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1.

001-es BibID:BIBFORM044340
Első szerző:Korponay-Szabó Ilma (gyermekgyógyász)
Cím:Milyen gyakori a coeliakia előfordulása a magyar népességben? / Korponay-Szabó I., Czinner A., B. Kovács J., Vámos A., Gorácz Gy., Szabó T.
Dátum:1997
Tárgyszavak:Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény hazai lapban
coeliakia
Megjelenés:Gyermekgyógyászat 48 : 3 (1997), p. 236-241. -
További szerzők:Czinner Antal B. Kovács Judit Vámos Adrienn Gorácz Gyula Szabó Terézia
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2.

001-es BibID:BIBFORM044310
Első szerző:Korponay-Szabó Ilma (gyermekgyógyász)
Cím:The human appendix : a composite substrate for anti-endomysium, anti-reticulin and anti-bowel antibody testing in coeliac disease / Ilma Rita Korponay-Szabó, Judit B. Kovács, Margit Lőrincz, Éva Török, Gyula Gorácz, Ferenc Csitáry
Dátum:1997
Megjegyzések:Primate tissues seem are important for the specificity of IgA type anti-endomysium (EmA),anti-reticulin (ARA) and anti-jejunum (JeA) antibody investigations in gluten-sensitive enteropathy(GSE). Substrate availability and costs for multiple testing are, however, frequent problems.METHODS: Sera of 300 non IgA-deficient GSE patients and 127 controls were tested on frozensections made from appendices surgically removed because of the suspicion of acuteappendicitis, but having normal histology. An indirect immunofluorescent method with IgA-stainingwas used. Conventional assays for EmA, ARA and JeA were carried out on monkey esophagus,human liver/kidney and jejunum respectively. Eighty sera were investigated also on humanumbilical cord tissue. RESULTS: A positive reaction on the appendix (App+) is composed of thestaining of the endomysium, reticulin network and tunica propria fibers, each corresponding to thestandard EmA, ARA and JeA pattern. 295/300 (98.3%) of the GSE patients and 0/127 of thecontrols were App+, without significant differences versus standard autoantibody reactions.Human umbilical cord positivity was observed in 50/54 GSE (92.6%) and in 2/26 (7.6%) controls(p<0.02 vs App+). Absorption studies resulted in fading of all components of App+, irrespective ofwhether esophagus, liver or jejunum had been used. CONCLUSIONS: Use of the human appendixtissue is a suitable and simple alternative to conventional EmA, JeA, ARA determinations. Allthree result in comparable specificity and sensitivity.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
celiac disease
Megjelenés:Medical Science Monitor. - 3 : 3 (1997), p. 295-289. -
További szerzők:Kovács Judit B. Lőrincz Margit Török Éva Gorácz Gyula Csitáry Ferenc
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3.

001-es BibID:BIBFORM044309
Első szerző:Korponay-Szabó Ilma (gyermekgyógyász)
Cím:Prospective significance of antiendomysium antibody positivity in subsequently verified celiac disease / Korponay-Szabó I. R., B. Kovács J., Lörincz M., Gorácz G., Szabados K., Balogh M.
Dátum:1997
Megjegyzések:BACKGROUND: In order to assess their long-term predictability for the diagnosisof celiac disease, antiendomysium antibody results were compared with the outcomeof the Interlaken diagnostic process. METHODS: Prospective gluten challenge was performed in 153 children withpreviously diagnosed flat small-intestine mucosa. In 90 patients (Group A),endomysium antibodies were initially positive, in seven (Group B) they werenegative, and 56 patients (Group C) had no initial serological results. InIgA-deficient persons, IgG antibodies were also assayed, both by theimmunofluorescent method. RESULTS: Histological relapse rates were 100% (90/90), 14.3% (1/7), and 76.8%(43/56), p < 0.001, in Groups A, B, and C, respectively. Each patient withrelapse also exhibited endomysium antibody positivity during the challenge.Patients in whom celiac disease could be finally ruled out remained consistently endomysium-antibody negative. The celiac disease patient in Group B had severesecondary immunoglobulin deficiency at entry, which explained the initialnegativity. Diagnosis based on antiendomysium antibody positivity and flat mucosagave a higher applicability (92.8 vs. 50.3%) and reliability (relapse rate 100vs. 89.6%) than the 1990 European Society of Paediatric Gastroenterology andNutrition (ESPGAN) criteria among these patients. CONCLUSIONS: Endomysium antibody positivity at presentation has been found to be as useful as gluten challenge in the diagnosis of celiac disease, even inpatients under the age of 2 years. Challenge is still advisable in patients with a flat small intestinal mucosa when antiendomysium antibody results are negative or have not been done, as among these patients significantly lower relapse rates were found.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Pediatric Gastroenterology and Nutrition. - 25 : 1 (1997), p. 56-63. -
További szerzők:B. Kovács Judit Lőrincz Margit Gorácz Gyula Szabados Katalin Balogh Márta
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4.

001-es BibID:BIBFORM044308
Első szerző:Korponay-Szabó Ilma (gyermekgyógyász)
Cím:Families with multiple cases of gluten-sensitive enteropathy / Korponay-Szabó I., Kovács J., Lörincz M., Török E., Gorácz G.
Dátum:1998
ISSN:0044-2771
Megjegyzések:Early detection of oligosymptomatic gluten-sensitive enteropathy (GSE) may contribute to the prevention of late complications, such as malignancy. Family members of known GSE patients are at higher risk of being affected. To evaluate the frequency and clinical significance of multiple occurrence, we routinely offered an antiendomysium antibody (EmA)-based noninvasive screening to affected families. Among 997 family members of 396 GSE patients, we identified 89 subjects with EmA positivity and/or severe jejunal villous atrophy. In 83 cases GSE has been verified, four patients refused the biopsy and two subjects are under further observation for latent celiac disease. Prevalence of GSE was 8.5% (80/943) among the first-degree relatives, with significantly higher values in the siblings (13.8%) and offsprings (12.9%) than in the parents (4.2%) of the probands (p < 0.001). In 55 families (13.9% of the families studied) two, in ten families (2.5%) three, in one family four and in one other family six members were affected. Combinations of the clinical presentations of index and screening-detected cases were highly variable, with a high percentage of silent and atypical forms in the relatives. GSE cases presenting both with and without dermatitis herpetiformis occurred in 15 families. Six GSE cases with atypical or mild dermatitis herpetiformis were detected in consequence of the screening. Conclusions: EmA-assisted family screening resulted in the detection of a clinically significant number of additional GSE patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Zeitschrift für Gastroenterologie. - 36 : 7 (1998), p. 553-558. -
További szerzők:Kovács J. (orvos) Lőrincz Margit Török Éva Gorácz Gyula
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5.

001-es BibID:BIBFORM044306
Első szerző:Korponay-Szabó Ilma (gyermekgyógyász)
Cím:High Prevalence of Silent Celiac Disease in Preschool Children Screened with IgA/IgG Antiendomysium Antibodies / Ilma R. Korponay-Szabó, Kovács B. Judit, Antal Czinner, Gyula Gorácz, Adrienn Vámos, Teréz Szabó
Dátum:1999
ISSN:0277-2116
Megjegyzések:BACKGROUND:Because of the different sensitivity and specificity of serologic tests, the search for silent celiac disease is usually performed with the combined or sequential use of several tests. Among these, the IgA-class endomysium antibody test has the highest specificity and positive predictive value, but it may overlook IgA-deficient patients.METHODS:To test a new one-step screening approach, serum samples from 427 apparently healthy, 3- to 6-year-old Hungarian children were investigated for IgA-class and IgG-class endomysium antibodies using monkey esophagus and human jejunum as substrates.RESULTS:Five new cases with flat mucosa were identified by strong endomysium antibody positivity and subsequent jejunal biopsy, yielding a celiac disease prevalence of 1:85. An additional child may have latent celiac disease (slight histologic changes at present). Two of the screening-detected celiac patients exhibited only IgG-class endomysium antibodies due to associated IgA-deficiency. Despite the young age of the screened population, antigliadin antibodies were positive in only three of the five celiac patients.CONCLUSIONS:Prevalence of celiac disease in the study population was much higher than expected on the basis of antigliadin antibody-based studies. The screening system used detected celiac cases in which there was IgA-deficiency and those in which there was not and also those negative for antigliadin antibodies. The findings suggest the importance of the primary testing of autoantibodies in future celiac disease screening policies
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Pediatric Gastroenterology And Nutrition. - 28 : 1 (1999), p. 26-30. -
További szerzők:Kovács Judit B. Czinner Antal Gorácz Gyula Vámos Adrienn Szabó Terézia
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