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001-es BibID:BIBFORM096513
Első szerző:Auricchio, Renata
Cím:Growth rate of coeliac children is compromised before the onset of the disease / Auricchio Renata, Stellato Pio, Bruzzese Dario, Cielo Donatella, Chiurazzi Alfredo, Galatola Martina, Castillejo Gemma, Crespo Escobar Paula, Gyimesi Judith, Hartman Corina, Kolacek Sanja, Koletzko Sybille, Korponay-Szabo Ilma, Mearin Maria Luisa, Meijer Caroline, Piescik-Lech Malgoscia, Polanco Isabel, Ribes-Koninckx Carmen, Shamir Raanan, Szajewska Hania, Troncone Riccardo, Greco Luigi
Dátum:2020
ISSN:0003-9888
Megjegyzések:Introduction: Growth impairment has often been described in children who develop coeliac disease (CD). Based on data from the multicentre, longitudinal PreventCD study, we analysed the growth patterns of infants at genetic risk of CD, comparing those who developed CD by 6 years of age (CD 'cases', 113 infants) versus those who did not develop CD by 6 years (no CD 'controls', 831 infants). Methods: Weight and length/height were measured using a longitudinal protocol. Raw measurements were standardised, computing z-scores for length/height and weight; a linear mixed model was fitted to the data in order to compare the rate of growth in the two cohorts. Results: Neither cases nor controls had significant growth failure. However, when the mean z-scores for weight and height were analysed, there was a difference between the two groups starting at fourth month of life. When the growth pattern in the first year was analysed longitudinally using mixed models, it emerged that children who develop CD had a significantly lower growth rate in weight z-score (-0.028/month; 95% CI -0.038 to -0.017; p<0.001) and in length/height z-score (-0.018/month; 95% CI -0.031 to -0.005; p=0.008) than those who do not develop CD. When the whole follow-up period was analysed (0-6 years), differences between groups in both weight and length/height z-scores were confirmed. Conclusion: The growth of children at risk of CD rarely fell below 'clinical standards'. However, growth rate was significantly lower in cases than in controls. Our data suggest that peculiar pathways of growth are present in children who develop CD, long before any clinical or serological signs of the disease appear
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
gastroenterology
growth
paediatric practice
coeliac disease
Megjelenés:Archives Of Disease In Childhood. - 105 : 10 (2020), p. 964-968. -
További szerzők:Stellato, Pio Bruzzese, Dario Cielo, Donatella Chiurazzi, Alfredo Galatola, Martina Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Crespo-Escobar, Paula Gyimesi Judit Hartman, Corina Kolaček, Sanja Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Mearin, Maria Luisa Meijer, Caroline R. Pieścik-Lech, Magorzata Polanco, Isabel Ribes-Koninckx, Carmen Shamir, Raanan (gyermekgyógyász) Szajewska, Hania (gyermekgyógyász) Troncone, Riccardo Greco, Luigi
Pályázati támogatás:EU- FP6-2005- FOOD4B- contract no. 03638
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2.

001-es BibID:BIBFORM069474
Első szerző:Crespo-Escobar, Paula
Cím:The role of gluten consumption at an early age in celiac disease development : a further analysis of the prospective PreventCD cohort study / Crespo-Escobar Paula, Mearin Maria Luisa, Hervás David, Auricchio Renata, Castillejo Gemma, Gyimesi Judit, Martinez-Ojinaga Eva, Werkstetter Katharina, Vriezinga Sabine Lisa, Korponay-Szabo Ilma Rita, Polanco Isabel, Troncone Riccardo, Stoopman Els, Kolaček Sanja, Shamir Raanan, Szajewska Hania, Koletzko Sibylle, Ribes-Koninckx Carmen
Dátum:2017
ISSN:0002-9165
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:American Journal of Clinical Nutrition 105 : 4 (2017), p. 890-896. -
További szerzők:Mearin, Maria Luisa Hervás, David Auricchio, Renata Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Gyimesi Judit Martinez-Ojinaga, Eva Werkstetter, Katharina (gyermekgyógyász, gasztroenterológus) Vriezinga, Sabine Lisa (gyermekgyógyász) Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Polanco, Isabel Troncone, Riccardo Stoopman, Els Kolaček, Sanja Shamir, Raanan (gyermekgyógyász) Szajewska, Hania (gyermekgyógyász) Koletzko, Sibylle Ribes-Koninckx, Carmen
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3.

001-es BibID:BIBFORM057433
Első szerző:Korponay-Szabó Ilma (gyermekgyógyász)
Cím:Evolution and HLA-association of the early infantile gliadin antibody response in a high-risk cohort for coeliac disease / Korponay-Szabo I. R., Koletzko S., Gyimesi J., Castillejo G., Mummert E., Bravi E., Ribes-Koninckx C., Polanco I., Shamir R., Kolacek S., Troncone R., Mearin M. L.
Dátum:2013
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:United European Gastroenterology Journal 1 : Suppl. 1 (2013), p. A581. -
További szerzők:Koletzko, Sibylle Gyimesi Judit Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Mummert, Eckart Bravi, Enzo (biológus) Ribes-Koninckx, Carmen Polanco, Isabel Shamir, Raanan (gyermekgyógyász) Kolaček, Sanja Troncone, Riccardo Mearin, Maria Luisa
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4.

001-es BibID:BIBFORM101855
Első szerző:Meijer, Caroline R.
Cím:Prediction models for celiac disease development in children from high-risk families : data from the PreventCD cohort / Meijer Caroline R., Auricchio Renata, Putter Hein, Castillejo Gemma, Crespo Paula, Gyimesi Judit, Hartman Corina, Kolacek Sanja, Koletzko Sibylle, Korponay-Szabo Ilma, Ojinaga Eva Martinez, Polanco Isabel, Ribes-Koninckx Carmen, Shamir Raanan, Szajewska Hania, Troncone Riccardo, Villanacci Vincenzo, Werkstetter Katharina, Mearin M. Luisa
Dátum:2022
ISSN:0016-5085
Megjegyzések:Background and aims: Screening for celiac disease (CD) is recommended in children with affected first-degree relatives (FDR). However, the frequency of screening and at what age remain unknown. Aims: to detect variables influencing the risk of CD-development and develop and validate clinical prediction models to provide individualized screening advice. Methods: Analysis of prospective data from the ten years follow-up of the PreventCD-birth cohort involving 944 genetically predisposed children with CD-FDR. Variables significantly influencing the CD-risk were combined to determine a risk score. Landmark analyses were performed at different ages. Prediction models were created by multivariable Cox proportional hazards regression analyses, backward elimination and Harrell's c-index for discrimination. Validation was done using data from the independent NeoCel cohort. Results: In March 2019, the median follow-up was 8.3 years (22 days-12.0 years); 135/944 children developed CD (mean age 4.3years (1.1-11.4). CD developed significantly more often in girls (p=0.005) and in HLA-DQ2 homozygous individuals (8-year cumulative incidence 35.4% versus maximum of the other HLA-risk groups 18.2% [P<0.001]). The effect of homozygosity DR3-DQ2/DR7-DQ2 on CD-developing was only present in girls (interaction p=0.04). The prediction models showed good fitting in the validation cohort (Cox regression 0.81(0.54)). To calculate a personalized risk of CD-development and provide screening advice, we designed the Prediction application https://hputter.shinyapps.io/preventcd/. Conclusion: Children with CD-FDR develop CD early in life, and their risk depends on gender, age and HLA-DQ:all factors which are important for a sound screening advice. These children should be screened early in life, including HLA-DQ2/8-typing, and if genetically predisposed to CD, should get further personalized screening advice using our Prediction app.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
celiac disease
Megjelenés:Gastroenterology. - 163 : 2 (2022), p. 426-436. -
További szerzők:Auricchio, Renata Putter, Hein Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Crespo-Escobar, Paula Gyimesi Judit Hartman, Corina Kolaček, Sanja Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Ojinaga, Eva Martinez Polanco, Isabel Ribes-Koninckx, Carmen Shamir, Raanan (gyermekgyógyász) Szajewska, Hania (gyermekgyógyász) Troncone, Riccardo Villanacci, Vincenzo Werkstetter, Katharina (gyermekgyógyász, gasztroenterológus) Mearin, Maria Luisa
Pályázati támogatás:OTKA-101788
OTKA
TAMOP 2.2.11/1/KONV-2012-0023
TÁMOP
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5.

001-es BibID:BIBFORM069470
Első szerző:Szajewska, Hania
Cím:Gluten Introduction and the Risk of Coeliac Disease : a Position Paper by the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition / Szajewska Hania, Shamir Raanan, Mearin Luisa, Ribes-Koninckx Carmen, Catassi Carlo, Domellöf Magnus, Fewtrell Mary S., Husby Steffen, Papadopoulou Alexandra, Vandenplas Yvan, Castillejo Gemma, Kolacek Sanja, Koletzko Sibylle, Korponay-Szabó Ilma R., Lionetti Elena, Polanco Isabel, Troncone Riccardo
Dátum:2016
ISSN:0277-2116
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Pediatric Gastroenterology And Nutrition 62 : 3 (2016), p. 507-513. -
További szerzők:Shamir, Raanan (gyermekgyógyász) Mearin, Maria Luisa Ribes-Koninckx, Carmen Catassi, Carlo Domellöf, Magnus Fewtrell, Mary S. Husby, Steffen Papadopoulou, Alexandra Vandenplas, Yvan Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Kolaček, Sanja Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Lionetti, Elena Polanco, Isabel Troncone, Riccardo
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6.

001-es BibID:BIBFORM072052
Első szerző:Szajewska, H.
Cím:Systematic review with meta-analysis : early infant feeding and coeliac disease - update 2015 / Szajewska H., Shamir R., Chmielewska A., Pieścik-Lech M., Auricchio R., Ivarsson A., Kolacek S., Koletzko S., Korponay-Szabo I., Mearin M. L., Ribes-Koninckx C., Troncone R.
Dátum:2015
ISSN:0269-2813 1365-2036
Megjegyzések:AimTo systematically update evidence on these practices to find out whetherthere is a need to revise current recommendations.MethodsMEDLINE, EMBASE and the Cochrane Library were searched from July2012 (end of last search) to February 2015 for studies of any design thatassessed the effect of gluten consumption and breastfeeding on the developmentof coeliac disease and/or coeliac disease-related autoimmunity.ResultsWe identified 21 publications, including two, new, large, randomised controlledtrials performed in high-risk infants. Exclusive or any breastfeeding,as well as breastfeeding at the time of gluten introduction, did not reducethe risk of developing coeliac disease during childhood. For infants at highrisk of developing coeliac disease, gluten introduction at 4 months of age invery small amounts, or at 6 or 12 months of age, resulted in similar ratesof coeliac disease diagnosis in early childhood. Later gluten introductionwas associated with later development of coeliac specific autoimmunity andcoeliac disease during childhood, but not total risk reduction. Observationalstudies indicate that consumption of a higher amount of gluten at weaningmay increase the risk for coeliac disease development.ConclusionsInfant feeding practices (breastfeeding, time of gluten introduction) have noeffect on the risk of developing coeliac disease during childhood (at least atspecific timeframes evaluated in the included studies), necessitating anupdate of current European recommendations.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
celiac
Megjelenés:Alimentary Pharmacology & Therapeutics 41 : 11 (2015), p. 1038-1054. -
További szerzők:Shamir, Raanan (gyermekgyógyász) Chmielewska, A. Piescik-Lech, M. Auricchio, Renata Ivarsson, Anneli Kolaček, Sanja Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Mearin, Maria Luisa Ribes-Koninckx, Carmen Troncone, Riccardo
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7.

001-es BibID:BIBFORM044249
Első szerző:Szajewska, H.
Cím:Systematic review : early infant feeding and the prevention of coeliac disease / Szajewska, H., Chmielewska, A., Piescik-Lech, M., Ivarsson, A., Kolacek, S., Koletzko, S., Mearin, M. L., Shamir, R., Auricchio, R., Troncone, R., the PREVENTCD Study Group
Dátum:2012
ISSN:0269-2813
Megjegyzések:BACKGROUND: PREVENTCD, Prevent Coeliac Disease, is an international project investigating the hypothesis of possible induction of tolerance to gluten in genetically predisposed children through introducing small quantities of gluten during the period of breastfeeding. AIM: To summarise current knowledge on the possible relationship between early feeding practices and the risk of coeliac disease (CD). METHODS: The Cochrane Library, MEDLINE, and EMBASE databases were searched in May 2011, and the search was updated in January 2012, and again in July 2012. RESULTS: Breastfeeding (BF) and CD: some studies show a protective effect of BF, while others show no effect. No studies have shown a long-term preventive effect. BF at the time of gluten introduction and CD: Results from a meta-analysis of five observational case-control studies suggest that BF at gluten introduction is associated with a lower risk of CD compared with formula feeding. It is unclear whether BF provides a permanent protection or only delays the onset of CD. Timing of gluten introduction: The data suggest that both early (?4 months) and late (?7 months) introduction of gluten may increase the risk of CD. Amount of gluten at weaning (and later) and CD: One incident case-referent study documented that the introduction of gluten in large amounts compared with small or medium amounts increased the risk of CD. CONCLUSIONS: In the absence of clear evidence, in order to decrease the risk of later coeliac disease, it is reasonable to avoid both early (<4 months) and late (?7 months) introduction of gluten, and to introduce gluten while the infant is still being breastfed. Future studies may clarify the remaining uncertainties.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Alimentary Pharmacology & Therapeutics. - 36 : 7 (2012), p. 607-618. -
További szerzők:Chmielewska, A. Piescik-Lech, M. Ivarsson, Anneli Kolaček, Sanja Koletzko, Sibylle Mearin, Maria Luisa Shamir, R. Auricchio, Renata Troncone, Riccardo Korponay-Szabó Ilma (1959-) (gyermekgyógyász) the PREVENTCD Study Group
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8.

001-es BibID:BIBFORM056540
Első szerző:Vriezinga, Sabine Lisa
Cím:Randomized feeding intervention in infants at high risk for celiac disease / S. L. Vriezinga, R. Auricchio, E. Bravi, G. Castillejo, A. Chmielewska, P. Crespo Escobar, S. Kolaček, S. Koletzko, I. R. Korponay-Szabo, E. Mummert, I. Polanco, H. Putter, C. Ribes-Koninckx, R. Shamir, H. Szajewska, K. Werkstetter, L. Greco, J. Gyimesi, C. Hartman, C. Hogen Esch, E. Hopman, A. Ivarsson, T. Koltai, F. Koning, E. Martinez-Ojinaga, C. te Marvelde, A. Mocic Pavic, J. Romanos, E. Stoopman, V. Villanacci, C. Wijmenga, R. Troncone, M. L. Mearin
Dátum:2014
ISSN:0028-4793
Megjegyzések:BACKGROUND A window of opportunity has been suggested for reducing the risk of celiac disease by introducing gluten to infants at 4 to 6 months of age. METHODS We performed a multicenter, randomized, double-blind, placebo-controlled dietaryintervention study involving 944 children who were positive for HLA-DQ2 or HLADQ8 and had at least one first-degree relative with celiac disease. From 16 to 24 weeks of age, 475 participants received 100 mg of immunologically active gluten daily, and 469 received placebo. Anti-transglutaminase type 2 and antigliadin antibodies were periodically measured. The primary outcome was the frequency of biopsy-confirmed celiac disease at 3 years of age. RESULTS Celiac disease was confirmed by means of biopsies in 77 children. To avoid underestimation of the frequency of celiac disease, 3 additional children who received a diagnosis of celiac disease according to the 2012 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition diagnostic criteria (without having undergone biopsies) were included in the analyses (80 children; median age, 2.8 years; 59% were girls). The cumulative incidence of celiac disease among patients 3 years of age was 5.2% (95% confidence interval [CI], 3.6 to 6.8), with similar rates in the gluten group and the placebo group (5.9% [95% CI, 3.7 to 8.1] and 4.5% [95% CI, 2.5 to 6.5], respectively; hazard ratio in the gluten group, 1.23; 95% CI, 0.79 to 1.91). Rates of elevated levels of anti-transglutaminase type 2 and antigliadin antibodies were also similar in the two study groups (7.0% [95% CI, 4.7 to 9.4] in the gluten group and 5.7% [95% CI, 3.5 to 7.9] in the placebo group; hazard ratio, 1.14; 95% CI, 0.76 to 1.73). Breast-feeding, regardless of whether it was exclusive or whether it was ongoing during gluten introduction, did not significantly influence the development of celiac disease or the effect of the intervention. CONCLUSIONS As compared with placebo, the introduction of small quantities of gluten at 16 to 24 weeks of age did not reduce the risk of celiac disease by 3 years of age in this group of high-risk children. (Funded by the European Commission and others; PreventCD Current Controlled Trials number, ISRCTN74582487.)
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:New England Journal Of Medicine 371 : 14 (2014), p. 1304-1315. -
További szerzők:Auricchio, Renata Bravi, Enzo (biológus) Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Chmielewska, Anna Crespo-Escobar, Paula Kolaček, Sanja Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Mummert, Eckart Polanco, Isabel Putter, Hein Ribes-Koninckx, Carmen Shamir, Raanan (gyermekgyógyász) Szajewska, Hania (gyermekgyógyász) Werkstetter, Katharina (gyermekgyógyász, gasztroenterológus) Greco, Luigi Gyimesi Judit Hartman, Corina Hogen Esch, Caroline Hopman, Erica Ivarsson, Anneli Koltai Tünde Koning, Frits Martinez-Ojinaga, Eva Marvelde, Chantal te Pavic, Ana Romanos, Jihane Stoopman, Els Villanacci, Vincenzo Wijmenga, Cisca Troncone, Riccardo Mearin, Maria Luisa
Pályázati támogatás:TÁMOP-2.2.11/1/KONV-2012-0023
TÁMOP
101788
OTKA
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