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001-es BibID:	BIBFORM044309
Első szerző:	Korponay-Szabó Ilma (gyermekgyógyász)
Cím:	Prospective significance of antiendomysium antibody positivity in subsequently verified celiac disease / Korponay-Szabó I. R., B. Kovács J., Lörincz M., Gorácz G., Szabados K., Balogh M.
Dátum:	1997
Megjegyzések:	BACKGROUND: In order to assess their long-term predictability for the diagnosisof celiac disease, antiendomysium antibody results were compared with the outcomeof the Interlaken diagnostic process. METHODS: Prospective gluten challenge was performed in 153 children withpreviously diagnosed flat small-intestine mucosa. In 90 patients (Group A),endomysium antibodies were initially positive, in seven (Group B) they werenegative, and 56 patients (Group C) had no initial serological results. InIgA-deficient persons, IgG antibodies were also assayed, both by theimmunofluorescent method. RESULTS: Histological relapse rates were 100% (90/90), 14.3% (1/7), and 76.8%(43/56), p < 0.001, in Groups A, B, and C, respectively. Each patient withrelapse also exhibited endomysium antibody positivity during the challenge.Patients in whom celiac disease could be finally ruled out remained consistently endomysium-antibody negative. The celiac disease patient in Group B had severesecondary immunoglobulin deficiency at entry, which explained the initialnegativity. Diagnosis based on antiendomysium antibody positivity and flat mucosagave a higher applicability (92.8 vs. 50.3%) and reliability (relapse rate 100vs. 89.6%) than the 1990 European Society of Paediatric Gastroenterology andNutrition (ESPGAN) criteria among these patients. CONCLUSIONS: Endomysium antibody positivity at presentation has been found to be as useful as gluten challenge in the diagnosis of celiac disease, even inpatients under the age of 2 years. Challenge is still advisable in patients with a flat small intestinal mucosa when antiendomysium antibody results are negative or have not been done, as among these patients significantly lower relapse rates were found.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Pediatric Gastroenterology and Nutrition. - 25 : 1 (1997), p. 56-63. -
További szerzők:	B. Kovács Judit Lőrincz Margit Gorácz Gyula Szabados Katalin Balogh Márta
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM023715
Első szerző:	Nemes Éva (csecsemő- és gyermekgyógyász, gasztroenterológus)
Cím:	Gluten intake interferes with the humoral immune response to recombinant hepatitis B vaccine in patients with celiac disease / Nemes É., Lefler É., Szegedi L., Kapitány A., B. Kovács J., Balogh M., Szabados K., Tumpek J., Sipka S., Korponay-Szabó I. R.
Dátum:	2008
ISSN:	0031-4005
Megjegyzések:	Patients with celiac disease, who often carry human leukocyte antigen-DR3;DQ2, are prone to inadequate response to hepatitis B immunization. We evaluated vaccine response in relation to disease activity and whether previous treatment with a gluten-free diet influences the achievement of protective antibody titers. PATIENTS AND METHODS: We studied 128 children and adolescents with celiac disease and 113 age-matched control subjects. Twenty-two patients with celiac disease were prospectively immunized after diagnosis during dietary treatment (group 1). A total of 106 (group 2) and the control subjects received vaccination by mass immunization in schools at 14 years of age regardless of diet status and when celiac disease was still undiagnosed in 27 of these children. Diet compliance and celiac disease activity were monitored by measurement of antibodies against transglutaminase and endomysium. Vaccine response was determined by measuring antihepatitis B antibodies from serum. RESULTS: The seroconversion after hepatitis B vaccination was 95.5% in group 1. All of these patients carried human leukocyte antigen DQ2. The response rate in group 2 was 50.9% and correlated with gluten intake (untreated patients: 25.9%, non-strict diet: 44.4%, strict diet: 61.4%). Treated and compliant patients did not significantly differ from control subjects (75.2%). Thirty-seven antihepatitis B-negative patients with celiac disease received a booster during a controlled gluten-free diet, and 36 (97.3%) seroconverted, irrespective of the presence of human leukocyte antigen DQ2. CONCLUSIONS: Nonresponse to recombinant hepatitis B surface antigen may be a sign of undiagnosed celiac disease. However, there is a good vaccine response in adequately treated patients. Human leukocyte antigen DQ alleles do not seem to have a primary role. Revaccination is recommended during a controlled gluten-free diet.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Pediatrics. - 121 : 6 (2008), p. e1570-e1576. -
További szerzők:	Lefler Éva Szegedi László Kapitány Anikó (1979-) (molekuláris biológus) B. Kovács Judit Balogh Márta Szabados Katalin Tumpek Judit (1944-) (orvosi laboratóriumi szakorvos) Sipka Sándor (1945-) (laboratóriumi szakorvos) Korponay-Szabó Ilma (1959-) (gyermekgyógyász)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM096507
035-os BibID:	(cikkazonosító)9370397
Első szerző:	Riznik, Petra
Cím:	The Use of Biopsy and "No-Biopsy" Approach for Diagnosing Paediatric Coeliac Disease in the Central European Region / Riznik Petra, Balogh Márta, Bódi Piroska, De Leo Luigina, Dolinsek Jasmina, Guthy Ildikó, Gyimesi Judit, Horváth Ágnes, Kis Ildikó, Klemenak Martina, Koletzko Berthold, Koletzko Sibylle, Korponay-Szabó Ilma Rita, Krencnik Tomaz, Not Tarcisio, Palcevski Goran, Pollák Éva, Sblattero Daniele, Tokodi István, Vogrincic Matej, Werkstetter Katharina Julia, Dolinsek Jernej
Dátum:	2019
ISSN:	1687-6121 1687-630X
Megjegyzések:	Objectives: The current European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) guidelines introduced the option to diagnose coeliac disease (CD) in children and adolescents without upper endoscopy if the defined criteria are met. The aim of our study was to evaluate how frequently paediatric gastroenterologists in Central Europe used the "no-biopsy" approach and how often the duodenal biopsy could have been omitted. Methods: Medical records of patients aged < 19 years diagnosed with CD in 2016 from five European countries were analysed, focusing on levels of transglutaminase antibodies (TGA) at the time of diagnosis and on whether the diagnosis was confirmed using duodenal biopsy or "no-biopsy" approach. Clinical presentation and delays until final diagnosis were analysed according to diagnostic approach. Results: Data from 653 children (63.9% female, median age: 7 years, range: 7 months-18.5 years) from Croatia, Hungary, Germany, Italy, and Slovenia were analysed. One fifth (n = 134) of included children were asymptomatic at diagnosis. Of 519 symptomatic children, 107 (20.6%) were diagnosed by the "no-biopsy" approach. Out of the remaining 412 children who underwent duodenal biopsies, 214 (51.9%) had TGA ? 10 times upper level of normal (ULN) and would have been eligible for the "no-biopsy" approach. Signs and symptoms of malabsorption were more frequent in children diagnosed without duodenal biopsies. There were no differences in diagnostic delays with respect to the diagnostic approach. Conclusion: In this cohort, about 60% of symptomatic CD patients could have been diagnosed without duodenal biopsies. The aim of the "no-biopsy" approach was to make the diagnostic procedure less challenging without compromising its reliability. However, this option was applied only in 20%, in spite of fewer burdens to the family and reduced costs. The reasons for this discrepancy are unknown. Physicians should be made more aware about the reliability of CD diagnosis without biopsies when the ESPGHAN guidelines for CD diagnosis are followed
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk coeliac disease
Megjelenés:	Gastroenterology Research And Practice. - 2019 (2019), p. 1-6. -
További szerzők:	Balogh Márta Bodi Piroska De Leo, Luigina Dolinsek, Jasmina Guthy Ildikó Gyimesi Judit Horváth Ágnes (Veszprém) Kis Ildikó Klemenak, Martina Koletzko, Berthold Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Krencnik, Tomaz Not, Tarcisio Palcevski, Goran Pollák Éva Sblattero, Daniele Tokodi István Vogrincic, Matej Werkstetter, Katharina (gyermekgyógyász, gasztroenterológus) Dolinśek, Jernej
Pályázati támogatás:	NKFIH 120392 NKFIH EFOP-3.6.1-16-2016-00022 EFOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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