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001-es BibID:	BIBFORM044310
Első szerző:	Korponay-Szabó Ilma (gyermekgyógyász)
Cím:	The human appendix : a composite substrate for anti-endomysium, anti-reticulin and anti-bowel antibody testing in coeliac disease / Ilma Rita Korponay-Szabó, Judit B. Kovács, Margit Lőrincz, Éva Török, Gyula Gorácz, Ferenc Csitáry
Dátum:	1997
Megjegyzések:	Primate tissues seem are important for the specificity of IgA type anti-endomysium (EmA),anti-reticulin (ARA) and anti-jejunum (JeA) antibody investigations in gluten-sensitive enteropathy(GSE). Substrate availability and costs for multiple testing are, however, frequent problems.METHODS: Sera of 300 non IgA-deficient GSE patients and 127 controls were tested on frozensections made from appendices surgically removed because of the suspicion of acuteappendicitis, but having normal histology. An indirect immunofluorescent method with IgA-stainingwas used. Conventional assays for EmA, ARA and JeA were carried out on monkey esophagus,human liver/kidney and jejunum respectively. Eighty sera were investigated also on humanumbilical cord tissue. RESULTS: A positive reaction on the appendix (App+) is composed of thestaining of the endomysium, reticulin network and tunica propria fibers, each corresponding to thestandard EmA, ARA and JeA pattern. 295/300 (98.3%) of the GSE patients and 0/127 of thecontrols were App+, without significant differences versus standard autoantibody reactions.Human umbilical cord positivity was observed in 50/54 GSE (92.6%) and in 2/26 (7.6%) controls(p<0.02 vs App+). Absorption studies resulted in fading of all components of App+, irrespective ofwhether esophagus, liver or jejunum had been used. CONCLUSIONS: Use of the human appendixtissue is a suitable and simple alternative to conventional EmA, JeA, ARA determinations. Allthree result in comparable specificity and sensitivity.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban celiac disease
Megjelenés:	Medical Science Monitor. - 3 : 3 (1997), p. 295-289. -
További szerzők:	Kovács Judit B. Lőrincz Margit Török Éva Gorácz Gyula Csitáry Ferenc
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM044308
Első szerző:	Korponay-Szabó Ilma (gyermekgyógyász)
Cím:	Families with multiple cases of gluten-sensitive enteropathy / Korponay-Szabó I., Kovács J., Lörincz M., Török E., Gorácz G.
Dátum:	1998
ISSN:	0044-2771
Megjegyzések:	Early detection of oligosymptomatic gluten-sensitive enteropathy (GSE) may contribute to the prevention of late complications, such as malignancy. Family members of known GSE patients are at higher risk of being affected. To evaluate the frequency and clinical significance of multiple occurrence, we routinely offered an antiendomysium antibody (EmA)-based noninvasive screening to affected families. Among 997 family members of 396 GSE patients, we identified 89 subjects with EmA positivity and/or severe jejunal villous atrophy. In 83 cases GSE has been verified, four patients refused the biopsy and two subjects are under further observation for latent celiac disease. Prevalence of GSE was 8.5% (80/943) among the first-degree relatives, with significantly higher values in the siblings (13.8%) and offsprings (12.9%) than in the parents (4.2%) of the probands (p < 0.001). In 55 families (13.9% of the families studied) two, in ten families (2.5%) three, in one family four and in one other family six members were affected. Combinations of the clinical presentations of index and screening-detected cases were highly variable, with a high percentage of silent and atypical forms in the relatives. GSE cases presenting both with and without dermatitis herpetiformis occurred in 15 families. Six GSE cases with atypical or mild dermatitis herpetiformis were detected in consequence of the screening. Conclusions: EmA-assisted family screening resulted in the detection of a clinically significant number of additional GSE patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Zeitschrift für Gastroenterologie. - 36 : 7 (1998), p. 553-558. -
További szerzők:	Kovács J. (orvos) Lőrincz Margit Török Éva Gorácz Gyula
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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