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1.

001-es BibID:BIBFORM096513
Első szerző:Auricchio, Renata
Cím:Growth rate of coeliac children is compromised before the onset of the disease / Auricchio Renata, Stellato Pio, Bruzzese Dario, Cielo Donatella, Chiurazzi Alfredo, Galatola Martina, Castillejo Gemma, Crespo Escobar Paula, Gyimesi Judith, Hartman Corina, Kolacek Sanja, Koletzko Sybille, Korponay-Szabo Ilma, Mearin Maria Luisa, Meijer Caroline, Piescik-Lech Malgoscia, Polanco Isabel, Ribes-Koninckx Carmen, Shamir Raanan, Szajewska Hania, Troncone Riccardo, Greco Luigi
Dátum:2020
ISSN:0003-9888
Megjegyzések:Introduction: Growth impairment has often been described in children who develop coeliac disease (CD). Based on data from the multicentre, longitudinal PreventCD study, we analysed the growth patterns of infants at genetic risk of CD, comparing those who developed CD by 6 years of age (CD 'cases', 113 infants) versus those who did not develop CD by 6 years (no CD 'controls', 831 infants). Methods: Weight and length/height were measured using a longitudinal protocol. Raw measurements were standardised, computing z-scores for length/height and weight; a linear mixed model was fitted to the data in order to compare the rate of growth in the two cohorts. Results: Neither cases nor controls had significant growth failure. However, when the mean z-scores for weight and height were analysed, there was a difference between the two groups starting at fourth month of life. When the growth pattern in the first year was analysed longitudinally using mixed models, it emerged that children who develop CD had a significantly lower growth rate in weight z-score (-0.028/month; 95% CI -0.038 to -0.017; p<0.001) and in length/height z-score (-0.018/month; 95% CI -0.031 to -0.005; p=0.008) than those who do not develop CD. When the whole follow-up period was analysed (0-6 years), differences between groups in both weight and length/height z-scores were confirmed. Conclusion: The growth of children at risk of CD rarely fell below 'clinical standards'. However, growth rate was significantly lower in cases than in controls. Our data suggest that peculiar pathways of growth are present in children who develop CD, long before any clinical or serological signs of the disease appear
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
gastroenterology
growth
paediatric practice
coeliac disease
Megjelenés:Archives Of Disease In Childhood. - 105 : 10 (2020), p. 964-968. -
További szerzők:Stellato, Pio Bruzzese, Dario Cielo, Donatella Chiurazzi, Alfredo Galatola, Martina Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Crespo-Escobar, Paula Gyimesi Judit Hartman, Corina Kolaček, Sanja Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Mearin, Maria Luisa Meijer, Caroline R. Pieścik-Lech, Magorzata Polanco, Isabel Ribes-Koninckx, Carmen Shamir, Raanan (gyermekgyógyász) Szajewska, Hania (gyermekgyógyász) Troncone, Riccardo Greco, Luigi
Pályázati támogatás:EU- FP6-2005- FOOD4B- contract no. 03638
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2.

001-es BibID:BIBFORM057430
Első szerző:Auricchio, Renata
Cím:The frequency of coeliac disease (CD) in high-risk young children from families with CD : the Preventcd cohort / R. Auricchio, C. Hogen Esch, G. Castillejo, E. Mummert, E. Bravi, I. Korponay-Szabo, S. Koletzko, L. Greco, R. Troncone, M. L. Mearin, The PreventCD Study Group
Dátum:2011
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:Journal of Pediatric Gastroenterology and Nutrition 52 : Suppl. 2 (2011), p. E7. -
További szerzők:Hogen Esch, Caroline Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Mummert, Eckart Bravi, Enzo (biológus) Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Koletzko, Sibylle Greco, Luigi Troncone, Riccardo Mearin, Maria Luisa the PREVENTCD Study Group
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3.

001-es BibID:BIBFORM096515
035-os BibID:(cikkazonosító)1335 (WOS)000548695200001 (Scopus)85087496778
Első szerző:Benítez-Páez, Alfonso
Cím:Breast-Milk Microbiota Linked to Celiac Disease Development in Children : a Pilot Study From the PreventCD Cohort / Benítez-Páez Alfonso, Olivares Marta, Szajewska Hania, Piescik-Lech Magorzata, Polanco Isabel, Castillejo Gemma, Nunez Merce, Ribes-Koninckx Carmen, Korponay-Szabó Ilma R., Koletzko Sibylle, Meijer Caroline R., Mearin M. Luisa, Sanz Yolanda
Dátum:2020
ISSN:1664-302X
Megjegyzések:Celiac disease (CeD) is an immune-mediated disorder triggered by exposure to dietary gluten proteins in genetically predisposed individuals. In addition to the host genome, the microbiome has recently been linked to CeD risk and pathogenesis. To progress in our understanding of the role of breast milk microbiota profiles in CeD, we have analyzed samples from a sub-set of mothers (n = 49) included in the PreventCD project, whose children did or did not develop CeD. The results of the microbiota data analysis indicated that neither the BMI, HLA-DQ genotype, the CeD condition nor the gluten-free diet of the mothers could explain the human milk microbiota profiles. Nevertheless, we found that origin country, the offspring's birth date and, consequently, the milk sampling date influenced the abundance and prevalence of microbes in human milk, undergoing a transition from an anaerobic to a more aerobic microbiota, including potential pathogenic species. Furthermore, certain microbial species were more abundant in milk samples from mothers whose children went on to develop CeD compared to those that remained healthy. These included increases in facultative methylotrophs such as Methylobacterium komagatae and Methylocapsa palsarum as well as in species such as Bacteroides vulgatus, that consumes fucosylated-oligosaccharides present in human milk, and other breast-abscess associated species. Theoretically, these microbiota components could be vertically transmitted from mothers-to-infants during breastfeeding, thereby influencing CeD risk
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
breast milk
HLA genotype
celiac disease
children
human milk microbiota
mothers
Megjelenés:Frontiers in Microbiology. - 11 (2020), p. 1-12. -
További szerzők:Olivares, Marta Szajewska, Hania (gyermekgyógyász) Pieścik-Lech, Magorzata Polanco, Isabel Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Nuňez, Merce Ribes-Koninckx, Carmen Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Koletzko, Sibylle Meijer, Caroline R. Mearin, Maria Luisa Sanz, Yolanda
Pályázati támogatás:FP6-2005-FOOD-4B-36383?PREVENTCD
Egyéb
101788
OTKA
TAMOP 2.2.11/1/KONV20 12-0023
TÁMOP
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4.

001-es BibID:BIBFORM072048
Első szerző:Borrelli, M.
Cím:Intestinal anti-transglutaminase 2 immunoglobulin A deposits in children at risk for coeliac disease (CD) : data from the PreventCD study / Borrelli M., Maglio M., Korponay-Szabó I. R., Vass V., Mearin M. L., Meijer C., Niv-Drori H., Ribes-Koninckx C., Roca M., Shamir R., Troncone R., Auricchio R.
Dátum:2018
ISSN:0009-9104
Megjegyzések:In coeliac disease (CD), anti-tissue transglutaminase 2 immunoglobulin(Ig)A antibodies (anti-TG2) are produced and deposited in the intestine.PreventCD (www.preventcd.com) is a European multi-centre study, whichinvestigates the influence of infant nutrition and that of genetic,immunological and other environmental factors on the risk of developingCD. The aim of the current study was to evaluate the appearance ofintestinal anti-TG2 deposits in very early intestinal biopsies from at-riskinfants and their predictive value for villous atrophy. Sixty-five small bowelbiopsies, performed in 62 children, were investigated for the presenceof intestinal anti-TG2 extracellular IgA deposits by using doubleimmunofluorescence. The biopsies were performed in the presence ofelevated serum levels of CD-associated antibodies and/or symptomssuggesting disease. Deposits of anti-TG2 IgA were present in 53 of 53 CDpatients and three of three potential CD patients. In potential CD patients,mucosal deposits showed a patchy distribution characterized by some areascompletely negative, whereas active CD patients had uniformly present andevident mucosal deposits. Only one of six patients without CD (negative forserum anti-TG2 and with normal mucosa) had intestinal deposits with apatchy distribution and a weak staining. Two of the 53 CD patients receiveda definitive diagnosis of CD after a second or third biopsy; mucosal depositsof anti-TG2 IgA were evaluated in all samples. Before developing villous atrophy, both patients had anti-TG2 deposits in normal mucosalarchitecture, antibodies in one patient being absent in serum. We demonstrated that in CD the intestinal deposits of anti-TG2 are a constant presence and appear very early in the natural history of disease.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
celiac
Megjelenés:Clinical And Experimental Immunology. - 191 : 3 (2018), p. 311-317. -
További szerzők:Maglio, M. Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Vass V. Mearin, Maria Luisa Meijer, Caroline R. Niv-Drori, H. Ribes-Koninckx, Carmen Roca, María Shamir, R. Troncone, Riccardo Auricchio, Renata
Pályázati támogatás:GINOP-2.3.2-15-2016-00015
GINOP
NKFI-120392
NKFI
OTKA-101788
OTKA
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5.

001-es BibID:BIBFORM044302
Első szerző:Collin, Pekka
Cím:Antiendomysial and antihuman recombinant tissue transglutaminase antibodies in the diagnosis of coeliac disease : a biopsy-proven European multicentre study / Collin Pekka, Kaukinen Katri, Vogelsang Harald, Korponay-Szabo Ilma, Sommer Rudolf, Schreier Elisabeth, Volta Umberto, Granito Alessandro, Veronesi Lorenza, Mascart Francoise, Ocmant Annick, Ivarsson Anneli, Lagerqvist Carina, Bürgin-Wolff Annemarie, Hadziselimovic Faruk, Furlano Raoul I., Sidler Marc A., Mulder Chris J. J., Goerres Marije S., Mearin M. Luisa, Ninaber Maarten K., Gudmand-Hoyer Eivind, Fabiani Elisabetta, Catassi Carlo, Tidlund Helena, Alainentalo Lisbeth, Maki Markku
Dátum:2005
ISSN:0954-691X
Megjegyzések:OBJECTIVE:To investigate the value of serum antitissue transglutaminase IgA antibodies (IgA-TTG) and IgA antiendomysial antibodies (IgA-EMA) in the diagnosis of coeliac disease in cohorts from different geographical areas in Europe. The setting allowed a further comparison between the antibody results and the conventional small-intestinal histology.METHODS:A total of 144 cases with coeliac disease [median age 19.5 years (range 0.9-81.4)], and 127 disease controls [median age 29.2 years (range 0.5-79.0)], were recruited, on the basis of biopsy, from 13 centres in nine countries. All biopsy specimens were re-evaluated and classified blindly a second time by two investigators. IgA-TTG were determined by ELISA with human recombinant antigen and IgA-EMA by an immunofluorescence test with human umbilical cord as antigen.RESULTS:The quality of the biopsy specimens was not acceptable in 29 (10.7%) of 271 cases and a reliable judgement could not be made, mainly due to poor orientation of the samples. The primary clinical diagnosis and the second classification of the biopsy specimens were divergent in nine cases, and one patient was initially enrolled in the wrong group. Thus, 126 coeliac patients and 106 controls, verified by biopsy, remained for final analysis. The sensitivity of IgA-TTG was 94% and IgA-EMA 89%, the specificity was 99% and 98%, respectively.CONCLUSIONS:Serum IgA-TTG measurement is effective and at least as good as IgA-EMA in the identification of coeliac disease. Due to a high percentage of poor histological specimens, the diagnosis of coeliac disease should not depend only on biopsy, but in addition the clinical picture and serology should be considered
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:European Journal Of Gastroenterology & Hepatology. - 17 : 1 (2005), p. 85-91. -
További szerzők:Kaukinen, Katri Vogelsang, Harald Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Sommer, Rudolf Schreier, Elisabeth Volta, Umberto Granito, Alessandro Veronesi, Lorenza Mascart, Francoise Ocmant, Annick Ivarsson, Anneli Lagerqvist, Carina Bürgin-Wolff, Annemarie Hadziselimovic, Faruk Furlano, Raoul I. Sidler, Marc A. Mulder, Chris J. Goerres, Marije S. Mearin, Maria Luisa Ninaber, Maarten K. Gudmand-Hoyer, Eivind Fabiani, Elisabetta Catassi, Carlo Tidlund, Helena Alainentalo, Lisbeth Mäki, Markku
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6.

001-es BibID:BIBFORM069474
Első szerző:Crespo-Escobar, Paula
Cím:The role of gluten consumption at an early age in celiac disease development : a further analysis of the prospective PreventCD cohort study / Crespo-Escobar Paula, Mearin Maria Luisa, Hervás David, Auricchio Renata, Castillejo Gemma, Gyimesi Judit, Martinez-Ojinaga Eva, Werkstetter Katharina, Vriezinga Sabine Lisa, Korponay-Szabo Ilma Rita, Polanco Isabel, Troncone Riccardo, Stoopman Els, Kolaček Sanja, Shamir Raanan, Szajewska Hania, Koletzko Sibylle, Ribes-Koninckx Carmen
Dátum:2017
ISSN:0002-9165
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:American Journal of Clinical Nutrition 105 : 4 (2017), p. 890-896. -
További szerzők:Mearin, Maria Luisa Hervás, David Auricchio, Renata Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Gyimesi Judit Martinez-Ojinaga, Eva Werkstetter, Katharina (gyermekgyógyász, gasztroenterológus) Vriezinga, Sabine Lisa (gyermekgyógyász) Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Polanco, Isabel Troncone, Riccardo Stoopman, Els Kolaček, Sanja Shamir, Raanan (gyermekgyógyász) Szajewska, Hania (gyermekgyógyász) Koletzko, Sibylle Ribes-Koninckx, Carmen
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7.

001-es BibID:BIBFORM016242
Első szerző:Dubois, Patrick C. A.
Cím:Multiple common variants for celiac disease influencing immune gene expression / Dubois Patrick C. A., Trynka Gosia, Franke Lude, Hunt Karen A., Romanos Jihane, Curtotti Alessandra, Zhernakova Alexandra, Heap Graham A. R., Ádány Róza, Aromaa Arpo, Bardella Maria Teresa, van den Berg Leonard H., Bockett Nicholas A., de la Concha Emilio G., Dema Bárbara, Fehrmann Rudolf S. N., Fernández-Arquero Miguel, Fiatal Szilvia, Grandone Elvira, Green Peter M., Groen Harry J. M., Gwilliam Rhian, Houwen Roderick H. J., Hunt Sarah E., Kaukinen Katri, Kelleher Dermot, Korponay-Szabo Ilma, Kurppa Kalle, MacMathuna Padraic, Mäki Markku, Mazzilli Maria Cristina, McCann Owen T., Mearin M. Luisa, Mein Charles A., Mirza Muddassar M., Mistry Vanisha, Mora Barbara, Morley Katherine I., Mulder Chris J., Murray Joseph A., Núnez Concepción, Oosterom Elvira, Ophoff Roel A., Polanco Isabel, Peltonen Leena, Platteel Mathieu, Rybak Anna, Salomaa Veikko, Schweizer Joachim J., Sperandeo Maria Pia, Tack Greetje J., Turner Graham, Veldink Jan H., Verbeek Wieke H. M., Weersma Rinse K., Wolters Victorien M., Urcelay Elena, Cukrowska Bozena, Greco Luigi, Neuhausen Susan L., McManus Ross, Barisani Donatella, Deloukas Panos, Barrett Jeffrey C., Saavalainen Paivi, Wijmenga Cisca, van Heel David A.
Dátum:2010
ISSN:1061-4036
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Nature Genetics. - 42 : 4 (2010), p. 295-302. -
További szerzők:Trynka, Gosia Franke, Lude Hunt, Karen A. Romanos, Jihane Curtotti, Alessandra Zhernakova, Alexandra Heap, Graham A. R. Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Aromaa, Arpo Bardella, Maria Teresa Van den Berg, Leonard H. Bockett, Nicholas A. Concha, Emilio G., de la Dema, Bárbara Fehrmann, Rudolf S. N. Fernández-Arquero, Miguel Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Grandone, Elvira Green, Peter M. Groen, Harry J. M. Gwilliam, Rhian Houwen, Roderick H. J. Hunt, Sarah E. Kaukinen, Katri Kelleher, Dermot Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Kurppa, Kalle MacMathuna, Padraic Mäki, Markku Mazzilli, Maria Cristina McCann, Owen T. Mearin, Maria Luisa Mein, Charles A. Mirza, Muddassar M. Mistry, Vanisha Mora, Barbara Morley, Katherine I. Mulder, Chris J. Murray, Joseph A. Núnez, Concepción Oosterom, Elvira Ophoff, Roel A. Polanco, Isabel Peltonen, Leena Platteel, Mathieu Rybak, Anna Salomaa, Veikko Schweizer, Joachim J. Sperandeo, Maria Pia Tack, Greetje J. Turner, Graham Veldink, Jan H. Verbeek, Wieke H. M. Weersma, Rinse K. Wolters, Victorien M. Urcelay, Elena Cukrowska, Bozena Greco, Luigi Neuhausen, Susan L. McManus, Ross Barisani, Donatella Deloukas, Panos Barrett, Jeffrey C. Saavalainen, Päivi Wijmenga, Cisca Heel, David A., van
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8.

001-es BibID:BIBFORM044276
Első szerző:Einarsdottir, Elisabet
Cím:Multiple independent variants in 6q21-22 associated with susceptibility to celiac disease in the Dutch, Finnish and Hungarian populations / Einarsdottir Elisabet, Bevova Marianna R., Zhernakova Alexandra, Monsuur Alienke, Koskinen Lotta L. E., van't Slot Ruben, Mulder Chris, Mearin M. Luisa, Korponay-Szabo Ilma R., Kaukinen Katri, Kurppa Kalle, Kere Juha, Mäki Markku, Wijmenga Cisca, Saavalainen Päivi
Dátum:2011
ISSN:1018-4813
Megjegyzések:Celiac disease is an inflammatory enteropathy caused by intolerance to gluten. Previous linkage studies in the Dutch, Finnish and Hungarian populations have revealed a locus on chromosome 6q21-22 conferring susceptibility to celiac disease. This locus has previously been implicated in susceptibility to other autoimmune diseases such as Crohn's disease and type 1 diabetes. We performed fine mapping on 446 independent individuals with celiac disease and 641 controls of Dutch origin, testing 872 tagging SNPs in a 22 Mb region of chromosome 6. The 12 most promising SNPs were followed up in 2071 individuals from 284 Finnish and 357 Hungarian celiac disease families to identify risk variants in this region. Multiple markers in the region were significantly associated with celiac disease in the Dutch material. Two SNPs, rs9391227 and rs4946111, were significantly associated with celiac disease in the Finnish population. The association to rs9391227 represents the strongest association signal found in the Finnish (P = 0.003, OR 0.66) as well as the combined Dutch, Finnish and Hungarian populations (P = 3.6 ? 10(-5), OR 0.76). The rs9391227 is situated downstream of the HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 (HACE1) gene and is contained within a region of strong linkage disequilibrium enclosing HACE1. Two additional, independent, susceptibility variants in the 6q21-22 region were also found in a meta-analysis of the three populations. The 6q21-22 region was confirmed as a celiac disease susceptibility locus and harbors multiple independent associations, some of which may implicate ubiquitin-pathways in celiac disease susceptibility.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:European Journal Of Human Genetics. - 19 : 6 (2011), p. 682-686. -
További szerzők:Bevova, Marianna R. Zhernakova, Alexandra Monsuur, Alienke Koskinen, Lotta L. E. van't Slot, Ruben Mulder, Chris J. Mearin, Maria Luisa Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Kaukinen, Katri Kurppa, Kalle Kere, Juha Mäki, Markku Wijmenga, Cisca Saavalainen, Päivi
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9.

001-es BibID:BIBFORM096510
035-os BibID:(cikkazonosító)e0197713 (WoS)000487964600088 (Scopus)85071754922
Első szerző:Grunewald, Maria
Cím:Variation and Interdependencies of Human Milk Macronutrients, Fatty Acids, Adiponectin, Insulin, and IGF-II in the European PreventCD Cohort / Grunewald M., Hellmuth C., Kirchberg F. F., Mearin M. L., Auricchio R., Castillejo G., Korponay-Szabo I. R., Polanco I., Roca M., Vriezinga S. L., Werkstetter K., Koletzko B., Demmelmair H.
Dátum:2021
ISSN:2072-6643
Megjegyzések:Background & aims: Breastfeeding is beneficial for mothers and infants. Underlying mechanisms and biochemical mediators thus need to be investigated to develop and support improved infant nutrition practices promoting the child health. We analysed the relation between maternal breast milk composition and infant metabolism. Methods: 196 pairs of mothers and infants from a European research project (PreventCD) were studied. Maternal milk samples collected at month 1 and month 4 after birth were analysed for macronutrient classes, hormone, and fatty acid (FA) content. Phospholipids, acylcarnitines, and amino acids were measured in serum samples of 4-month old infants. Associations between milk components and infant metabolites were analysed with spearman correlation and linear mixed effect models (LME). P-values were corrected for multiple testing (PLME). Results: Month 1 milk protein content was strongly associated with infant serum lyso-phosphatidylcholine (LPC) 14:0 (PLME = 0.009). Month 1 milk insulin was associated to infant acetylcarnitine (PLME = 0.01). There were no associations between milk protein content and serum amino acids and milk total fat content and serum polar lipids. Middle- and odd-chain FA% in breast milk at both ages were significantly related to serum LPC and sphingomyelins (SM) species in infant serum (all PLME<0.05), while FA% 20:5n-3 and 22:6n-3 percentages were significantly associated to serum LPC 22:6 (PLME = 1.91?10-4/7.93?10-5) in milk only at month 4. Other polyunsaturated fatty acids and hormones in milk showed only weak associations with infant serum metabolites. Conclusions: Infant serum LPC are influenced by breast milk FA composition and, intriguingly, milk protein content in early but not late lactation. LPC 14:0, previously found positively associated with obesity risk, was the serum metabolite which was the most strongly associated to milk protein content. Thus, LPC 14:0 might be a key metabolite not only reflecting milk protein intake in infants, but also relating high protein content in milk or infant formula to childhood obesity risk
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
breast milk
coeliac disease
Megjelenés:Nutrients. - 13 : 6 (2021), p. 1-19. -
További szerzők:Hellmuth, Christian Kirchberg, Franca F. Mearin, Maria Luisa Auricchio, Renata Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Polanco, Isabel Roca, María Vriezinga, Sabine Lisa (gyermekgyógyász) Werkstetter, Katharina (gyermekgyógyász, gasztroenterológus) Koletzko, Berthold Demmelmair, Hans
Pályázati támogatás:OTKA-101788
OTKA
NKFIH 120392
OTKA
TAMOP 2.2.11/1/KONV-2012-002
TÁMOP
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10.

001-es BibID:BIBFORM077371
035-os BibID:(cikkazonosító)e0197713 (WOS)000433900800036 (Scopus)85048036551
Első szerző:Hellmuth, Christian
Cím:The impact of human breast milk components on the infant metabolism / Hellmuth Christian, Uhl Olaf, Demmelmair Hans, Grunewald Maria, Auricchio Renata, Castillejo Gemma, Korponay-Szabo Ilma R., Polanco Isabel, Roca María, Vriezinga Sabine L., Werkstetter Katharina J., Koletzko Berthold, Mearin M. Luisa, Kirchberg Franca F.
Dátum:2018
ISSN:1932-6203
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Plos One. - 13 : 6 (2018), p. 1-19. -
További szerzők:Uhl, Olaf Demmelmair, Hans Grunewald, Maria Auricchio, Renata Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Polanco, Isabel Roca, María Vriezinga, Sabine Lisa (gyermekgyógyász) Werkstetter, Katharina (gyermekgyógyász, gasztroenterológus) Koletzko, Berthold Mearin, Maria Luisa Kirchberg, Franca F.
Pályázati támogatás:A101788
OTKA
TAMOP 2.2.11/1/KONV-2012-0023
TÁMOP
NKFI120392
NKFIH
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DOI
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11.

001-es BibID:BIBFORM091976
Első szerző:Husby, Steffen
Cím:European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease 2020 / Steffen Husby, Sibylle Koletzko, Ilma Korponay-Szabó, Kalle Kurppa, Maria Luisa Mearin, Carmen Ribes-Koninckx, Raanan Shamir, Riccardo Troncone, Renata Auricchio, Gemma Castillejo, Robin Christensen, Jernej Dolinsek, Peter Gillett, Asbjørn Hróbjartsson, Tunde Koltai, Markku Maki, Sabrina Mai Nielsen, Alina Popp, Ketil Størdal, Katharina Werkstetter, Margreet Wessels
Dátum:2020
ISSN:0277-2116
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal of pediatric gastroenterology and nutrition. - 70 : 1 (2020), p. 141-156. -
További szerzők:Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Kurppa, Kalle Mearin, Maria Luisa Ribes-Koninckx, Carmen Shamir, Raanan (gyermekgyógyász) Troncone, Riccardo Auricchio, Renata Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Christensen, Robin Dolinśek, Jernej Gillett, Peter Hróbjartsson, Asbjørn Koltai Tünde Mäki, Markku Nielsen, Sabrina Mai Popp, Alina Størdal, Ketil Werkstetter, Katharina (gyermekgyógyász, gasztroenterológus) Wessels, Margreet
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

12.

001-es BibID:BIBFORM044266
Első szerző:Husby, Steffen
Cím:European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease / Husby, S., Koletzko, S., Korponay-Szabó, I. R., Mearin, M. L., Phillips, A., Shamir, R., Troncone, R., Giersiepen, K., Branski, D., Catassi, C., Lelgeman, M., Mäki, M., Ribes-Koninckx, C., Ventura, A., Zimmer, K. P., the ESPGHAN Working Group on Coeliac Disease Diagnosis, the ESPGHAN Gastroenterology Committee
Dátum:2012
ISSN:0277-2116
Megjegyzések:OBJECTIVE: Diagnostic criteria for coeliac disease (CD) from the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) were published in 1990. Since then, the autoantigen in CD, tissue transglutaminase, has been identified; the perception of CD has changed from that of a rather uncommon enteropathy to a common multiorgan disease strongly dependent on the haplotypes human leukocyte antigen (HLA)-DQ2 and HLA-DQ8; and CD-specific antibody tests have improved.METHODS:A panel of 17 experts defined CD and developed new diagnostic criteria based on the Delphi process. Two groups of patients were defined with different diagnostic approaches to diagnose CD: children with symptoms suggestive of CD (group 1) and asymptomatic children at increased risk for CD (group 2). The 2004 National Institutes of Health/Agency for Healthcare Research and Quality report and a systematic literature search on antibody tests for CD in paediatric patients covering the years 2004 to 2009 was the basis for the evidence-based recommendations on CD-specific antibody testing.RESULTS:In group 1, the diagnosis of CD is based on symptoms, positive serology, and histology that is consistent with CD. If immunoglobulin A anti-tissue transglutaminase type 2 antibody titers are high (>10 times the upper limit of normal), then the option is to diagnose CD without duodenal biopsies by applying a strict protocol with further laboratory tests. In group 2, the diagnosis of CD is based on positive serology and histology. HLA-DQ2 and HLA-DQ8 testing is valuable because CD is unlikely if both haplotypes are negative.CONCLUSIONS:The aim of the new guidelines was to achieve a high diagnostic accuracy and to reduce the burden for patients and their families. The performance of these guidelines in clinical practice should be evaluated prospectively.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
celiac disease
Megjelenés:Journal Of Pediatric Gastroenterology And Nutrition 54 : 1 (2012), p. 136-160. -
További szerzők:Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Mearin, Maria Luisa Phillips, A. Shamir, R. Troncone, Riccardo Giersiepen, Klaus Branski, D. Catassi, Carlo Lelgemann, Monika Mäki, Markku Ribes-Koninckx, Carmen Ventura, Alessandro Zimmer, Klaus-Peter the ESPGHAN Working Group on Coeliac Disease Diagnosis the ESPGHAN Gastroenterology Committee
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