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001-es BibID:BIBFORM072052
Első szerző:Szajewska, H.
Cím:Systematic review with meta-analysis : early infant feeding and coeliac disease - update 2015 / Szajewska H., Shamir R., Chmielewska A., Pieścik-Lech M., Auricchio R., Ivarsson A., Kolacek S., Koletzko S., Korponay-Szabo I., Mearin M. L., Ribes-Koninckx C., Troncone R.
Dátum:2015
ISSN:0269-2813 1365-2036
Megjegyzések:AimTo systematically update evidence on these practices to find out whetherthere is a need to revise current recommendations.MethodsMEDLINE, EMBASE and the Cochrane Library were searched from July2012 (end of last search) to February 2015 for studies of any design thatassessed the effect of gluten consumption and breastfeeding on the developmentof coeliac disease and/or coeliac disease-related autoimmunity.ResultsWe identified 21 publications, including two, new, large, randomised controlledtrials performed in high-risk infants. Exclusive or any breastfeeding,as well as breastfeeding at the time of gluten introduction, did not reducethe risk of developing coeliac disease during childhood. For infants at highrisk of developing coeliac disease, gluten introduction at 4 months of age invery small amounts, or at 6 or 12 months of age, resulted in similar ratesof coeliac disease diagnosis in early childhood. Later gluten introductionwas associated with later development of coeliac specific autoimmunity andcoeliac disease during childhood, but not total risk reduction. Observationalstudies indicate that consumption of a higher amount of gluten at weaningmay increase the risk for coeliac disease development.ConclusionsInfant feeding practices (breastfeeding, time of gluten introduction) have noeffect on the risk of developing coeliac disease during childhood (at least atspecific timeframes evaluated in the included studies), necessitating anupdate of current European recommendations.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
celiac
Megjelenés:Alimentary Pharmacology & Therapeutics 41 : 11 (2015), p. 1038-1054. -
További szerzők:Shamir, Raanan (gyermekgyógyász) Chmielewska, A. Piescik-Lech, M. Auricchio, Renata Ivarsson, Anneli Kolaček, Sanja Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Mearin, Maria Luisa Ribes-Koninckx, Carmen Troncone, Riccardo
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001-es BibID:BIBFORM044249
Első szerző:Szajewska, H.
Cím:Systematic review : early infant feeding and the prevention of coeliac disease / Szajewska, H., Chmielewska, A., Piescik-Lech, M., Ivarsson, A., Kolacek, S., Koletzko, S., Mearin, M. L., Shamir, R., Auricchio, R., Troncone, R., the PREVENTCD Study Group
Dátum:2012
ISSN:0269-2813
Megjegyzések:BACKGROUND: PREVENTCD, Prevent Coeliac Disease, is an international project investigating the hypothesis of possible induction of tolerance to gluten in genetically predisposed children through introducing small quantities of gluten during the period of breastfeeding. AIM: To summarise current knowledge on the possible relationship between early feeding practices and the risk of coeliac disease (CD). METHODS: The Cochrane Library, MEDLINE, and EMBASE databases were searched in May 2011, and the search was updated in January 2012, and again in July 2012. RESULTS: Breastfeeding (BF) and CD: some studies show a protective effect of BF, while others show no effect. No studies have shown a long-term preventive effect. BF at the time of gluten introduction and CD: Results from a meta-analysis of five observational case-control studies suggest that BF at gluten introduction is associated with a lower risk of CD compared with formula feeding. It is unclear whether BF provides a permanent protection or only delays the onset of CD. Timing of gluten introduction: The data suggest that both early (?4 months) and late (?7 months) introduction of gluten may increase the risk of CD. Amount of gluten at weaning (and later) and CD: One incident case-referent study documented that the introduction of gluten in large amounts compared with small or medium amounts increased the risk of CD. CONCLUSIONS: In the absence of clear evidence, in order to decrease the risk of later coeliac disease, it is reasonable to avoid both early (<4 months) and late (?7 months) introduction of gluten, and to introduce gluten while the infant is still being breastfed. Future studies may clarify the remaining uncertainties.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Alimentary Pharmacology & Therapeutics. - 36 : 7 (2012), p. 607-618. -
További szerzők:Chmielewska, A. Piescik-Lech, M. Ivarsson, Anneli Kolaček, Sanja Koletzko, Sibylle Mearin, Maria Luisa Shamir, R. Auricchio, Renata Troncone, Riccardo Korponay-Szabó Ilma (1959-) (gyermekgyógyász) the PREVENTCD Study Group
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DOI
Intézményi repozitóriumban (DEA) tárolt változat
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