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001-es BibID:BIBFORM072048
Első szerző:Borrelli, M.
Cím:Intestinal anti-transglutaminase 2 immunoglobulin A deposits in children at risk for coeliac disease (CD) : data from the PreventCD study / Borrelli M., Maglio M., Korponay-Szabó I. R., Vass V., Mearin M. L., Meijer C., Niv-Drori H., Ribes-Koninckx C., Roca M., Shamir R., Troncone R., Auricchio R.
Dátum:2018
ISSN:0009-9104
Megjegyzések:In coeliac disease (CD), anti-tissue transglutaminase 2 immunoglobulin(Ig)A antibodies (anti-TG2) are produced and deposited in the intestine.PreventCD (www.preventcd.com) is a European multi-centre study, whichinvestigates the influence of infant nutrition and that of genetic,immunological and other environmental factors on the risk of developingCD. The aim of the current study was to evaluate the appearance ofintestinal anti-TG2 deposits in very early intestinal biopsies from at-riskinfants and their predictive value for villous atrophy. Sixty-five small bowelbiopsies, performed in 62 children, were investigated for the presenceof intestinal anti-TG2 extracellular IgA deposits by using doubleimmunofluorescence. The biopsies were performed in the presence ofelevated serum levels of CD-associated antibodies and/or symptomssuggesting disease. Deposits of anti-TG2 IgA were present in 53 of 53 CDpatients and three of three potential CD patients. In potential CD patients,mucosal deposits showed a patchy distribution characterized by some areascompletely negative, whereas active CD patients had uniformly present andevident mucosal deposits. Only one of six patients without CD (negative forserum anti-TG2 and with normal mucosa) had intestinal deposits with apatchy distribution and a weak staining. Two of the 53 CD patients receiveda definitive diagnosis of CD after a second or third biopsy; mucosal depositsof anti-TG2 IgA were evaluated in all samples. Before developing villous atrophy, both patients had anti-TG2 deposits in normal mucosalarchitecture, antibodies in one patient being absent in serum. We demonstrated that in CD the intestinal deposits of anti-TG2 are a constant presence and appear very early in the natural history of disease.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
celiac
Megjelenés:Clinical And Experimental Immunology. - 191 : 3 (2018), p. 311-317. -
További szerzők:Maglio, M. Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Vass V. Mearin, Maria Luisa Meijer, Caroline R. Niv-Drori, H. Ribes-Koninckx, Carmen Roca, María Shamir, R. Troncone, Riccardo Auricchio, Renata
Pályázati támogatás:GINOP-2.3.2-15-2016-00015
GINOP
NKFI-120392
NKFI
OTKA-101788
OTKA
Internet cím:DOI
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2.

001-es BibID:BIBFORM096510
035-os BibID:(cikkazonosító)e0197713 (WoS)000487964600088 (Scopus)85071754922
Első szerző:Grunewald, Maria
Cím:Variation and Interdependencies of Human Milk Macronutrients, Fatty Acids, Adiponectin, Insulin, and IGF-II in the European PreventCD Cohort / Grunewald M., Hellmuth C., Kirchberg F. F., Mearin M. L., Auricchio R., Castillejo G., Korponay-Szabo I. R., Polanco I., Roca M., Vriezinga S. L., Werkstetter K., Koletzko B., Demmelmair H.
Dátum:2021
ISSN:2072-6643
Megjegyzések:Background & aims: Breastfeeding is beneficial for mothers and infants. Underlying mechanisms and biochemical mediators thus need to be investigated to develop and support improved infant nutrition practices promoting the child health. We analysed the relation between maternal breast milk composition and infant metabolism. Methods: 196 pairs of mothers and infants from a European research project (PreventCD) were studied. Maternal milk samples collected at month 1 and month 4 after birth were analysed for macronutrient classes, hormone, and fatty acid (FA) content. Phospholipids, acylcarnitines, and amino acids were measured in serum samples of 4-month old infants. Associations between milk components and infant metabolites were analysed with spearman correlation and linear mixed effect models (LME). P-values were corrected for multiple testing (PLME). Results: Month 1 milk protein content was strongly associated with infant serum lyso-phosphatidylcholine (LPC) 14:0 (PLME = 0.009). Month 1 milk insulin was associated to infant acetylcarnitine (PLME = 0.01). There were no associations between milk protein content and serum amino acids and milk total fat content and serum polar lipids. Middle- and odd-chain FA% in breast milk at both ages were significantly related to serum LPC and sphingomyelins (SM) species in infant serum (all PLME<0.05), while FA% 20:5n-3 and 22:6n-3 percentages were significantly associated to serum LPC 22:6 (PLME = 1.91?10-4/7.93?10-5) in milk only at month 4. Other polyunsaturated fatty acids and hormones in milk showed only weak associations with infant serum metabolites. Conclusions: Infant serum LPC are influenced by breast milk FA composition and, intriguingly, milk protein content in early but not late lactation. LPC 14:0, previously found positively associated with obesity risk, was the serum metabolite which was the most strongly associated to milk protein content. Thus, LPC 14:0 might be a key metabolite not only reflecting milk protein intake in infants, but also relating high protein content in milk or infant formula to childhood obesity risk
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
breast milk
coeliac disease
Megjelenés:Nutrients. - 13 : 6 (2021), p. 1-19. -
További szerzők:Hellmuth, Christian Kirchberg, Franca F. Mearin, Maria Luisa Auricchio, Renata Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Polanco, Isabel Roca, María Vriezinga, Sabine Lisa (gyermekgyógyász) Werkstetter, Katharina (gyermekgyógyász, gasztroenterológus) Koletzko, Berthold Demmelmair, Hans
Pályázati támogatás:OTKA-101788
OTKA
NKFIH 120392
OTKA
TAMOP 2.2.11/1/KONV-2012-002
TÁMOP
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM077371
035-os BibID:(cikkazonosító)e0197713 (WOS)000433900800036 (Scopus)85048036551
Első szerző:Hellmuth, Christian
Cím:The impact of human breast milk components on the infant metabolism / Hellmuth Christian, Uhl Olaf, Demmelmair Hans, Grunewald Maria, Auricchio Renata, Castillejo Gemma, Korponay-Szabo Ilma R., Polanco Isabel, Roca María, Vriezinga Sabine L., Werkstetter Katharina J., Koletzko Berthold, Mearin M. Luisa, Kirchberg Franca F.
Dátum:2018
ISSN:1932-6203
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Plos One. - 13 : 6 (2018), p. 1-19. -
További szerzők:Uhl, Olaf Demmelmair, Hans Grunewald, Maria Auricchio, Renata Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Polanco, Isabel Roca, María Vriezinga, Sabine Lisa (gyermekgyógyász) Werkstetter, Katharina (gyermekgyógyász, gasztroenterológus) Koletzko, Berthold Mearin, Maria Luisa Kirchberg, Franca F.
Pályázati támogatás:A101788
OTKA
TAMOP 2.2.11/1/KONV-2012-0023
TÁMOP
NKFI120392
NKFIH
Internet cím:Szerző által megadott URL
DOI
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4.

001-es BibID:BIBFORM103510
035-os BibID:(Wos)000841921200031 (Scopus)85136851907
Első szerző:Mearin, Maria Luisa
Cím:ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease / Mearin Maria Luisa, Agardh Daniel, Antunes Henedina, Al-toma Abdul, Auricchio Renata, Castillejo Gemma, Catassi Carlo, Ciacci Carolina, Discepolo Valentina, Dolinsek Jernej, Donat Ester, Gillett Peter, Guandalini Steffano, Husby Steffen, Koletzko Sibylle, Koltai Tunde, Korponay-Szabó Ilma Rita, Kurppa Kalle, Lionetti Elena, Marild Karl, Martinez Ojinaga Eva, Meijer Caroline, Monachesi Chiara, Polanco Isabel, Popp Alina, Roca Maria, Rodriguez-Herrera Alfonso, Shamir Raanan, Størdal Ketil, Troncone Riccardo, Valitutti Francesco, Vreugdenhil Anita, Wessels Margreet, Whiting Penny, ESPGHAN Special Interest Group on Celiac Disease
Dátum:2022
ISSN:0277-2116
Megjegyzések:Objectives: To gather the current evidence and to offer recommendations for follow-up and management. Methods: The Special Interest Group on Celiac Diseases of the European Society of Paediatric Gastroenterology Hepatology and Nutrition formulated ten questions considered to be essential for follow-up care. A literature search (January 2010-March 2020) was performed in PubMed or Medline. Relevant publications were identified and potentially eligible studies were assessed. Statements and recommendations were developed and discussed by all coauthors. Recommendations were voted upon: joint agreement was set as at least 85%. Results: Publications (n = 2775) were identified and 164 were included. Using evidence or expert opinion, 37 recommendations were formulated on: The need to perform follow-up, its frequency and what should be assessed, how to assess adherence to the gluten-free diet, when to expect catch-up growth, how to treat anemia, how to approach persistent high serum levels of antibodies against tissue-transglutaminase, the indication to perform biopsies, assessment of quality of life, management of children with unclear diagnosis for which a gluten-challenge is indicated, children with associated type 1 diabetes or IgA deficiency, cases of potential celiac disease, which professionals should perform follow-up, how to improve the communication to patients and their parents/caregivers and transition from pediatric to adult health care. Conclusions: We offer recommendations to improve follow-up of children and adolescents with celiac disease and highlight gaps that should be investigated to further improve management.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal Of Pediatric Gastroenterology And Nutrition. - 75 : 3 (2022), p. 369-386. -
További szerzők:Agardh, Daniel Antunes, Henedina Al-toma, Abdul Auricchio, Renata Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Catassi, Carlo Ciacci, Carolina Discepolo, Valentina Dolinśek, Jernej Donat, Ester Gillett, Peter Guandalini, Steffano Husby, Steffen Koletzko, Sibylle Koltai Tünde Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Kurppa, Kalle Lionetti, Elena Marild, Karl Martinez Ojinaga, Eva Meijer, Caroline R. Monachesi, Chiara Polanco, Isabel Popp, Alina Roca, María Rodriguez-Herrera, Alfonso Shamir, Raanan (gyermekgyógyász) Størdal, Ketil Troncone, Riccardo Valitutti, Francesco Vreugdenhil, Anita C. E. Wessels, Margreet Whiting, Penny ESPGHAN Special Interest Group on Celiac Disease
Internet cím:Szerző által megadott URL
DOI
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5.

001-es BibID:BIBFORM100413
035-os BibID:(cikkazonosító)734763 (WoS)000735534800001 (Scopus)85121575135
Első szerző:Tan, Ineke L.
Cím:Circulating miRNAs as Potential Biomarkers for Celiac Disease Development / Tan Ineke L., Coutinho de Almeida Rodrigo, Modderman Rutger, Stachurska Anna, Dekens Jackie, Barisani Donatella, Meijer Caroline R., Roca María, Martinez-Ojinaga Eva, Shamir Raanan, Auricchio Renata, Korponay-Szabó Ilma R., Castillejo Gemma, Szajewska Hania, Koletzko Sibylle, Zhernakova Alexandra, Kumar Vinod, Li Yang, Visschedijk Marijn C., Weersma Rinse K., Troncone Riccardo, Mearin M. Luisa, Wijmenga Cisca, Jonkers Iris, Withoff Sebo
Dátum:2021
ISSN:1664-3224
Megjegyzések:Background & Aims: Celiac disease (CeD), an immune-mediated disease with enteropathy triggered by gluten, affects ~1% of the general European population. Currently, there are no biomarkers to predict CeD development. MicroRNAs (miRNAs) are short RNAs involved in post-transcriptional gene regulation, and certain disease- and stage-specific miRNA profiles have been found previously. We aimed to investigate whether circulating miRNAs can predict the development of CeD. Methods: Using next-generation miRNA-sequencing, we determined miRNAs in >200 serum samples from 53 participants of the PreventCD study, of whom 33 developed CeD during follow-up. Following study inclusion at 3 months of age, samples were drawn at predefined ages, diagnosis (first anti-transglutaminase antibody (TGA) positivity or diagnostic biopsy) and after the start of a gluten-free diet (GFD). This allowed identification of circulating miRNAs that are deregulated before TGA positivity. For validation of the biomarkers for CeD and GFD response, two additional cohorts were included in subsequent meta-analyses. Additionally, miRNAs were measured in duodenal biopsies in a case-control cohort. Results: 53 circulating miRNAs were increased (27) or decreased (26) in CeD versus controls. We assessed specific trends in these individual miRNAs in the PreventCD cohort by grouping the pre-diagnostic samples of the CeD patients (all had negative TGA) by how close to seroconversion (first sample positive TGA) the samples were taken. 8/53 miRNAs differed significantly between controls and samples taken <1 year before TGA positivity: miR-21-3p, miR-374a-5p, 144-3p, miR-500a-3p, miR-486-3p let-7d-3p, let-7e-5p and miR-3605-3p. 6/26 downregulated miRNAs reconstituted upon GFD, including miR-150-5p/-3p, whereas no upregulated miRNAs were downregulated upon GFD. 15/53 biomarker candidates also differed between CeD biopsies and controls, with a concordant direction, indicating that these circulating miRNAs might originate from the intestine. Conclusions: We identified 53 circulating miRNAs that are potential early biomarkers for CeD, of which several can be detected more than a year before TGA positivity and some start to normalize upon GFD.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
mall RNA sequencing
pre-diagnostic marker
pre-clinical marker
autoimmunity
celiac disease
Megjelenés:Frontiers in Immunology. - 12 (2021), p. 1-16. -
További szerzők:Coutinho de Almeida, Rodrigo Modderman, Rutger Stachurska, Anna Dekens, Jackie Barisani, Donatella Meijer, Caroline R. Roca, María Martinez-Ojinaga, Eva Shamir, Raanan (gyermekgyógyász) Auricchio, Renata Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Szajewska, Hania (gyermekgyógyász) Koletzko, Sibylle Zhernakova, Alexandra Kumar, Vinod Li, Yang Visschedijk, Marijn C. Weersma, Rinse K. Troncone, Riccardo Mearin, Maria Luisa Wijmenga, Cisca Jonkers, Iris Withoff, Sebo
Pályázati támogatás:NKFI 120392
OTKA
GINOP-2.3.2-15-2016-00015
GINOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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