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1.

001-es BibID:BIBFORM096513
Első szerző:Auricchio, Renata
Cím:Growth rate of coeliac children is compromised before the onset of the disease / Auricchio Renata, Stellato Pio, Bruzzese Dario, Cielo Donatella, Chiurazzi Alfredo, Galatola Martina, Castillejo Gemma, Crespo Escobar Paula, Gyimesi Judith, Hartman Corina, Kolacek Sanja, Koletzko Sybille, Korponay-Szabo Ilma, Mearin Maria Luisa, Meijer Caroline, Piescik-Lech Malgoscia, Polanco Isabel, Ribes-Koninckx Carmen, Shamir Raanan, Szajewska Hania, Troncone Riccardo, Greco Luigi
Dátum:2020
ISSN:0003-9888
Megjegyzések:Introduction: Growth impairment has often been described in children who develop coeliac disease (CD). Based on data from the multicentre, longitudinal PreventCD study, we analysed the growth patterns of infants at genetic risk of CD, comparing those who developed CD by 6 years of age (CD 'cases', 113 infants) versus those who did not develop CD by 6 years (no CD 'controls', 831 infants). Methods: Weight and length/height were measured using a longitudinal protocol. Raw measurements were standardised, computing z-scores for length/height and weight; a linear mixed model was fitted to the data in order to compare the rate of growth in the two cohorts. Results: Neither cases nor controls had significant growth failure. However, when the mean z-scores for weight and height were analysed, there was a difference between the two groups starting at fourth month of life. When the growth pattern in the first year was analysed longitudinally using mixed models, it emerged that children who develop CD had a significantly lower growth rate in weight z-score (-0.028/month; 95% CI -0.038 to -0.017; p<0.001) and in length/height z-score (-0.018/month; 95% CI -0.031 to -0.005; p=0.008) than those who do not develop CD. When the whole follow-up period was analysed (0-6 years), differences between groups in both weight and length/height z-scores were confirmed. Conclusion: The growth of children at risk of CD rarely fell below 'clinical standards'. However, growth rate was significantly lower in cases than in controls. Our data suggest that peculiar pathways of growth are present in children who develop CD, long before any clinical or serological signs of the disease appear
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
gastroenterology
growth
paediatric practice
coeliac disease
Megjelenés:Archives Of Disease In Childhood. - 105 : 10 (2020), p. 964-968. -
További szerzők:Stellato, Pio Bruzzese, Dario Cielo, Donatella Chiurazzi, Alfredo Galatola, Martina Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Crespo-Escobar, Paula Gyimesi Judit Hartman, Corina Kolaček, Sanja Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Mearin, Maria Luisa Meijer, Caroline R. Pieścik-Lech, Magorzata Polanco, Isabel Ribes-Koninckx, Carmen Shamir, Raanan (gyermekgyógyász) Szajewska, Hania (gyermekgyógyász) Troncone, Riccardo Greco, Luigi
Pályázati támogatás:EU- FP6-2005- FOOD4B- contract no. 03638
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2.

001-es BibID:BIBFORM096515
035-os BibID:(cikkazonosító)1335 (WOS)000548695200001 (Scopus)85087496778
Első szerző:Benítez-Páez, Alfonso
Cím:Breast-Milk Microbiota Linked to Celiac Disease Development in Children : a Pilot Study From the PreventCD Cohort / Benítez-Páez Alfonso, Olivares Marta, Szajewska Hania, Piescik-Lech Magorzata, Polanco Isabel, Castillejo Gemma, Nunez Merce, Ribes-Koninckx Carmen, Korponay-Szabó Ilma R., Koletzko Sibylle, Meijer Caroline R., Mearin M. Luisa, Sanz Yolanda
Dátum:2020
ISSN:1664-302X
Megjegyzések:Celiac disease (CeD) is an immune-mediated disorder triggered by exposure to dietary gluten proteins in genetically predisposed individuals. In addition to the host genome, the microbiome has recently been linked to CeD risk and pathogenesis. To progress in our understanding of the role of breast milk microbiota profiles in CeD, we have analyzed samples from a sub-set of mothers (n = 49) included in the PreventCD project, whose children did or did not develop CeD. The results of the microbiota data analysis indicated that neither the BMI, HLA-DQ genotype, the CeD condition nor the gluten-free diet of the mothers could explain the human milk microbiota profiles. Nevertheless, we found that origin country, the offspring's birth date and, consequently, the milk sampling date influenced the abundance and prevalence of microbes in human milk, undergoing a transition from an anaerobic to a more aerobic microbiota, including potential pathogenic species. Furthermore, certain microbial species were more abundant in milk samples from mothers whose children went on to develop CeD compared to those that remained healthy. These included increases in facultative methylotrophs such as Methylobacterium komagatae and Methylocapsa palsarum as well as in species such as Bacteroides vulgatus, that consumes fucosylated-oligosaccharides present in human milk, and other breast-abscess associated species. Theoretically, these microbiota components could be vertically transmitted from mothers-to-infants during breastfeeding, thereby influencing CeD risk
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
breast milk
HLA genotype
celiac disease
children
human milk microbiota
mothers
Megjelenés:Frontiers in Microbiology. - 11 (2020), p. 1-12. -
További szerzők:Olivares, Marta Szajewska, Hania (gyermekgyógyász) Pieścik-Lech, Magorzata Polanco, Isabel Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Nuňez, Merce Ribes-Koninckx, Carmen Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Koletzko, Sibylle Meijer, Caroline R. Mearin, Maria Luisa Sanz, Yolanda
Pályázati támogatás:FP6-2005-FOOD-4B-36383?PREVENTCD
Egyéb
101788
OTKA
TAMOP 2.2.11/1/KONV20 12-0023
TÁMOP
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3.

001-es BibID:BIBFORM069474
Első szerző:Crespo-Escobar, Paula
Cím:The role of gluten consumption at an early age in celiac disease development : a further analysis of the prospective PreventCD cohort study / Crespo-Escobar Paula, Mearin Maria Luisa, Hervás David, Auricchio Renata, Castillejo Gemma, Gyimesi Judit, Martinez-Ojinaga Eva, Werkstetter Katharina, Vriezinga Sabine Lisa, Korponay-Szabo Ilma Rita, Polanco Isabel, Troncone Riccardo, Stoopman Els, Kolaček Sanja, Shamir Raanan, Szajewska Hania, Koletzko Sibylle, Ribes-Koninckx Carmen
Dátum:2017
ISSN:0002-9165
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:American Journal of Clinical Nutrition 105 : 4 (2017), p. 890-896. -
További szerzők:Mearin, Maria Luisa Hervás, David Auricchio, Renata Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Gyimesi Judit Martinez-Ojinaga, Eva Werkstetter, Katharina (gyermekgyógyász, gasztroenterológus) Vriezinga, Sabine Lisa (gyermekgyógyász) Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Polanco, Isabel Troncone, Riccardo Stoopman, Els Kolaček, Sanja Shamir, Raanan (gyermekgyógyász) Szajewska, Hania (gyermekgyógyász) Koletzko, Sibylle Ribes-Koninckx, Carmen
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4.

001-es BibID:BIBFORM101855
Első szerző:Meijer, Caroline R.
Cím:Prediction models for celiac disease development in children from high-risk families : data from the PreventCD cohort / Meijer Caroline R., Auricchio Renata, Putter Hein, Castillejo Gemma, Crespo Paula, Gyimesi Judit, Hartman Corina, Kolacek Sanja, Koletzko Sibylle, Korponay-Szabo Ilma, Ojinaga Eva Martinez, Polanco Isabel, Ribes-Koninckx Carmen, Shamir Raanan, Szajewska Hania, Troncone Riccardo, Villanacci Vincenzo, Werkstetter Katharina, Mearin M. Luisa
Dátum:2022
ISSN:0016-5085
Megjegyzések:Background and aims: Screening for celiac disease (CD) is recommended in children with affected first-degree relatives (FDR). However, the frequency of screening and at what age remain unknown. Aims: to detect variables influencing the risk of CD-development and develop and validate clinical prediction models to provide individualized screening advice. Methods: Analysis of prospective data from the ten years follow-up of the PreventCD-birth cohort involving 944 genetically predisposed children with CD-FDR. Variables significantly influencing the CD-risk were combined to determine a risk score. Landmark analyses were performed at different ages. Prediction models were created by multivariable Cox proportional hazards regression analyses, backward elimination and Harrell's c-index for discrimination. Validation was done using data from the independent NeoCel cohort. Results: In March 2019, the median follow-up was 8.3 years (22 days-12.0 years); 135/944 children developed CD (mean age 4.3years (1.1-11.4). CD developed significantly more often in girls (p=0.005) and in HLA-DQ2 homozygous individuals (8-year cumulative incidence 35.4% versus maximum of the other HLA-risk groups 18.2% [P<0.001]). The effect of homozygosity DR3-DQ2/DR7-DQ2 on CD-developing was only present in girls (interaction p=0.04). The prediction models showed good fitting in the validation cohort (Cox regression 0.81(0.54)). To calculate a personalized risk of CD-development and provide screening advice, we designed the Prediction application https://hputter.shinyapps.io/preventcd/. Conclusion: Children with CD-FDR develop CD early in life, and their risk depends on gender, age and HLA-DQ:all factors which are important for a sound screening advice. These children should be screened early in life, including HLA-DQ2/8-typing, and if genetically predisposed to CD, should get further personalized screening advice using our Prediction app.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
celiac disease
Megjelenés:Gastroenterology. - 163 : 2 (2022), p. 426-436. -
További szerzők:Auricchio, Renata Putter, Hein Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Crespo-Escobar, Paula Gyimesi Judit Hartman, Corina Kolaček, Sanja Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Ojinaga, Eva Martinez Polanco, Isabel Ribes-Koninckx, Carmen Shamir, Raanan (gyermekgyógyász) Szajewska, Hania (gyermekgyógyász) Troncone, Riccardo Villanacci, Vincenzo Werkstetter, Katharina (gyermekgyógyász, gasztroenterológus) Mearin, Maria Luisa
Pályázati támogatás:OTKA-101788
OTKA
TAMOP 2.2.11/1/KONV-2012-0023
TÁMOP
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5.

001-es BibID:BIBFORM109151
035-os BibID:(scopus)85143485531 (wos)000888150500001
Első szerző:Szajewska, Hania
Cím:Systematic review : early feeding practices and the risk of coeliac disease. A 2022 update and revision / Szajewska Hania, Shamir Raanan, Strózyk Agata, Chmielewska Anna, Zalewski Bartomiej M., Auricchio Renata, Koletzko Sibylle, Korponay-Szabo Ilma R., Mearin M. Luisa, Meijer Caroline, Ribes-Koninckx Carmen, Troncone Riccardo, PreventCD project group
Dátum:2023
ISSN:0269-2813 1365-2036
Megjegyzések:Background: The effects of early feeding practices on the risk of coeliac disease (CD) remain debated. Aims: To update evidence on these practices on the risk of CD and/or CD-related autoimmunity (CDA), defined as anti-transglutaminase or anti-endomysial antibody positivity METHODS: We searched MEDLINE, EMBASE and the Cochrane Library to May 2022 for randomised controlled trials (RCTs) and observational studies. Results: We included 36 publications (30 studies). In the population at genetic risk of developing CD (HLA DQ2/DQ8-positive), exclusive or any breastfeeding and longer breastfeeding duration did not reduce the risk of developing CD/CDA during childhood. While a meta-analysis of four case-control studies showed a decreased risk for CD when gluten was introduced during breastfeeding, this was not shown in RCTs and cohort studies. Age at gluten introduction was not associated with cumulative CD/CDA risk, although two RCTs suggested that earlier gluten introduction was associated with earlier CDA appearance. Evidence from six observational studies suggests that consumption of a higher amount of gluten at weaning and/or thereafter may increase CD risk. There is insufficient evidence to determine the amount of gluten associated with an increased CD/CDA risk. Regarding whether infant feeding practices modulate the risk conferred by different HLA genotypes results were inconsistent. Conclusions: For the population at genetic risk of CD, breastfeeding and age at gluten introduction have no effect on its cumulative incidence during childhood. There is some evidence for an effect of the amount of gluten consumed at weaning and/or thereafter on CD/CDA risk.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
celiac disease
infant fedding
Megjelenés:Alimentary Pharmacology & Therapeutics. - 57 : 1 (2023), p. 8-22. -
További szerzők:Shamir, Raanan (gyermekgyógyász) Stróżyk, Agata Chmielewska, Anna Zalewski, Bartomiej Auricchio, Renata Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Mearin, Maria Luisa Meijer, Caroline R. Ribes-Koninckx, Carmen Troncone, Riccardo PreventCD Group
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6.

001-es BibID:BIBFORM100890
035-os BibID:(cikkazonosító)1040 (WoS)000770907500001 (Scopus)85125956936
Első szerző:Szajewska, Hania
Cím:Early Feeding Practices and Celiac Disease Prevention : protocol for an Updated and Revised Systematic Review and Meta-Analysis / Szajewska Hania, Shamir Raanan, Chmielewska Anna, Strózyk Agata, Zalewski Bartomiej, Auricchio Renata, Koletzko Sibylle, Korponay-Szabo Ilma, Mearin Luisa, Meijer Caroline, Ribes-Koninckx Carmen, Troncone Riccardo, PREVENTCD Study Group
Dátum:2022
ISSN:2072-6643
Megjegyzések:Uncertainty remains in regard to when, how, and in what form gluten should be introduced into the diet, particularly of infants genetically predisposed to developing celiac disease (CD). MEDLINE (PubMed), EMBASE, and Cochrane Central Register of Controlled Trials databases will be searched from inception. Randomized controlled trials (RCTs) and observational studies (cohort, case-control, or cross-sectional studies) investigating the association between early feeding practices and the risk of CD and/or CD autoimmunity will be included. In prospective studies, participants will be infants regardless of the risk of developing CD. For retrospective studies, participants will be children or adults with CD or presenting with positive serology indicative of CD. Interventions will be gluten-containing products of any type. Exposures will be breastfeeding and/or the introduction of gluten-containing products of any type. In control groups, there will be no exposure, different degrees of exposure (partial vs. exclusive breastfeeding, different amounts of gluten, etc.), or a placebo. The primary outcome measure will be CD or CD autoimmunity (i.e., anti-transglutaminase or anti-endomysial antibodies). At least two reviewers will independently assess the risk of bias using a validated risk assessment tool depending on study design. Disagreements will be resolved by discussion to achieve a consensus with the involvement of one or more additional reviewers if required. If appropriate, data will be pooled. If not, a narrative synthesis will be performed. The findings will be submitted to a peer-reviewed journal.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
nutrition
feeding
infants
children
celiac sprue
breastfeeding
Megjelenés:Nutrients. - 14 : 5 (2022), p. 1-7. -
További szerzők:Shamir, Raanan (gyermekgyógyász) Chmielewska, Anna Stróżyk, Agata Zalewski, Bartomiej Auricchio, Renata Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Mearin, Maria Luisa Meijer, Caroline R. Ribes-Koninckx, Carmen Troncone, Riccardo PreventCD Group
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7.

001-es BibID:BIBFORM069470
Első szerző:Szajewska, Hania
Cím:Gluten Introduction and the Risk of Coeliac Disease : a Position Paper by the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition / Szajewska Hania, Shamir Raanan, Mearin Luisa, Ribes-Koninckx Carmen, Catassi Carlo, Domellöf Magnus, Fewtrell Mary S., Husby Steffen, Papadopoulou Alexandra, Vandenplas Yvan, Castillejo Gemma, Kolacek Sanja, Koletzko Sibylle, Korponay-Szabó Ilma R., Lionetti Elena, Polanco Isabel, Troncone Riccardo
Dátum:2016
ISSN:0277-2116
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Pediatric Gastroenterology And Nutrition 62 : 3 (2016), p. 507-513. -
További szerzők:Shamir, Raanan (gyermekgyógyász) Mearin, Maria Luisa Ribes-Koninckx, Carmen Catassi, Carlo Domellöf, Magnus Fewtrell, Mary S. Husby, Steffen Papadopoulou, Alexandra Vandenplas, Yvan Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Kolaček, Sanja Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Lionetti, Elena Polanco, Isabel Troncone, Riccardo
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8.

001-es BibID:BIBFORM100413
035-os BibID:(cikkazonosító)734763 (WoS)000735534800001 (Scopus)85121575135
Első szerző:Tan, Ineke L.
Cím:Circulating miRNAs as Potential Biomarkers for Celiac Disease Development / Tan Ineke L., Coutinho de Almeida Rodrigo, Modderman Rutger, Stachurska Anna, Dekens Jackie, Barisani Donatella, Meijer Caroline R., Roca María, Martinez-Ojinaga Eva, Shamir Raanan, Auricchio Renata, Korponay-Szabó Ilma R., Castillejo Gemma, Szajewska Hania, Koletzko Sibylle, Zhernakova Alexandra, Kumar Vinod, Li Yang, Visschedijk Marijn C., Weersma Rinse K., Troncone Riccardo, Mearin M. Luisa, Wijmenga Cisca, Jonkers Iris, Withoff Sebo
Dátum:2021
ISSN:1664-3224
Megjegyzések:Background & Aims: Celiac disease (CeD), an immune-mediated disease with enteropathy triggered by gluten, affects ~1% of the general European population. Currently, there are no biomarkers to predict CeD development. MicroRNAs (miRNAs) are short RNAs involved in post-transcriptional gene regulation, and certain disease- and stage-specific miRNA profiles have been found previously. We aimed to investigate whether circulating miRNAs can predict the development of CeD. Methods: Using next-generation miRNA-sequencing, we determined miRNAs in >200 serum samples from 53 participants of the PreventCD study, of whom 33 developed CeD during follow-up. Following study inclusion at 3 months of age, samples were drawn at predefined ages, diagnosis (first anti-transglutaminase antibody (TGA) positivity or diagnostic biopsy) and after the start of a gluten-free diet (GFD). This allowed identification of circulating miRNAs that are deregulated before TGA positivity. For validation of the biomarkers for CeD and GFD response, two additional cohorts were included in subsequent meta-analyses. Additionally, miRNAs were measured in duodenal biopsies in a case-control cohort. Results: 53 circulating miRNAs were increased (27) or decreased (26) in CeD versus controls. We assessed specific trends in these individual miRNAs in the PreventCD cohort by grouping the pre-diagnostic samples of the CeD patients (all had negative TGA) by how close to seroconversion (first sample positive TGA) the samples were taken. 8/53 miRNAs differed significantly between controls and samples taken <1 year before TGA positivity: miR-21-3p, miR-374a-5p, 144-3p, miR-500a-3p, miR-486-3p let-7d-3p, let-7e-5p and miR-3605-3p. 6/26 downregulated miRNAs reconstituted upon GFD, including miR-150-5p/-3p, whereas no upregulated miRNAs were downregulated upon GFD. 15/53 biomarker candidates also differed between CeD biopsies and controls, with a concordant direction, indicating that these circulating miRNAs might originate from the intestine. Conclusions: We identified 53 circulating miRNAs that are potential early biomarkers for CeD, of which several can be detected more than a year before TGA positivity and some start to normalize upon GFD.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
mall RNA sequencing
pre-diagnostic marker
pre-clinical marker
autoimmunity
celiac disease
Megjelenés:Frontiers in Immunology. - 12 (2021), p. 1-16. -
További szerzők:Coutinho de Almeida, Rodrigo Modderman, Rutger Stachurska, Anna Dekens, Jackie Barisani, Donatella Meijer, Caroline R. Roca, María Martinez-Ojinaga, Eva Shamir, Raanan (gyermekgyógyász) Auricchio, Renata Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Szajewska, Hania (gyermekgyógyász) Koletzko, Sibylle Zhernakova, Alexandra Kumar, Vinod Li, Yang Visschedijk, Marijn C. Weersma, Rinse K. Troncone, Riccardo Mearin, Maria Luisa Wijmenga, Cisca Jonkers, Iris Withoff, Sebo
Pályázati támogatás:NKFI 120392
OTKA
GINOP-2.3.2-15-2016-00015
GINOP
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9.

001-es BibID:BIBFORM056540
Első szerző:Vriezinga, Sabine Lisa
Cím:Randomized feeding intervention in infants at high risk for celiac disease / S. L. Vriezinga, R. Auricchio, E. Bravi, G. Castillejo, A. Chmielewska, P. Crespo Escobar, S. Kolaček, S. Koletzko, I. R. Korponay-Szabo, E. Mummert, I. Polanco, H. Putter, C. Ribes-Koninckx, R. Shamir, H. Szajewska, K. Werkstetter, L. Greco, J. Gyimesi, C. Hartman, C. Hogen Esch, E. Hopman, A. Ivarsson, T. Koltai, F. Koning, E. Martinez-Ojinaga, C. te Marvelde, A. Mocic Pavic, J. Romanos, E. Stoopman, V. Villanacci, C. Wijmenga, R. Troncone, M. L. Mearin
Dátum:2014
ISSN:0028-4793
Megjegyzések:BACKGROUND A window of opportunity has been suggested for reducing the risk of celiac disease by introducing gluten to infants at 4 to 6 months of age. METHODS We performed a multicenter, randomized, double-blind, placebo-controlled dietaryintervention study involving 944 children who were positive for HLA-DQ2 or HLADQ8 and had at least one first-degree relative with celiac disease. From 16 to 24 weeks of age, 475 participants received 100 mg of immunologically active gluten daily, and 469 received placebo. Anti-transglutaminase type 2 and antigliadin antibodies were periodically measured. The primary outcome was the frequency of biopsy-confirmed celiac disease at 3 years of age. RESULTS Celiac disease was confirmed by means of biopsies in 77 children. To avoid underestimation of the frequency of celiac disease, 3 additional children who received a diagnosis of celiac disease according to the 2012 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition diagnostic criteria (without having undergone biopsies) were included in the analyses (80 children; median age, 2.8 years; 59% were girls). The cumulative incidence of celiac disease among patients 3 years of age was 5.2% (95% confidence interval [CI], 3.6 to 6.8), with similar rates in the gluten group and the placebo group (5.9% [95% CI, 3.7 to 8.1] and 4.5% [95% CI, 2.5 to 6.5], respectively; hazard ratio in the gluten group, 1.23; 95% CI, 0.79 to 1.91). Rates of elevated levels of anti-transglutaminase type 2 and antigliadin antibodies were also similar in the two study groups (7.0% [95% CI, 4.7 to 9.4] in the gluten group and 5.7% [95% CI, 3.5 to 7.9] in the placebo group; hazard ratio, 1.14; 95% CI, 0.76 to 1.73). Breast-feeding, regardless of whether it was exclusive or whether it was ongoing during gluten introduction, did not significantly influence the development of celiac disease or the effect of the intervention. CONCLUSIONS As compared with placebo, the introduction of small quantities of gluten at 16 to 24 weeks of age did not reduce the risk of celiac disease by 3 years of age in this group of high-risk children. (Funded by the European Commission and others; PreventCD Current Controlled Trials number, ISRCTN74582487.)
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:New England Journal Of Medicine 371 : 14 (2014), p. 1304-1315. -
További szerzők:Auricchio, Renata Bravi, Enzo (biológus) Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Chmielewska, Anna Crespo-Escobar, Paula Kolaček, Sanja Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Mummert, Eckart Polanco, Isabel Putter, Hein Ribes-Koninckx, Carmen Shamir, Raanan (gyermekgyógyász) Szajewska, Hania (gyermekgyógyász) Werkstetter, Katharina (gyermekgyógyász, gasztroenterológus) Greco, Luigi Gyimesi Judit Hartman, Corina Hogen Esch, Caroline Hopman, Erica Ivarsson, Anneli Koltai Tünde Koning, Frits Martinez-Ojinaga, Eva Marvelde, Chantal te Pavic, Ana Romanos, Jihane Stoopman, Els Villanacci, Vincenzo Wijmenga, Cisca Troncone, Riccardo Mearin, Maria Luisa
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