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1.

001-es BibID:BIBFORM011928
Első szerző:Caja, Sergio
Cím:Inhibition of transglutaminase 2 enzymatic activity ameliorates the anti-angiogenic effects of coeliac disease autoantibodies / Caja S., Myrsky E., Korponay-Szabo I., Nadalutti C., Sulic A. M., Lavric M., Sblattero D., Marzari R., Collighan R., Mongeot A., Griffin M., Maki M., Kaukinen K., Lindfors K.
Dátum:2010
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Scandinavian Journal of Gastroenterology. - 45 : 4 (2010), p. 421-427. -
További szerzők:Myrsky, Essi Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Nadalutti, Cristina Sulic, Ana-Marija Lavric, Miha Sblattero, Daniele Marzari, Roberto Collighan, Russell Mongeot, Alexandre Griffin, Martin Mäki, Markku Kaukinen, Katri Lindfors, Katri
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2.

001-es BibID:BIBFORM069472
Első szerző:Kalliokoski, Suvi
Cím:Transglutaminase 2-specific coeliac disease autoantibodies induce morphological changes and signs of inflammation in the small-bowel mucosa of mice / Suvi Kalliokoski, Victoria Ortín Piqueras, Rafael Frías, Ana-Marija Sulic, Juha A. E. Määttä, Niklas Kähkönen, Keijo Viiri, Heini Huhtala, Arja Pasternack, Kaija Laurila, Daniele Sblattero, Ilma R. Korponay-Szabó, Markku Mäki, Sergio Caja, Katri Kaukinen, Katri Lindfors
Dátum:2017
ISSN:0939-4451 1438-2199
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Amino Acids 49 : 3 (2017), p. 529-540. -
További szerzők:Piqueras, Victoria Ortín Frías, Rafael Sulic, Ana-Marija Määttä, Juha A. E. Kähkönen, Niklas Viiri, Keijo Huhtala, Heini Pasternack, Arja Laurila, Kaija Sblattero, Daniele Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Mäki, Markku Caja, Sergio Kaukinen, Katri Lindfors, Katri
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3.

001-es BibID:BIBFORM056541
Első szerző:Kalliokoski, Suvi
Cím:Injection of celiac disease patient sera or immunoglobulins to mice reproduces a condition mimicking early developing celiac disease / Suvi Kalliokoski, Sergio Caja, Rafael Frias, Kaija Laurila, Outi Koskinen, Onni Niemelä, Markku Mäki, Katri Kaukinen, Ilma R. Korponay-Szabó, Katri Lindfors
Dátum:2015
ISSN:0946-2716
Megjegyzések:Typical features of celiac disease are small-bowel villus atrophy, crypt hyperplasia, and inflammation which develop gradually concomitant with ingestion of gluten. In addition, patients have anti-transglutaminase 2 (TG2) autoantibodies in their serum and tissues. The aim of this study was to establish whether celiac disease can be passively transferred to mice by serum or immunoglobulins. Serum aliquots or purified immunoglobulins (Ig) were intraperitoneally injected into Hsd:Athymic Nude-Foxn1nu mice for 8 or 27 days. As mice do not have proper IgA transport from peritoneum to blood, sera with a high content of IgG class anti-TG2 antibodies from untreated IgA-deficient celiac patients were used. Mouse sera were tested for celiac disease-specific autoantibodies, and several tissues were analyzed for autoantibody deposits targeted to TG2. Morphological assessment was made of the murine small intestinal mucosa. Injection of celiac disease patient sera or total IgG led to a significant delay in weight gain and mild diarrhea in a subset of mice. The mice injected with celiac patient sera or IgG had significantly decreased villus height crypt depth (Vh/CrD) ratios and celiac diseasespecific autoantibody deposits targeted to TG2 in several tissues, including the small intestine. None of these features were observed in control mice. We conclude that administration of IgA-deficient celiac disease patient serum or total IgG induces both deterioration of the intestinal mucosa and clinical features of celiac disease in mice. The experimentally induced condition in the mice injected with patient serum or IgG resembles early developing celiac disease in humans.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Autoantibodies
Celiac disease
Passivetransfer
Transglutaminase 2
Megjelenés:Journal of Molecular Medicine-Jmm 93 : 1 (2015), p. 51-62. -
További szerzők:Caja, Sergio Frías, Rafael Laurila, Kaija Koskinen, Outi Niemelä, Onni Mäki, Markku Kaukinen, Katri Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Lindfors, Katri
Pályázati támogatás:101788
OTKA
TÁMOP-4.2.2.A-11/1/KONV-2012-0023
TÁMOP
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4.

001-es BibID:BIBFORM048568
035-os BibID:Article ID: e65887
Első szerző:Kalliokoski, Suvi
Cím:Celiac Disease-Specific TG2-Targeted Autoantibodies Inhibit Angiogenesis Ex Vivo and In Vivo in Mice by Interfering with Endothelial Cell Dynamics / Suvi Kalliokoski, Ana-Marija Sulic, Ilma R. Korponay-Szabo, Zsuzsa Szondy, Rafael Frias, Mileidys Alea Perez, Stefania Martucciello, Anne Roivainen, Lauri J. Pelliniemi, Carla Esposito, Martin Griffin, Daniele Sblattero, Markku Mäki, Katri Kaukinen, Katri Lindfors, Sergio Caja
Dátum:2013
ISSN:1932-6203
Megjegyzések:A characteristic feature of celiac disease is the presence of circulating autoantibodies targeted against transglutaminase 2 (TG2), reputed to have a function in angiogenesis. In this study we investigated whether TG2-specific autoantibodies derived from celiac patients inhibit angiogenesis in both ex vivo and in vivo models and sought to clarify the mechanism behind this phenomenon. We used the ex vivo murine aorta-ring and the in vivo mouse matrigel-plug assays to address aforementioned issues. We found angiogenesis to be impaired as a result of celiac disease antibody supplementation in both systems. Our results also showed the dynamics of endothelial cells was affected in the presence of celiac antibodies. In the in vivo angiogenesis assays, the vessels formed were able to transport blood despite impairment of functionality after treatment with celiac autoantibodies, as revealed by positron emission tomography. We conclude that celiac autoantibodies inhibit angiogenesis ex vivo and in vivo and impair vascular functionality. Our data suggest that the anti-angiogenic mechanism of the celiac disease-specific autoantibodies involves extracellular TG2 and inhibited endothelial cell mobility.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Plos One [electronic resource]. - 8 : 6 (2013), [8] p. -
További szerzők:Sulic, Ana-Marija Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Szondy Zsuzsanna (1959-) (molekuláris sejtbiológus, biokémikus) Frías, Rafael Perez, Mileidys Alea Martucciello, Stefania Roivainen, Anne Pelliniemi, Lauri J. Esposito, Carla Griffin, Martin Sblattero, Daniele Mäki, Markku Kaukinen, Katri Lindfors, Katri Caja, Sergio
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5.

001-es BibID:BIBFORM044274
Első szerző:Martucciello, Stefania
Cím:RhoB is associated with the anti-angiogenic effects of celiac patient transglutaminase 2-targeted autoantibodies / Martucciello Stefania, Lavric Miha, Toth Boglarka, Korponay-Szabo Ilma, Nadalutti Cristina, Myrsky Essi, Rauhavirta Tiina, Esposito Carla, Sulic Ana-Marija, Sblattero Daniele, Marzari Roberto, Mäki Markku, Kaukinen Katri, Lindfors Katri, Caja Sergio
Dátum:2012
ISSN:0946-2716
Megjegyzések:Celiac patient-derived anti-transglutaminase 2 (TG2) antibodies disturb several steps in angiogenesis, but the detailed molecular basis is not known. Therefore, we here analyzed by microarray technology the expression of a set of genes related to angiogenesis and endothelial cell biology in order to identify factors that could explain our previous data related to vascular biology in the context of celiac disease. To this end, in vitro models using human umbilical vein endothelial cells (HUVECs) or in vivo models of angiogenesis were used. A total of 116 genes were analyzed after treatment with celiac patient autoantibodies against TG2. Compared to treatment with control IgA celiac patient, total IgA induced a consistent expression change of 10 genes, the up-regulation of four and down-regulation of six. Of these genes the up-regulated RhoB was selected for further studies. RhoB expression was found to be up-regulated at both messenger RNA and protein level in response to celiac patient total IgA as well as anti-TG2-specific antibody derived from a celiac patient. Interestingly, down-regulation of RhoB by specific small interfering RNA treatment in endothelial cells could rescue the deranged endothelial length and tubule formation caused by celiac disease autoantibodies. RhoB function is controlled by its post-translational modification by farnesylation. This modification of RhoB required for its correct function can be prevented by the cholesterol lowering drug simvastatin, which was also able to abolish the anti-angiogenic effects of celiac anti-TG2 autoantibodies. Taken together, our results would suggest that RhoB plays a key role in the response of endothelial cells to celiac disease-specific anti-TG2 autoantibodies
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Molecular Medicine-Jmm. - 90 : 7 (2012), p. 817-826. -
További szerzők:Lavric, Miha Tóth Boglárka Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Nadalutti, Cristina Myrsky, Essi Rauhavirta, Tiina Esposito, Carla Sulic, Ana-Marija Sblattero, Daniele Marzari, Roberto Mäki, Markku Kaukinen, Katri Lindfors, Katri Caja, Sergio
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6.

001-es BibID:BIBFORM011940
Első szerző:Myrsky, Essi
Cím:Celiac disease IgA modulates vascular permeability in vitro through the activity of transglutaminase 2 and RhoA / Myrsky E., Caja S., Simon-Vecsei Z., Korponay-Szabo I., Nadalutti C., Collighan R., Mongeot A., Griffin M., Maki M., Kaukinen K., Lindfors K.
Dátum:2009
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Cellular and Molecular Life Sciences. - 66 : 20 (2009), p. 3375-3385. -
További szerzők:Caja, Sergio Simon-Vecsei Zsófia (1980-) (biológus) Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Nadalutti, Cristina Collighan, Russell Mongeot, Alexandre Griffin, Martin Mäki, Markku Kaukinen, Katri Lindfors, Katri
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7.

001-es BibID:BIBFORM025441
Első szerző:Simon-Vecsei Zsófia (biológus)
Cím:A single conformational transglutaminase 2 epitope contributed by three domains is critical for celiac antibody binding and effects / Zsófia Simon-Vecsei, Róbert Király, Péter Bagossi, Boglárka Tóth, Ingrid Dahlbom, Sergio Caja, Éva Csősz, Katri Lindfors, Daniele Sblattero, Éva Nemes, Markku Mäki, László Fésüs, Ilma R. Korponay-Szabó
Dátum:2012
Megjegyzések:The multifunctional, protein cross-linking transglutaminase 2 (TG2) is the main autoantigen in celiac disease, an autoimmune disorder with defined etiology. Glutamine-rich gliadin peptides from ingested cereals, after their deamidation by TG2, induce T-lymphocyte activation accompanied by autoantibody production against TG2 in 1-2% of the population. The pathogenic role and exact binding properties of these antibodies to TG2 are still unclear. Here we show that antibodies from different celiac patients target the same conformational TG2 epitope formed by spatially close amino acids of adjacent domains. Glu153 and 154 on the first alpha-helix of the core domain and Arg19 on first alpha-helix of the N-terminal domain determine the celiac epitope which is accessible both in the closed and open conformation of TG2 and dependent on the relative position of these helices. Met659 on the C-terminal domain also can cooperate in antibody binding. This composite epitope is disease-specific, recognized by antibodies derived from celiac tissues and associated with biological effects when passively transferred from celiac mothers into their newborns. These findings suggest that celiac antibodies are produced in a surface-specific way for which certain homology of the central glutamic acid residues of the TG2 epitope with deamidated gliadin peptides could be a structural basis. Monoclonal mouse antibodies with partially overlapping epitope specificity released celiac antibodies from patient tissues and antagonized their harmful effects in cell culture experiments. Such antibodies or similar specific competitors will be useful in further functional studies and in exploring whether interference with celiac antibody actions leads to therapeutic benefits.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
antibody epitope
transglutaminase
Molekuláris medicina
Megjelenés:Proceedings of the National Academy of Sciences of the United States of America. - 109 : 2 (2012), p. 431-436. -
További szerzők:Király Róbert (1975-) (biológus) Bagossi Péter (1966-2011) (biokémikus, vegyész) Tóth Boglárka Dahlbom, Ingrid Caja, Sergio Csősz Éva (1977-) (biokémikus, molekuláris biológus) Lindfors, Katri Sblattero, Daniele Nemes Éva (1957-) (csecsemő- és gyermekgyógyász, gasztroenterológus) Mäki, Markku Fésüs László (1947-) (orvos biokémikus) Korponay-Szabó Ilma (1959-) (gyermekgyógyász)
Pályázati támogatás:TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
Molekuláris mechanizmusok és sejtszintű eltérések coeliakiában
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