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001-es BibID:	BIBFORM072048
Első szerző:	Borrelli, M.
Cím:	Intestinal anti-transglutaminase 2 immunoglobulin A deposits in children at risk for coeliac disease (CD) : data from the PreventCD study / Borrelli M., Maglio M., Korponay-Szabó I. R., Vass V., Mearin M. L., Meijer C., Niv-Drori H., Ribes-Koninckx C., Roca M., Shamir R., Troncone R., Auricchio R.
Dátum:	2018
ISSN:	0009-9104
Megjegyzések:	In coeliac disease (CD), anti-tissue transglutaminase 2 immunoglobulin(Ig)A antibodies (anti-TG2) are produced and deposited in the intestine.PreventCD (www.preventcd.com) is a European multi-centre study, whichinvestigates the influence of infant nutrition and that of genetic,immunological and other environmental factors on the risk of developingCD. The aim of the current study was to evaluate the appearance ofintestinal anti-TG2 deposits in very early intestinal biopsies from at-riskinfants and their predictive value for villous atrophy. Sixty-five small bowelbiopsies, performed in 62 children, were investigated for the presenceof intestinal anti-TG2 extracellular IgA deposits by using doubleimmunofluorescence. The biopsies were performed in the presence ofelevated serum levels of CD-associated antibodies and/or symptomssuggesting disease. Deposits of anti-TG2 IgA were present in 53 of 53 CDpatients and three of three potential CD patients. In potential CD patients,mucosal deposits showed a patchy distribution characterized by some areascompletely negative, whereas active CD patients had uniformly present andevident mucosal deposits. Only one of six patients without CD (negative forserum anti-TG2 and with normal mucosa) had intestinal deposits with apatchy distribution and a weak staining. Two of the 53 CD patients receiveda definitive diagnosis of CD after a second or third biopsy; mucosal depositsof anti-TG2 IgA were evaluated in all samples. Before developing villous atrophy, both patients had anti-TG2 deposits in normal mucosalarchitecture, antibodies in one patient being absent in serum. We demonstrated that in CD the intestinal deposits of anti-TG2 are a constant presence and appear very early in the natural history of disease.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban celiac
Megjelenés:	Clinical And Experimental Immunology. - 191 : 3 (2018), p. 311-317. -
További szerzők:	Maglio, M. Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Vass V. Mearin, Maria Luisa Meijer, Caroline R. Niv-Drori, H. Ribes-Koninckx, Carmen Roca, María Shamir, R. Troncone, Riccardo Auricchio, Renata
Pályázati támogatás:	GINOP-2.3.2-15-2016-00015 GINOP NKFI-120392 NKFI OTKA-101788 OTKA
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM044266
Első szerző:	Husby, Steffen
Cím:	European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease / Husby, S., Koletzko, S., Korponay-Szabó, I. R., Mearin, M. L., Phillips, A., Shamir, R., Troncone, R., Giersiepen, K., Branski, D., Catassi, C., Lelgeman, M., Mäki, M., Ribes-Koninckx, C., Ventura, A., Zimmer, K. P., the ESPGHAN Working Group on Coeliac Disease Diagnosis, the ESPGHAN Gastroenterology Committee
Dátum:	2012
ISSN:	0277-2116
Megjegyzések:	OBJECTIVE: Diagnostic criteria for coeliac disease (CD) from the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) were published in 1990. Since then, the autoantigen in CD, tissue transglutaminase, has been identified; the perception of CD has changed from that of a rather uncommon enteropathy to a common multiorgan disease strongly dependent on the haplotypes human leukocyte antigen (HLA)-DQ2 and HLA-DQ8; and CD-specific antibody tests have improved.METHODS:A panel of 17 experts defined CD and developed new diagnostic criteria based on the Delphi process. Two groups of patients were defined with different diagnostic approaches to diagnose CD: children with symptoms suggestive of CD (group 1) and asymptomatic children at increased risk for CD (group 2). The 2004 National Institutes of Health/Agency for Healthcare Research and Quality report and a systematic literature search on antibody tests for CD in paediatric patients covering the years 2004 to 2009 was the basis for the evidence-based recommendations on CD-specific antibody testing.RESULTS:In group 1, the diagnosis of CD is based on symptoms, positive serology, and histology that is consistent with CD. If immunoglobulin A anti-tissue transglutaminase type 2 antibody titers are high (>10 times the upper limit of normal), then the option is to diagnose CD without duodenal biopsies by applying a strict protocol with further laboratory tests. In group 2, the diagnosis of CD is based on positive serology and histology. HLA-DQ2 and HLA-DQ8 testing is valuable because CD is unlikely if both haplotypes are negative.CONCLUSIONS:The aim of the new guidelines was to achieve a high diagnostic accuracy and to reduce the burden for patients and their families. The performance of these guidelines in clinical practice should be evaluated prospectively.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban celiac disease
Megjelenés:	Journal Of Pediatric Gastroenterology And Nutrition 54 : 1 (2012), p. 136-160. -
További szerzők:	Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Mearin, Maria Luisa Phillips, A. Shamir, R. Troncone, Riccardo Giersiepen, Klaus Branski, D. Catassi, Carlo Lelgemann, Monika Mäki, Markku Ribes-Koninckx, Carmen Ventura, Alessandro Zimmer, Klaus-Peter the ESPGHAN Working Group on Coeliac Disease Diagnosis the ESPGHAN Gastroenterology Committee
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM044265
Első szerző:	Ribes-Koninckx, Carmen
Cím:	Coeliac Disease Diagnosis : ESPGHAN 1990 Criteria or Need For a Change? Results of a Questionnaire / C. Ribes-Koninckx, M. L. Mearin, I. R. Korponay-Szabó, R. Shamir, S. Husby, A. Ventura, D. Branski, C. Catassi, S. Koletzko, M. Mäki, R. Troncone, K. P. Zimmer, the ESPGHAN Working Group on Coeliac Disease Diagnosis
Dátum:	2012
ISSN:	0277-2116
Megjegyzések:	INTRODUCTION:: A revision of criteria for diagnosing celiac disease (CD) is currently being conducted by ESPGHAN. In parallel, we have performed a survey aimed to evaluate current practices for CD among pediatric gastroenterologists (PG) and to learn their views on the need for modification of current criteria for CD diagnosis. METHODS:: Questionnaires were distributed to experienced PG (ESPGHAN members) via internet. RESULTS:: Overall, 95 valid questionnaires were available for analysis, pertaining to 28 different countries, with the majority of responders treating CD patients for more than 15 years. Only about 12% of the responders comply with current criteria, noncompliance being related mainly to the challenge policy.About 90 % request a revision and modification of the current criteria. 44% want to omit the SBB in symptomatic children with positive anti-tissue Transglutaminase (tTG) IgA or endomysial (EMA) IgA antibodies, specially if they are DQ2/DQ8 positive. For silent cases detected by screening with convincingly positive tTG IgA or EMA IgA, about 30% consider that no small bowel biopsy (SBB) should be required in selected cases. Adding HLA typing in the diagnostic work up was asked for by 42% of the responders. As for gluten challenge a new policy is advocated restricting its obligation to cases whenever the diagnosis is doubtful or unclear. CONCLUSIONS:: Based on these opinions, revision of the ESPGHAN criteria for diagnosing CD is urgently needed.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban celiac disease
Megjelenés:	Journal of Pediatric Gastroenterology and Nutrition. - 54 : 1 (2012), p. 15-19. -
További szerzők:	Mearin, Maria Luisa Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Shamir, R. Husby, Steffen Ventura, Alessandro Branski, D. Catassi, Carlo Koletzko, Sibylle Mäki, Markku Troncone, Riccardo Zimmer, Klaus-Peter the ESPGHAN Working Group on Coeliac Disease Diagnosis
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM044249
Első szerző:	Szajewska, H.
Cím:	Systematic review : early infant feeding and the prevention of coeliac disease / Szajewska, H., Chmielewska, A., Piescik-Lech, M., Ivarsson, A., Kolacek, S., Koletzko, S., Mearin, M. L., Shamir, R., Auricchio, R., Troncone, R., the PREVENTCD Study Group
Dátum:	2012
ISSN:	0269-2813
Megjegyzések:	BACKGROUND: PREVENTCD, Prevent Coeliac Disease, is an international project investigating the hypothesis of possible induction of tolerance to gluten in genetically predisposed children through introducing small quantities of gluten during the period of breastfeeding. AIM: To summarise current knowledge on the possible relationship between early feeding practices and the risk of coeliac disease (CD). METHODS: The Cochrane Library, MEDLINE, and EMBASE databases were searched in May 2011, and the search was updated in January 2012, and again in July 2012. RESULTS: Breastfeeding (BF) and CD: some studies show a protective effect of BF, while others show no effect. No studies have shown a long-term preventive effect. BF at the time of gluten introduction and CD: Results from a meta-analysis of five observational case-control studies suggest that BF at gluten introduction is associated with a lower risk of CD compared with formula feeding. It is unclear whether BF provides a permanent protection or only delays the onset of CD. Timing of gluten introduction: The data suggest that both early (?4 months) and late (?7 months) introduction of gluten may increase the risk of CD. Amount of gluten at weaning (and later) and CD: One incident case-referent study documented that the introduction of gluten in large amounts compared with small or medium amounts increased the risk of CD. CONCLUSIONS: In the absence of clear evidence, in order to decrease the risk of later coeliac disease, it is reasonable to avoid both early (<4 months) and late (?7 months) introduction of gluten, and to introduce gluten while the infant is still being breastfed. Future studies may clarify the remaining uncertainties.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Alimentary Pharmacology & Therapeutics. - 36 : 7 (2012), p. 607-618. -
További szerzők:	Chmielewska, A. Piescik-Lech, M. Ivarsson, Anneli Kolaček, Sanja Koletzko, Sibylle Mearin, Maria Luisa Shamir, R. Auricchio, Renata Troncone, Riccardo Korponay-Szabó Ilma (1959-) (gyermekgyógyász) the PREVENTCD Study Group
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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