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001-es BibID:	BIBFORM116023
035-os BibID:	(Scopus)85175656799
Első szerző:	Kerpel-Fronius Anna
Cím:	HUNCHEST-II contributes to a shift to earlier-stage lung cancer detection : final results of a nationwide screening program / Anna Kerpel-Fronius, Zsolt Megyesfalvi, Zsolt Markóczy...et al., András Székely, Attila Vaskó
Dátum:	2023
ISSN:	1432-1084
Megjegyzések:	Objectives: The introduction of low-dose CT (LDCT) altered the landscape of lung cancer (LC) screening and contributed to the reduction of mortality rates worldwide. Here we report the final results of HUNCHEST-II, the largest population-based LDCT screening program in Hungary, including the screening and diagnostic outcomes, and the characteristics of the LC cases. Methods: A total of 4215 high-risk individuals aged between 50 and 75 years with a smoking history of at least 25 pack-years were assigned to undergo LDCT screening. Screening outcomes were determined based on the volume, growth, and volume doubling time of pulmonary nodules or masses. The clinical stage distribution of screen-detected cancers was compared with two independent practice-based databases consisting of unscreened LC patients. Results: The percentage of negative and indeterminate tests at baseline were 74.2% and 21.7%, respectively, whereas the prevalence of positive LDCT results was 4.1%. Overall, 76 LC patients were diagnosed throughout the screening rounds (1.8% of total participants), out of which 62 (1.5%) patients were already identified in the first screening round. The overall positive predictive value of a positive test was 58%. Most screen-detected malignancies were stage I LCs (60.7%), and only 16.4% of all cases could be classified as stage IV disease. The percentage of early-stage malignancies was significantly higher among HUNCHEST-II screen-detected individuals than among the LC patients in the National Koranyi Institute of Pulmonology's archive or the Hungarian Cancer Registry (p < 0.001). Conclusions: HUNCHEST-II demonstrates that LDCT screening for LC facilitates early diagnosis, thus arguing in favor of introducing systematic LC screening in Hungary. Clinical relevance statement: HUNCHEST-II is the so-far largest population-based low-dose CT screening program in Hungary. A positive test's overall positive predictive value was 58%, and most screen-detected malignancies were early-stage lesions. These results pave the way for expansive systematic screening in the region. Key Points: ? Conducted in 18 medical facilities, HUNCHEST-II is the so far largest population-based low-dose CT screening program in Hungary. ? The vast majority of screen-detected malignancies were early-stage lung cancers, and the overall positive predictive value of a positive test was 58%. ? HUNCHEST-II facilitates early diagnosis, thus arguing in favor of introducing systematic lung cancer screening in Hungary.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Early detection Low-dose computed tomography screening Lung cancer
Megjelenés:	European Radiology. - [Epub ahead of print] (2023). -
További szerzők:	Megyesfalvi Zsolt Markóczy Zsolt Székely András (1982-) (radiológus) Vaskó Attila (1976-) (tüdőgyógyász)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM108988
035-os BibID:	(cikkazonosító)391 (WoS)000940617200001 (Scopus)85149020916
Első szerző:	Kiss Helga
Cím:	Exhaled Biomarkers for Point-of-Care Diagnosis : Recent Advances and New Challenges in Breathomics / Kiss Helga, Örlős Zoltán, Gellért Áron, Megyesfalvi Zsolt, Mikáczó Angéla, Sárközi Anna, Vaskó Attila, Miklós Zsuzsanna, Horváth Ildikó
Dátum:	2023
ISSN:	2072-666X
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Micromachines. - 14 : 2 (2023), p. 1-29. -
További szerzők:	Örlős Zoltán Gellért Áron Megyesfalvi Zsolt Mikáczó Angéla (1980-) (tüdőgyógyász) Sárközi Anna (1974-) (tüdőgyógyász) Vaskó Attila (1976-) (tüdőgyógyász) Miklós Zsuzsanna Horváth Ildikó (1964-) (tüdőgyógyász)
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