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001-es BibID:BIBFORM044267
Első szerző:Giersiepen, Klaus
Cím:Accuracy of Diagnostic Antibody Tests for Coeliac Disease in Children / Giersiepen Klaus, Lelgemann Monika, Stuhldreher Nina, Ronfani Luca, Husby Steffen, Koletzko Sibylle, Korponay-Szabó Ilma R., the ESPGHAN Working Group on Coeliac Disease Diagnosis
Dátum:2012
ISSN:0277-2116
Megjegyzések:OBJECTIVE: The aim of this study was to summarise the evidence from 2004 toSeptember 2009 on the performance of laboratory-based serological and point ofcare (POC) tests for diagnosing coeliac disease (CD) in children using histology as reference standard.PATIENTS AND METHODS: We searched MEDLINE and EMBASE for studies reporting onchildren for tests based on IgA and IgG anti-gliadin (AGA), endomysial (EmA),anti-transglutaminase-2 (TG2), and anti-deamidated gliadin peptides (DGP)antibodies or POC tests. For inclusion, histological analysis of duodenalbiopsies and sensitivity and specificity for index tests had to be reported. Datawere pooled and summary measures calculated for sensitivity, specificity,positive and negative likelihood ratios ("LR+", "LR-"), and diagnostic oddsratios (DOR). In case of elevated statistical heterogeneity, studies reaching 90%sensitivity or specificity were reported.RESULTS: A total of 2510 articles were reviewed; 16 entered meta-analysis,reporting on 3110 patients (1876 with CD, 1234 without CD). For IgA-EmA,sensitivity was ?90% in 7/11 studies and pooled specificity 98.2%. ForIgA-anti-TG2, 11/15 studies yielded sensitivities ?90% and 13/15 specificities?90%. For IgA-DGP, sensitivity ranged between 80.7% and 95.1% (specificity86.3%-93.1%); for IgG-DGP between 80.1% and 98.6% (specificity 86.0-96.9%).IgA-EmA had the highest pooled DOR (554) and LR+ (31.8) for a laboratory test,followed by IgA-anti-TG2, IgG-DGP, IgA-DGP and IgA-AGA. POC tests showed a pooledsensitivity of 96.4% for IgA-TG2 (specificity 97.7%).CONCLUSIONS: IgA-EmA and IgA-anti-TG2 tests appear highly accurate to diagnoseCD. IgG-anti-DGP tests may help in excluding CD. IgA-AGA and IgA-DGP tests showinferior accuracy. POC tests may achieve high accuracy in the hands ofexperienced readers, but IgA-anti-TG2/EmA were superior.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Pediatric Gastroenterology And Nutrition. - 54 : 2 (2012), p. 229-241. -
További szerzők:Lelgemann, Monika Stuhldreher, Nina Ronfani, Luca Husby, Steffen Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) the ESPGHAN Working Group on Coeliac Disease Diagnosis
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2.

001-es BibID:BIBFORM091976
Első szerző:Husby, Steffen
Cím:European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease 2020 / Steffen Husby, Sibylle Koletzko, Ilma Korponay-Szabó, Kalle Kurppa, Maria Luisa Mearin, Carmen Ribes-Koninckx, Raanan Shamir, Riccardo Troncone, Renata Auricchio, Gemma Castillejo, Robin Christensen, Jernej Dolinsek, Peter Gillett, Asbjørn Hróbjartsson, Tunde Koltai, Markku Maki, Sabrina Mai Nielsen, Alina Popp, Ketil Størdal, Katharina Werkstetter, Margreet Wessels
Dátum:2020
ISSN:0277-2116
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal of pediatric gastroenterology and nutrition. - 70 : 1 (2020), p. 141-156. -
További szerzők:Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Kurppa, Kalle Mearin, Maria Luisa Ribes-Koninckx, Carmen Shamir, Raanan (gyermekgyógyász) Troncone, Riccardo Auricchio, Renata Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Christensen, Robin Dolinśek, Jernej Gillett, Peter Hróbjartsson, Asbjørn Koltai Tünde Mäki, Markku Nielsen, Sabrina Mai Popp, Alina Størdal, Ketil Werkstetter, Katharina (gyermekgyógyász, gasztroenterológus) Wessels, Margreet
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3.

001-es BibID:BIBFORM044266
Első szerző:Husby, Steffen
Cím:European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease / Husby, S., Koletzko, S., Korponay-Szabó, I. R., Mearin, M. L., Phillips, A., Shamir, R., Troncone, R., Giersiepen, K., Branski, D., Catassi, C., Lelgeman, M., Mäki, M., Ribes-Koninckx, C., Ventura, A., Zimmer, K. P., the ESPGHAN Working Group on Coeliac Disease Diagnosis, the ESPGHAN Gastroenterology Committee
Dátum:2012
ISSN:0277-2116
Megjegyzések:OBJECTIVE: Diagnostic criteria for coeliac disease (CD) from the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) were published in 1990. Since then, the autoantigen in CD, tissue transglutaminase, has been identified; the perception of CD has changed from that of a rather uncommon enteropathy to a common multiorgan disease strongly dependent on the haplotypes human leukocyte antigen (HLA)-DQ2 and HLA-DQ8; and CD-specific antibody tests have improved.METHODS:A panel of 17 experts defined CD and developed new diagnostic criteria based on the Delphi process. Two groups of patients were defined with different diagnostic approaches to diagnose CD: children with symptoms suggestive of CD (group 1) and asymptomatic children at increased risk for CD (group 2). The 2004 National Institutes of Health/Agency for Healthcare Research and Quality report and a systematic literature search on antibody tests for CD in paediatric patients covering the years 2004 to 2009 was the basis for the evidence-based recommendations on CD-specific antibody testing.RESULTS:In group 1, the diagnosis of CD is based on symptoms, positive serology, and histology that is consistent with CD. If immunoglobulin A anti-tissue transglutaminase type 2 antibody titers are high (>10 times the upper limit of normal), then the option is to diagnose CD without duodenal biopsies by applying a strict protocol with further laboratory tests. In group 2, the diagnosis of CD is based on positive serology and histology. HLA-DQ2 and HLA-DQ8 testing is valuable because CD is unlikely if both haplotypes are negative.CONCLUSIONS:The aim of the new guidelines was to achieve a high diagnostic accuracy and to reduce the burden for patients and their families. The performance of these guidelines in clinical practice should be evaluated prospectively.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
celiac disease
Megjelenés:Journal Of Pediatric Gastroenterology And Nutrition 54 : 1 (2012), p. 136-160. -
További szerzők:Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Mearin, Maria Luisa Phillips, A. Shamir, R. Troncone, Riccardo Giersiepen, Klaus Branski, D. Catassi, Carlo Lelgemann, Monika Mäki, Markku Ribes-Koninckx, Carmen Ventura, Alessandro Zimmer, Klaus-Peter the ESPGHAN Working Group on Coeliac Disease Diagnosis the ESPGHAN Gastroenterology Committee
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4.

001-es BibID:BIBFORM103510
035-os BibID:(Wos)000841921200031 (Scopus)85136851907
Első szerző:Mearin, Maria Luisa
Cím:ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease / Mearin Maria Luisa, Agardh Daniel, Antunes Henedina, Al-toma Abdul, Auricchio Renata, Castillejo Gemma, Catassi Carlo, Ciacci Carolina, Discepolo Valentina, Dolinsek Jernej, Donat Ester, Gillett Peter, Guandalini Steffano, Husby Steffen, Koletzko Sibylle, Koltai Tunde, Korponay-Szabó Ilma Rita, Kurppa Kalle, Lionetti Elena, Marild Karl, Martinez Ojinaga Eva, Meijer Caroline, Monachesi Chiara, Polanco Isabel, Popp Alina, Roca Maria, Rodriguez-Herrera Alfonso, Shamir Raanan, Størdal Ketil, Troncone Riccardo, Valitutti Francesco, Vreugdenhil Anita, Wessels Margreet, Whiting Penny, ESPGHAN Special Interest Group on Celiac Disease
Dátum:2022
ISSN:0277-2116
Megjegyzések:Objectives: To gather the current evidence and to offer recommendations for follow-up and management. Methods: The Special Interest Group on Celiac Diseases of the European Society of Paediatric Gastroenterology Hepatology and Nutrition formulated ten questions considered to be essential for follow-up care. A literature search (January 2010-March 2020) was performed in PubMed or Medline. Relevant publications were identified and potentially eligible studies were assessed. Statements and recommendations were developed and discussed by all coauthors. Recommendations were voted upon: joint agreement was set as at least 85%. Results: Publications (n = 2775) were identified and 164 were included. Using evidence or expert opinion, 37 recommendations were formulated on: The need to perform follow-up, its frequency and what should be assessed, how to assess adherence to the gluten-free diet, when to expect catch-up growth, how to treat anemia, how to approach persistent high serum levels of antibodies against tissue-transglutaminase, the indication to perform biopsies, assessment of quality of life, management of children with unclear diagnosis for which a gluten-challenge is indicated, children with associated type 1 diabetes or IgA deficiency, cases of potential celiac disease, which professionals should perform follow-up, how to improve the communication to patients and their parents/caregivers and transition from pediatric to adult health care. Conclusions: We offer recommendations to improve follow-up of children and adolescents with celiac disease and highlight gaps that should be investigated to further improve management.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal Of Pediatric Gastroenterology And Nutrition. - 75 : 3 (2022), p. 369-386. -
További szerzők:Agardh, Daniel Antunes, Henedina Al-toma, Abdul Auricchio, Renata Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Catassi, Carlo Ciacci, Carolina Discepolo, Valentina Dolinśek, Jernej Donat, Ester Gillett, Peter Guandalini, Steffano Husby, Steffen Koletzko, Sibylle Koltai Tünde Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Kurppa, Kalle Lionetti, Elena Marild, Karl Martinez Ojinaga, Eva Meijer, Caroline R. Monachesi, Chiara Polanco, Isabel Popp, Alina Roca, María Rodriguez-Herrera, Alfonso Shamir, Raanan (gyermekgyógyász) Størdal, Ketil Troncone, Riccardo Valitutti, Francesco Vreugdenhil, Anita C. E. Wessels, Margreet Whiting, Penny ESPGHAN Special Interest Group on Celiac Disease
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5.

001-es BibID:BIBFORM044265
Első szerző:Ribes-Koninckx, Carmen
Cím:Coeliac Disease Diagnosis : ESPGHAN 1990 Criteria or Need For a Change? Results of a Questionnaire / C. Ribes-Koninckx, M. L. Mearin, I. R. Korponay-Szabó, R. Shamir, S. Husby, A. Ventura, D. Branski, C. Catassi, S. Koletzko, M. Mäki, R. Troncone, K. P. Zimmer, the ESPGHAN Working Group on Coeliac Disease Diagnosis
Dátum:2012
ISSN:0277-2116
Megjegyzések:INTRODUCTION:: A revision of criteria for diagnosing celiac disease (CD) is currently being conducted by ESPGHAN. In parallel, we have performed a survey aimed to evaluate current practices for CD among pediatric gastroenterologists (PG) and to learn their views on the need for modification of current criteria for CD diagnosis. METHODS:: Questionnaires were distributed to experienced PG (ESPGHAN members) via internet. RESULTS:: Overall, 95 valid questionnaires were available for analysis, pertaining to 28 different countries, with the majority of responders treating CD patients for more than 15 years. Only about 12% of the responders comply with current criteria, noncompliance being related mainly to the challenge policy.About 90 % request a revision and modification of the current criteria. 44% want to omit the SBB in symptomatic children with positive anti-tissue Transglutaminase (tTG) IgA or endomysial (EMA) IgA antibodies, specially if they are DQ2/DQ8 positive. For silent cases detected by screening with convincingly positive tTG IgA or EMA IgA, about 30% consider that no small bowel biopsy (SBB) should be required in selected cases. Adding HLA typing in the diagnostic work up was asked for by 42% of the responders. As for gluten challenge a new policy is advocated restricting its obligation to cases whenever the diagnosis is doubtful or unclear. CONCLUSIONS:: Based on these opinions, revision of the ESPGHAN criteria for diagnosing CD is urgently needed.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
celiac disease
Megjelenés:Journal of Pediatric Gastroenterology and Nutrition. - 54 : 1 (2012), p. 15-19. -
További szerzők:Mearin, Maria Luisa Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Shamir, R. Husby, Steffen Ventura, Alessandro Branski, D. Catassi, Carlo Koletzko, Sibylle Mäki, Markku Troncone, Riccardo Zimmer, Klaus-Peter the ESPGHAN Working Group on Coeliac Disease Diagnosis
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6.

001-es BibID:BIBFORM069470
Első szerző:Szajewska, Hania
Cím:Gluten Introduction and the Risk of Coeliac Disease : a Position Paper by the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition / Szajewska Hania, Shamir Raanan, Mearin Luisa, Ribes-Koninckx Carmen, Catassi Carlo, Domellöf Magnus, Fewtrell Mary S., Husby Steffen, Papadopoulou Alexandra, Vandenplas Yvan, Castillejo Gemma, Kolacek Sanja, Koletzko Sibylle, Korponay-Szabó Ilma R., Lionetti Elena, Polanco Isabel, Troncone Riccardo
Dátum:2016
ISSN:0277-2116
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Pediatric Gastroenterology And Nutrition 62 : 3 (2016), p. 507-513. -
További szerzők:Shamir, Raanan (gyermekgyógyász) Mearin, Maria Luisa Ribes-Koninckx, Carmen Catassi, Carlo Domellöf, Magnus Fewtrell, Mary S. Husby, Steffen Papadopoulou, Alexandra Vandenplas, Yvan Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Kolaček, Sanja Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Lionetti, Elena Polanco, Isabel Troncone, Riccardo
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7.

001-es BibID:BIBFORM072050
Első szerző:Werkstetter, Katharina
Cím:Accuracy in Diagnosis of Celiac Disease Without Biopsies in Clinical Practice / Werkstetter Katharina J., Korponay-Szabó Ilma Rita, Popp Alina, Villanacci Vincenzo, Salemme Marianna, Heilig Gabriele, Lillevang Sren Thue, Mearin Maria Luisa, Ribes-Koninckx Carmen, Thomas Adrian, Troncone Riccardo, Filipiak Birgit, Mäki Markku, Gyimesi Judit, Najafi Mehri, Dolinsek Jernej, Dydensborg Sander Stine, Auricchio Renata, Papadopoulou Alexandra, Vécsei Andreas, Szitanyi Peter, Donat Ester, Nenna Rafaella, Alliet Philippe, Penagini Francesca, Garnier-Lengliné Hélene, Castillejo Gemma, Kurppa Kalle, Shamir Raanan, Hauer Almuthe Christine, Smets Francoise, Corujeira Susana, van Winckel Myriam, Buderus Stefan, Chong Sonny, Husby Steffen, Koletzko Sibylle, ProCeDE study group
Dátum:2017
ISSN:0016-5085
Megjegyzések:BACKGROUND & AIMS:The guidelines of the European Society of Pediatric Gastroenterology, Hepatology, and Nutrition allow for diagnosis of celiac disease without biopsies in children with symptoms and levels of immunoglobulin A against tissue-transglutaminase (TGA-IgA) 10-fold or more the upper limit of normal (ULN), confirmed by detection of endomysium antibodies (EMA) and positivity for HLA-DQ2/DQ8. We performed a large, international prospective study to validate this approach.METHODS:We collected data from consecutive pediatric patients (18 years or younger) on a gluten-containing diet who tested positive for TGA-IgA from November 2011 through May 2014, seen at 33 pediatric gastroenterology units in 21 countries. Local centers recorded symptoms; measurements of total IgA, TGA, and EMA; and histopathology findings from duodenal biopsies. Children were considered to have malabsorption if they had chronic diarrhea, weight loss (or insufficient gain), growth failure, or anemia. We directly compared central findings from 16 antibody tests (8 for TGA-IgA, 1 for TGA-IgG, 6 for IgG against deamidated gliadin peptides, and 1 for EMA, from 5 different manufacturers), 2 HLA-DQ2/DQ8 tests from 2 manufacturers, and histopathology findings from the reference pathologist. Final diagnoses were based on local and central results. If all local and central results were concordant for celiac disease, cases were classified as proven celiac disease. Patients with only a low level of TGA-IgA (threefold or less the ULN) but no other results indicating celiac disease were classified as no celiac disease. Central histo-morphometry analyses were performed on all other biopsies and cases were carefully reviewed in a blinded manner. Inconclusive cases were regarded as not having celiac disease for calculation of diagnostic accuracy. The primary aim was to determine whether the nonbiopsy approach identifies children with celiac disease with a positive predictive value (PPV) above 99% in clinical practice. Secondary aims included comparing performance of different serological tests and to determine whether the suggested criteria can be simplified.RESULTS:Of 803 children recruited for the study, 96 were excluded due to incomplete data, low level of IgA, or poor-quality biopsies. In the remaining 707 children (65.1% girls; median age, 6.2 years), 645 were diagnosed with celiac disease, 46 were found not to have celiac disease, and 16 had inconclusive results. Findings from local laboratories of TGA-IgA 10-fold or more the ULN, a positive result from the test for EMA, and any symptom identified children with celiac disease (n = 399) with a PPV of 99.75 (95% confidence interval [CI], 98.61-99.99); the PPV was 100.00 (95% CI, 98.68-100.00) when only malabsorption symptoms were used instead of any symptom (n = 278). Inclusion of HLA analyses did not increase accuracy. Findings from central laboratories differed greatly for patients with lower levels of antibodies, but when levels of TGA-IgA were 10-fold or more the ULN, PPVs ranged from 99.63 (95% CI, 98.67-99.96) to 100.00 (95% CI, 99.23-100.00).CONCLUSIONS:Children can be accurately diagnosed with celiac disease without biopsy analysis. Diagnosis based on level of TGA-IgA 10-fold or more the ULN, a positive result from the EMA tests in a second blood sample, and the presence of at least 1 symptom could avoid risks and costs of endoscopy for more than half the children with celiac disease worldwide. HLA analysis is not required for accurate diagnosis. Clinical Trial Registration no: DRKS00003555.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
celiac
Megjelenés:Gastroenterology 153 : 4 (2017), p. 924-935. -
További szerzők:Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Popp, Alina Villanacci, Vincenzo Salemme Marianna Heilig, Gabriele Lillevang, Sren Thue Mearin, Maria Luisa Ribes-Koninckx, Carmen Thomas, Adrian Troncone, Riccardo Filipiak, Birgit Mäki, Markku Gyimesi Judit Najafi, Mehri Dolinśek, Jernej Dydensborg Sander, Stine Auricchio, Renata Papadopoulou, Alexandra Vécsei Andreas Szitanyi Péter Donat, Ester Nenna, Rafaella Alliet, Philippe Penagini, Francesca Garnier-Lengliné, Hélene Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Kurppa, Kalle Shamir, Raanan (gyermekgyógyász) Hauer, Almuthe Christine Smets, Francoise Corujeira, Susana van Winckel, Myriam Buderus, Stefan Chong, Sonny Husby, Steffen Koletzko, Sibylle ProCeDE study group
Pályázati támogatás:OTKA-101788
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