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001-es BibID:	BIBFORM096515
035-os BibID:	(cikkazonosító)1335 (WOS)000548695200001 (Scopus)85087496778
Első szerző:	Benítez-Páez, Alfonso
Cím:	Breast-Milk Microbiota Linked to Celiac Disease Development in Children : a Pilot Study From the PreventCD Cohort / Benítez-Páez Alfonso, Olivares Marta, Szajewska Hania, Piescik-Lech Magorzata, Polanco Isabel, Castillejo Gemma, Nunez Merce, Ribes-Koninckx Carmen, Korponay-Szabó Ilma R., Koletzko Sibylle, Meijer Caroline R., Mearin M. Luisa, Sanz Yolanda
Dátum:	2020
ISSN:	1664-302X
Megjegyzések:	Celiac disease (CeD) is an immune-mediated disorder triggered by exposure to dietary gluten proteins in genetically predisposed individuals. In addition to the host genome, the microbiome has recently been linked to CeD risk and pathogenesis. To progress in our understanding of the role of breast milk microbiota profiles in CeD, we have analyzed samples from a sub-set of mothers (n = 49) included in the PreventCD project, whose children did or did not develop CeD. The results of the microbiota data analysis indicated that neither the BMI, HLA-DQ genotype, the CeD condition nor the gluten-free diet of the mothers could explain the human milk microbiota profiles. Nevertheless, we found that origin country, the offspring's birth date and, consequently, the milk sampling date influenced the abundance and prevalence of microbes in human milk, undergoing a transition from an anaerobic to a more aerobic microbiota, including potential pathogenic species. Furthermore, certain microbial species were more abundant in milk samples from mothers whose children went on to develop CeD compared to those that remained healthy. These included increases in facultative methylotrophs such as Methylobacterium komagatae and Methylocapsa palsarum as well as in species such as Bacteroides vulgatus, that consumes fucosylated-oligosaccharides present in human milk, and other breast-abscess associated species. Theoretically, these microbiota components could be vertically transmitted from mothers-to-infants during breastfeeding, thereby influencing CeD risk
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk breast milk HLA genotype celiac disease children human milk microbiota mothers
Megjelenés:	Frontiers in Microbiology. - 11 (2020), p. 1-12. -
További szerzők:	Olivares, Marta Szajewska, Hania (gyermekgyógyász) Pieścik-Lech, Magorzata Polanco, Isabel Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Nuňez, Merce Ribes-Koninckx, Carmen Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Koletzko, Sibylle Meijer, Caroline R. Mearin, Maria Luisa Sanz, Yolanda
Pályázati támogatás:	FP6-2005-FOOD-4B-36383?PREVENTCD Egyéb 101788 OTKA TAMOP 2.2.11/1/KONV20 12-0023 TÁMOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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