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001-es BibID:BIBFORM011939
Első szerző:Dahlbom, Ingrid
Cím:Prediction of clinical and mucosal severity of coeliac disease and dermatitis herpetiformis by quantification of IgA/IgG serum antibodies to tissue transglutaminase / Ingrid Dahlbom, Ilma R. Korponay-Szabó, Judit B. Kovács, Zsuzsanna Szalai, Markku Mäki, Tony Hansson
Dátum:2010
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Pediatric Gastroenterology and Nutrition. - 50 : 2 (2010), p. 140-146. -
További szerzők:Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Kovács Judit B. Szalai Zsuzsanna Mäki, Markku Hansson, Tony
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2.

001-es BibID:BIBFORM044310
Első szerző:Korponay-Szabó Ilma (gyermekgyógyász)
Cím:The human appendix : a composite substrate for anti-endomysium, anti-reticulin and anti-bowel antibody testing in coeliac disease / Ilma Rita Korponay-Szabó, Judit B. Kovács, Margit Lőrincz, Éva Török, Gyula Gorácz, Ferenc Csitáry
Dátum:1997
Megjegyzések:Primate tissues seem are important for the specificity of IgA type anti-endomysium (EmA),anti-reticulin (ARA) and anti-jejunum (JeA) antibody investigations in gluten-sensitive enteropathy(GSE). Substrate availability and costs for multiple testing are, however, frequent problems.METHODS: Sera of 300 non IgA-deficient GSE patients and 127 controls were tested on frozensections made from appendices surgically removed because of the suspicion of acuteappendicitis, but having normal histology. An indirect immunofluorescent method with IgA-stainingwas used. Conventional assays for EmA, ARA and JeA were carried out on monkey esophagus,human liver/kidney and jejunum respectively. Eighty sera were investigated also on humanumbilical cord tissue. RESULTS: A positive reaction on the appendix (App+) is composed of thestaining of the endomysium, reticulin network and tunica propria fibers, each corresponding to thestandard EmA, ARA and JeA pattern. 295/300 (98.3%) of the GSE patients and 0/127 of thecontrols were App+, without significant differences versus standard autoantibody reactions.Human umbilical cord positivity was observed in 50/54 GSE (92.6%) and in 2/26 (7.6%) controls(p<0.02 vs App+). Absorption studies resulted in fading of all components of App+, irrespective ofwhether esophagus, liver or jejunum had been used. CONCLUSIONS: Use of the human appendixtissue is a suitable and simple alternative to conventional EmA, JeA, ARA determinations. Allthree result in comparable specificity and sensitivity.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
celiac disease
Megjelenés:Medical Science Monitor. - 3 : 3 (1997), p. 295-289. -
További szerzők:Kovács Judit B. Lőrincz Margit Török Éva Gorácz Gyula Csitáry Ferenc
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3.

001-es BibID:BIBFORM044306
Első szerző:Korponay-Szabó Ilma (gyermekgyógyász)
Cím:High Prevalence of Silent Celiac Disease in Preschool Children Screened with IgA/IgG Antiendomysium Antibodies / Ilma R. Korponay-Szabó, Kovács B. Judit, Antal Czinner, Gyula Gorácz, Adrienn Vámos, Teréz Szabó
Dátum:1999
ISSN:0277-2116
Megjegyzések:BACKGROUND:Because of the different sensitivity and specificity of serologic tests, the search for silent celiac disease is usually performed with the combined or sequential use of several tests. Among these, the IgA-class endomysium antibody test has the highest specificity and positive predictive value, but it may overlook IgA-deficient patients.METHODS:To test a new one-step screening approach, serum samples from 427 apparently healthy, 3- to 6-year-old Hungarian children were investigated for IgA-class and IgG-class endomysium antibodies using monkey esophagus and human jejunum as substrates.RESULTS:Five new cases with flat mucosa were identified by strong endomysium antibody positivity and subsequent jejunal biopsy, yielding a celiac disease prevalence of 1:85. An additional child may have latent celiac disease (slight histologic changes at present). Two of the screening-detected celiac patients exhibited only IgG-class endomysium antibodies due to associated IgA-deficiency. Despite the young age of the screened population, antigliadin antibodies were positive in only three of the five celiac patients.CONCLUSIONS:Prevalence of celiac disease in the study population was much higher than expected on the basis of antigliadin antibody-based studies. The screening system used detected celiac cases in which there was IgA-deficiency and those in which there was not and also those negative for antigliadin antibodies. The findings suggest the importance of the primary testing of autoantibodies in future celiac disease screening policies
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Pediatric Gastroenterology And Nutrition. - 28 : 1 (1999), p. 26-30. -
További szerzők:Kovács Judit B. Czinner Antal Gorácz Gyula Vámos Adrienn Szabó Terézia
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