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001-es BibID:	BIBFORM035604
Első szerző:	Varga Zsuzsa (biokémikus, nephrológus)
Cím:	Cell surface markers, inositol phosphate levels and membrane potential of lymphocytes from young and old human patients / Varga Zsuzsa, Bressani N., Zaia A. M., Bene László, Fülöp Tamás Jr., Leövey András, Fabris N., Damjanovich Sándor
Dátum:	1990
ISSN:	0165-2478
Megjegyzések:	It is well known that most physiological functions change with aging, including the immune response. Data concerning the aging of lymphocyte subpopulations are conflicting. The antigen density of peripheral blood lymphocytes has been determined by fluorescently tagged OKT-3, OKT-4, OKT-8, OKT-11 and OKM1 monoclonal antibodies in a carefully selected aged (over 87 years) population, and compared to that of young subjects. A substantial difference was found in the percentage distribution of OKT8 and OKM1 subsets. The volume of lymphocytes of the elderly population was significantly less than that of the young. The effect of various monoclonal antibodies on phosphatidylinositol breakdown has also been studied. It was found that only OKT3, acting through the CD3 antigen receptor, was able to induce inositol phosphate formation in both young and elderly, although in the latter population this occurred at a lower level. Because the plasma membrane plays a regulatory role in this process, an important and sensitive functional parameter, the membrane potential, was also monitored and influenced by changing the extracellular K+ concentration. The lymphocytes of the elderly population responded less sensitively to changes in extracellular potassium concentration.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Immunology Letters. - 23 : 4 (1990), p. 275-280. -
További szerzők:	Bressani, N. Zaia, A. M. Fülöp Tamás Jr Leövey András (1926-) (belgyógyász) Fabris, N. Damjanovich Sándor (1936-2017) (biofizikus) Bene László (1963-) (biofizikus)
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001-es BibID:	BIBFORM017329
Első szerző:	Varga Zsuzsa (biokémikus, nephrológus)
Cím:	Effect of elastin peptides and N-formyl-methionyl-leucyl-phenylalanine on cytosolic free calcium in polymorphonuclear leukocytes of healthy middle aged and elderly subjects / Varga Z., Kovács E. M., Paragh G., Jacob M. P., Robert L., Fülöp T. Jr.
Dátum:	1988
ISSN:	0009-9120
Megjegyzések:	The effect of elastin peptides (kappa-elastin, KE) and N-formyl-methionyl-leucyl-phenylalanine (FMLP) on cytosolic free calcium in polymorphonuclear leukocytes (PMNLs) of healthy middle-aged (35-45 years) and elderly (greater than 60 years) patients with normal and high serum cholesterol level was investigated. The cytosolic free calcium [( Ca2+]i) elevation after stimulation with these compounds was decreased in PMNLs of the aged groups compared to the healthy middle-aged group. The guanine nucleotide binding regulatory Gi protein inhibitor, pertussis toxin (PT) prevented the enhancing effect of KE and FMLP on PMNL free calcium of healthy middle-aged subjects, but could not completely abolish the [Ca2+]i elevation in PMNLs of aged subjects.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Clinical Biochemistry. - 21 : 2 (1988), p. 127-130. -
További szerzők:	Kovács M. Éva Paragh György (1953-) (belgyógyász) Jacob, Marie-Paule Robert, Ladislas Fülöp Tamás Jr
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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