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001-es BibID:BIBFORM096521
035-os BibID:(WoS)000651551200033 (Scopus)85106198556
Első szerző:Görög A.
Cím:S2k guidelines (consensus statement) for diagnosis and therapy of dermatitis herpetiformis initiated by the European Academy of Dermatology and Venereology (EADV) / A. Görög, E. Antiga, M. Caproni, G. Cianchini, D. De, M. Dmochowski, J. Dolinsek, K. Drenovska, C. Feliciani, K. Hervonen, I. Lakos Jukic, Á. Kinyó, T. Koltai, I. Korponay-Szabó, A. V. Marzano, A. Patsatsi, C. Rose, T. Salmi, E. Schmidt, J. Setterfield, M. Shahid, C. Sitaru, S. Uzun, F. Valitutti, S. Vassileva, S. Yayli, M. Sárdy
Dátum:2021
ISSN:0926-9959
Megjegyzések:Introduction: Dermatitis herpetiformis (DH) is a chronic, pruritic, gluten-induced skin disorder characterized by subepidermal granular IgA deposition and a variable degree of enteropathy identical to that seen in coeliac disease. So far, there has been no European consensus about the management of DH. Methods: The guidelines were created by small subgroups of a guideline committee consisting of 26 specialists from various medical fields and one patients' representative. The members of the committee then discussed the guidelines and voted for the final version at two consensus meetings. The guidelines were developed under the support of the European Academy of Dermatology and Venereology (EADV) and in collaboration with the European Dermatology Forum (EDF). Results: The guidelines summarize evidence-based and expert-based recommendations (S2 level) for the management of DH (see Appendix). Conclusion: These guidelines will improve the quality of management of DH and support dermatologists in their diagnostic and therapeutic decisions.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
dermatitis herpetiformis
coeliac disease
Megjelenés:Journal of The European Academy of Dermatology And Venereology. - 35 : 6 (2021), p. 1251-1277. -
További szerzők:Antiga, E. Caproni, M. Cianchini, G. De, D. Dmochowski, M. Dolinśek, Jernej Drenovska, K. Feliciani, C. Hervonen, K. Lakos Jukic I. Kinyó Ágnes Koltai Tünde Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Marzano, Angelo V. Patsatsi, A. Rose, C. Salmi, T. T. Schmidt E. Setterfield, J. Shahid, M. Sitaru, C. Uzun, S. Valitutti, Francesco Vassileva, S. Yayli, S. Sárdy Miklós
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Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM044281
Első szerző:Koskinen, Outi
Cím:Gluten-dependent small bowel mucosal transglutaminase 2-specific IgA deposits in overt and mild enteropathy coeliac disease / Koskinen Outi, Collin Pekka, Korponay-Szabo Ilma, Salmi Teea, Iltanen Sari, Haimila Katri, Partanen Jukka, Mäki Markku, Kaukinen Katri
Dátum:2008
ISSN:0277-2116
Megjegyzések:OBJECTIVES: In coeliac disease, immunoglobulin (Ig)A-class autoantibodies against transglutaminase-2 are produced in the small intestinal mucosa, where they are deposited extracellularly. It remains unclear whether positive intestinal transglutaminase-2-targeted IgA deposits in subjects having normal small bowel mucosal morphology are signs of early-stage coeliac disease. We evaluated the gluten dependency of these deposits in overt and mild enteropathy coeliac disease.PATIENTS AND METHODS:All together 48 subjects suspected of coeliac disease but having normal small bowel mucosal villi were enrolled; 28 of them had latent coeliac disease. The remaining 20 having positive intestinal IgA deposits adopted a gluten-free diet before villous atrophy had developed. For comparison, 13 patients with overt coeliac disease and 42 noncoeliac controls were studied. Small bowel mucosal transglutaminase-2-specific autoantibodies were compared with villous morphology, intraepithelial lymphocyte densities, and serum coeliac autoantibodies.RESULTS:Intestinal IgA deposits were seen in all but 1 of the patients with latent coeliac disease, when the morphology was still intact; the intensity of these deposits increased as villous atrophy developed and decreased again on a gluten-free diet. In 20 patients with intestinal IgA deposits in normal villi, the intensity of the deposits decreased with the diet similarly to that seen in patients with overt coeliac disease. Mucosal IgA deposits were seen initially only in 5% of noncoeliac controls and in 8% after extended gluten consumption.CONCLUSIONS:The response of small bowel mucosal transglutaminase-2-specific IgA deposits for dietary intervention was similar in overt and mild enteropathy coeliac disease. Detection of such IgA deposits thus offers a good diagnostic tool to uncover early-stage coeliac disease.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Pediatric Gastroenterology And Nutrition. - 47 : 4 (2008), p. 436-442. -
További szerzők:Collin, Pekka Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Salmi, T. T. Iltanen, Sari Haimila, Katri Partanen, Jukka Mäki, Markku Kaukinen, Katri
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3.

001-es BibID:BIBFORM044282
Első szerző:Salmi, T. T.
Cím:Immunoglobulin A autoantibodies against transglutaminase 2 in the small intestinal mucosa predict forthcoming coeliac disease / Salmi T. T., Collin P., Järvinen O., Haimila K., Partanen J., Laurila K., Korponay-Szabo I. R., Huhtala H., Reunala T., Mäki M., Kaukinen K.
Dátum:2006
ISSN:0269-2813
Megjegyzések:BACKGROUND: Reliable markers of early developing coeliac diseases are needed. Coeliac autoantibodies in the serum or Marsh I inflammation may be indicators of subsequent coeliac disease.AIM:To investigate whether determination of intestinal transglutaminase 2-targeted autoantibody deposits would detect early developing coeliac disease better than previous methods.METHODS:The study investigated patients previously excluded for coeliac disease: 25 had positive serum coeliac autoantibodies (endomysial), 25 antibody-negative had Marsh I, and 25 antibody-negative had Marsh 0 finding. Seven (median) years after baseline investigation, new coeliac cases were recorded, and small bowel biopsy was offered to the rest of the patients. Serum and intestinal coeliac autoantibodies and intraepithelial lymphocytes were assessed as indicators of developing coeliac disease.RESULTS:Seventeen patients had developed coeliac disease: 13 in the autoantibody-positive group, three in the Marsh I group and one in the Marsh 0 group. At baseline, intestinal coeliac autoantibody deposits had a sensitivity and specificity of 93% and 93% in detecting subsequent coeliac disease, CD3+ 59% and 57%, gammadelta+ 76% and 60%, and villous tip intraepithelial lymphocytes 88% and 71%, respectively.CONCLUSIONS:Endomysial antibodies with normal histology indicates early developing coeliac disease. Transglutaminase 2-targeted intestinal autoantibody deposits proved the best predictor of subsequent coeliac disease
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Alimentary Pharmacology & Therapeutics. - 24 : 3 (2006), p. 541-552. -
További szerzők:Collin, P. Jarvinen, O. Haimila, Katri Partanen, Jukka Laurila, Kaija Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Huhtala, Heini Reunala, T. Mäki, Markku Kaukinen, Katri
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM019942
Első szerző:Salmi, T. T.
Cím:Endomysial antibody-negative coeliac disease : clinical characteristics and intestinal autoantibody deposits / T. T. Salmi, P. Collin, I. R. Korponay-Szabó, K. Laurila, J. Partanen, H. Huhtala, R. Király, L. Lorand, T. Reunala, M. Mäki, K. Kaukinen
Dátum:2006
ISSN:0017-5749
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Gut. - 55 : 12 (2006), p. 1746-1753. -
További szerzők:Collin, P. Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Laurila, Kaija Partanen, Jukka Huhtala, Heini Király Róbert (1975-) (biológus) Lorand, L. Reunala, T. Mäki, Markku Kaukinen, Katri
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Intézményi repozitóriumban (DEA) tárolt változat
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