the Finnish, Hungarian, and Italian populations / Lotta Koskinen, Jihane Romanos, Katri Kaukinen, Kirsi Mustalahti, Korponay-Szabo Ilma, Donatella Barisani, Maria Teresa Bardella, Fabiana Ziberna, Serena Vatta, Széles György, Pocsai Zsuzsa, Kati Karell, Katri Haimila, Ádány Róza, Tarcisio Not, Alessandro Ventura, Markku Mäki, Jukka Partanen, Cisca Wijmenga, Päivi Saavalainen
Dátum:2009
ISSN:0093-7711 (Print)
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
HLA
Human leukocyte antigen
Celiac disease
Tagging SNP
Megjelenés:Immunogenetics. - 61 : 4 (2009), p. 247-256. -
További szerzők:Romanos, Jihane Kaukinen, Katri Mustalahti, Kirsi Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Barisani, Donatella Bardella, Maria Teresa Ziberna, Fabiana Vatta, Serena Széles György (1969-) (epidemiológus) Pocsai Zsuzsanna (1970-) (népegészségügyi szakember) Karell, Kati Haimila, Katri Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Not, Tarcisio Ventura, Alessandro Mäki, Markku Partanen, Jukka Wijmenga, Cisca Saavalainen, Päivi
Internet cím:DOI
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3.

001-es BibID:BIBFORM044281
Első szerző:Koskinen, Outi
Cím:Gluten-dependent small bowel mucosal transglutaminase 2-specific IgA deposits in overt and mild enteropathy coeliac disease / Koskinen Outi, Collin Pekka, Korponay-Szabo Ilma, Salmi Teea, Iltanen Sari, Haimila Katri, Partanen Jukka, Mäki Markku, Kaukinen Katri
Dátum:2008
ISSN:0277-2116
Megjegyzések:OBJECTIVES: In coeliac disease, immunoglobulin (Ig)A-class autoantibodies against transglutaminase-2 are produced in the small intestinal mucosa, where they are deposited extracellularly. It remains unclear whether positive intestinal transglutaminase-2-targeted IgA deposits in subjects having normal small bowel mucosal morphology are signs of early-stage coeliac disease. We evaluated the gluten dependency of these deposits in overt and mild enteropathy coeliac disease.PATIENTS AND METHODS:All together 48 subjects suspected of coeliac disease but having normal small bowel mucosal villi were enrolled; 28 of them had latent coeliac disease. The remaining 20 having positive intestinal IgA deposits adopted a gluten-free diet before villous atrophy had developed. For comparison, 13 patients with overt coeliac disease and 42 noncoeliac controls were studied. Small bowel mucosal transglutaminase-2-specific autoantibodies were compared with villous morphology, intraepithelial lymphocyte densities, and serum coeliac autoantibodies.RESULTS:Intestinal IgA deposits were seen in all but 1 of the patients with latent coeliac disease, when the morphology was still intact; the intensity of these deposits increased as villous atrophy developed and decreased again on a gluten-free diet. In 20 patients with intestinal IgA deposits in normal villi, the intensity of the deposits decreased with the diet similarly to that seen in patients with overt coeliac disease. Mucosal IgA deposits were seen initially only in 5% of noncoeliac controls and in 8% after extended gluten consumption.CONCLUSIONS:The response of small bowel mucosal transglutaminase-2-specific IgA deposits for dietary intervention was similar in overt and mild enteropathy coeliac disease. Detection of such IgA deposits thus offers a good diagnostic tool to uncover early-stage coeliac disease.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Pediatric Gastroenterology And Nutrition. - 47 : 4 (2008), p. 436-442. -
További szerzők:Collin, Pekka Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Salmi, T. T. Iltanen, Sari Haimila, Katri Partanen, Jukka Mäki, Markku Kaukinen, Katri
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DOI
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4.

001-es BibID:BIBFORM044282
Első szerző:Salmi, T. T.
Cím:Immunoglobulin A autoantibodies against transglutaminase 2 in the small intestinal mucosa predict forthcoming coeliac disease / Salmi T. T., Collin P., Järvinen O., Haimila K., Partanen J., Laurila K., Korponay-Szabo I. R., Huhtala H., Reunala T., Mäki M., Kaukinen K.
Dátum:2006
ISSN:0269-2813
Megjegyzések:BACKGROUND: Reliable markers of early developing coeliac diseases are needed. Coeliac autoantibodies in the serum or Marsh I inflammation may be indicators of subsequent coeliac disease.AIM:To investigate whether determination of intestinal transglutaminase 2-targeted autoantibody deposits would detect early developing coeliac disease better than previous methods.METHODS:The study investigated patients previously excluded for coeliac disease: 25 had positive serum coeliac autoantibodies (endomysial), 25 antibody-negative had Marsh I, and 25 antibody-negative had Marsh 0 finding. Seven (median) years after baseline investigation, new coeliac cases were recorded, and small bowel biopsy was offered to the rest of the patients. Serum and intestinal coeliac autoantibodies and intraepithelial lymphocytes were assessed as indicators of developing coeliac disease.RESULTS:Seventeen patients had developed coeliac disease: 13 in the autoantibody-positive group, three in the Marsh I group and one in the Marsh 0 group. At baseline, intestinal coeliac autoantibody deposits had a sensitivity and specificity of 93% and 93% in detecting subsequent coeliac disease, CD3+ 59% and 57%, gammadelta+ 76% and 60%, and villous tip intraepithelial lymphocytes 88% and 71%, respectively.CONCLUSIONS:Endomysial antibodies with normal histology indicates early developing coeliac disease. Transglutaminase 2-targeted intestinal autoantibody deposits proved the best predictor of subsequent coeliac disease
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Alimentary Pharmacology & Therapeutics. - 24 : 3 (2006), p. 541-552. -
További szerzők:Collin, P. Jarvinen, O. Haimila, Katri Partanen, Jukka Laurila, Kaija Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Huhtala, Heini Reunala, T. Mäki, Markku Kaukinen, Katri
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DOI
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5.

001-es BibID:BIBFORM044280
Első szerző:Stenman, Satumarja M.
Cím:Secretion of celiac disease autoantibodies after in vitro gliadin challenge is dependent on small-bowel mucosal transglutaminase 2-specific IgA deposits / Stenman Satumarja M., Lindfors Katri, Korponay-Szabo Ilma R., Lohi Olli, Saavalainen Paivi, Partanen Jukka, Haimila Katri, Wieser Herbert, Maki Markku, Kaukinen Katri
Dátum:2008
ISSN:1471-2172
Megjegyzések:BACKGROUND:In celiac disease gluten, the disease-inducing toxic component in wheat, induces the secretion of autoantibodies which are targeted against transglutaminase 2 (TG2). These autoantibodies are produced in the small-intestinal mucosa, where they can be found deposited extracellularly below the epithelial basement membrane and around mucosal blood vessels. In addition, during gluten consumption these autoantibodies can also be detected in patients' serum but disappear from the circulation on a gluten-free diet. Interestingly, after adoption of a gluten-free diet the serum autoantibodies disappear from the circulation more rapidly than the small-intestinal mucosal autoantibody deposits. The toxicity of gluten and the secretion of the disease-specific autoantibodies have been widely studied in organ culture of small-intestinal biopsy samples, but results hitherto have been contradictory. Since the mucosal autoantibodies disappear slowly after a gluten-free diet, our aim was to establish whether autoantibody secretion to organ culture supernatants in treated celiac disease patient biopsies is related to the duration of the diet and further to the pre-existence of mucosal TG2-specific IgA deposits in the cultured biopsy samples.RESULTS:In the organ culture system conducted with biopsies derived from treated celiac disease patients, gliadin induced secretion of autoantibodies to culture supernatants, reduced epithelial cell height and increased the density of lamina proprial CD25+ cells. However, these changes could be demonstrated only in biopsies from short-term treated celiac disease patients, where the small-intestinal mucosal TG2-specific IgA autoantibody deposits were still present. Furthermore, in these biopsies autoantibody secretion could be stimulated fully only after a 48-hour gliadin challenge.CONCLUSION:Our results show that studies focusing on the toxic effects of gliadin in the organ culture system should be carried out with biopsy samples from short-term treated celiac disease patients who are likely still to have mucosal IgA deposits present. In addition to providing an explanation for the discrepancies in previous publications, the present study also enables further validation of the organ culture method.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Bmc Immunology. - 9 : 1 (2008), p. [6]. -
További szerzők:Lindfors, Katri Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Lohi, Olli Saavalainen, Päivi Partanen, Jukka Haimila, Katri Wieser, Herbert Mäki, Markku Kaukinen, Katri
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DOI
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