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1.
001-es BibID:
BIBFORM016242
Első szerző:
Dubois, Patrick C. A.
Cím:
Multiple common variants for celiac disease influencing immune gene expression / Dubois Patrick C. A., Trynka Gosia, Franke Lude, Hunt Karen A., Romanos Jihane, Curtotti Alessandra, Zhernakova Alexandra, Heap Graham A. R., Ádány Róza, Aromaa Arpo, Bardella Maria Teresa, van den Berg Leonard H., Bockett Nicholas A., de la Concha Emilio G., Dema Bárbara, Fehrmann Rudolf S. N., Fernández-Arquero Miguel, Fiatal Szilvia, Grandone Elvira, Green Peter M., Groen Harry J. M., Gwilliam Rhian, Houwen Roderick H. J., Hunt Sarah E., Kaukinen Katri, Kelleher Dermot, Korponay-Szabo Ilma, Kurppa Kalle, MacMathuna Padraic, Mäki Markku, Mazzilli Maria Cristina, McCann Owen T., Mearin M. Luisa, Mein Charles A., Mirza Muddassar M., Mistry Vanisha, Mora Barbara, Morley Katherine I., Mulder Chris J., Murray Joseph A., Núnez Concepción, Oosterom Elvira, Ophoff Roel A., Polanco Isabel, Peltonen Leena, Platteel Mathieu, Rybak Anna, Salomaa Veikko, Schweizer Joachim J., Sperandeo Maria Pia, Tack Greetje J., Turner Graham, Veldink Jan H., Verbeek Wieke H. M., Weersma Rinse K., Wolters Victorien M., Urcelay Elena, Cukrowska Bozena, Greco Luigi, Neuhausen Susan L., McManus Ross, Barisani Donatella, Deloukas Panos, Barrett Jeffrey C., Saavalainen Paivi, Wijmenga Cisca, van Heel David A.
Dátum:
2010
ISSN:
1061-4036
Tárgyszavak:
Orvostudományok
Egészségtudományok
idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:
Nature Genetics. - 42 : 4 (2010), p. 295-302. -
További szerzők:
Trynka, Gosia
Franke, Lude
Hunt, Karen A.
Romanos, Jihane
Curtotti, Alessandra
Zhernakova, Alexandra
Heap, Graham A. R.
Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Aromaa, Arpo
Bardella, Maria Teresa
Van den Berg, Leonard H.
Bockett, Nicholas A.
Concha, Emilio G., de la
Dema, Bárbara
Fehrmann, Rudolf S. N.
Fernández-Arquero, Miguel
Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember)
Grandone, Elvira
Green, Peter M.
Groen, Harry J. M.
Gwilliam, Rhian
Houwen, Roderick H. J.
Hunt, Sarah E.
Kaukinen, Katri
Kelleher, Dermot
Korponay-Szabó Ilma (1959-) (gyermekgyógyász)
Kurppa, Kalle
MacMathuna, Padraic
Mäki, Markku
Mazzilli, Maria Cristina
McCann, Owen T.
Mearin, Maria Luisa
Mein, Charles A.
Mirza, Muddassar M.
Mistry, Vanisha
Mora, Barbara
Morley, Katherine I.
Mulder, Chris J.
Murray, Joseph A.
Núnez, Concepción
Oosterom, Elvira
Ophoff, Roel A.
Polanco, Isabel
Peltonen, Leena
Platteel, Mathieu
Rybak, Anna
Salomaa, Veikko
Schweizer, Joachim J.
Sperandeo, Maria Pia
Tack, Greetje J.
Turner, Graham
Veldink, Jan H.
Verbeek, Wieke H. M.
Weersma, Rinse K.
Wolters, Victorien M.
Urcelay, Elena
Cukrowska, Bozena
Greco, Luigi
Neuhausen, Susan L.
McManus, Ross
Barisani, Donatella
Deloukas, Panos
Barrett, Jeffrey C.
Saavalainen, Päivi
Wijmenga, Cisca
Heel, David A., van
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2.
001-es BibID:
BIBFORM048562
Első szerző:
Tack, Greetje J.
Cím:
Consumption of gluten with gluten-degrading enzyme by celiac patients : a pilot-study / Greetje J. Tack, Jolanda M. W. van de Water, Maaike J. Bruins, Engelina M. C. Kooy-Winkelaar, Jeroen van Bergen, Petra Bonnet, Anita C. E. Vreugdenhil, Ilma Korponay-Szabo, Luppo Edens, B. Mary E. von Blomberg, Marco W. J. Schreurs, Chris J. Mulder, Frits Koning
Dátum:
2013
ISSN:
1007-9327
Megjegyzések:
AIM:To assesses the safety and efficacy of Aspergillus niger prolyl endoprotease (AN-PEP) to mitigate the immunogenic effects of gluten in celiac patients.METHODS:Patients with initial diagnosis of celiac disease as confirmed by positive serology with subtotal or total villous atrophy on duodenal biopsies who adhere to a strict gluten-free diet (GFD) resulting in normalised antibodies and mucosal healing classified as Marsh 0 or I were included. In a randomised double-blind placebo-controlled pilot study, patients consumed toast (approximately 7 g/d gluten) with AN-PEP for 2 wk (safety phase). After a 2-wk washout period with adherence of the usual GFD, 14 patients were randomised to gluten intake with either AN-PEP or placebo for 2 wk (efficacy phase). Measurements at baseline included complaints, quality-of-life, serum antibodies, immunophenotyping of T-cells and duodenal mucosa immunohistology. Furthermore, serum and quality of life questionnaires were collected during and after the safety, washout and efficacy phase. Duodenal biopsies were collected after the safety phase and after the efficacy phase. A change in histological evaluation according to the modified Marsh classification was the primary endpoint.RESULTS:In total, 16 adults were enrolled in the study. No serious adverse events occurred during the trial and no patients withdrew during the trial. The mean score for the gastrointestinal subcategory of the celiac disease quality (CDQ) was relatively high throughout the study, indicating that AN-PEP was well tolerated. In the efficacy phase, the CDQ scores of patients consuming gluten with placebo or gluten with AN-PEP did not significantly deteriorate and moreover no differences between the groups were observed. During the efficacy phase, neither the placebo nor the AN-PEP group developed significant antibody titers. The IgA-EM concentrations remained negative in both groups. Two patients were excluded from entering the efficacy phase as their mucosa showed an increase of two Marsh steps after the safety phase, yet with undetectable serum antibodies, while 14 patients were considered histologically stable on gluten with AN-PEP. Also after the efficacy phase, no significant deterioration was observed regarding immunohistological and flow cytometric evaluation in the group consuming placebo compared to the group receiving AN-PEP. Furthermore, IgA-tTG deposit staining increased after 2 wk of gluten compared to baseline in four out of seven patients on placebo. In the seven patients receiving AN-PEP, one patient showed increased and one showed decreased IgA-tTG deposits.CONCLUSION:AN-PEP appears to be well tolerated. However, the primary endpoint was not met due to lack of clinical deterioration upon placebo, impeding an effect of AN-PEP.
Tárgyszavak:
Orvostudományok
Elméleti orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
Adverse events
Aspergillus niger prolyl endoprotease
Celiac disease
Enzyme
IgA-tTG intestinal deposits
Prolyl endoprotease
Megjelenés:
World Journal of Gastroenterology 19 : 35 (2013), p. 5837-5847. -
További szerzők:
Water, Jolanda M. W. van de
Bruins, Maaike J.
Kooy-Winkelaar, Engelina M. C.
Bergen, Jeroen van
Bonnet, Petra
Vreugdenhil, Anita C. E.
Korponay-Szabó Ilma (1959-) (gyermekgyógyász)
Edens, Luppo
Blomberg, B. Mary E. von
Schreurs, Marco W. J.
Mulder, Chris J.
Koning, Frits
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DOI
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