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001-es BibID:BIBFORM034931
035-os BibID:PMID:1688147
Első szerző:Ilyés István (gyermekgyógyász, gyermekendokrinológus, háziorvos)
Cím:Brown adipose tissue cell respiration in hypo- and hyperthyroidism after stimulation with selective and non selective beta-adrenergic agonists / I. Ilyés, T. Yahata, M. Stock
Dátum:1991
ISSN:0236-5383
Megjegyzések:Brown adipocyte respiration was measured in isolated cells from hypothyroid, hyperthyroid and euthyroid Sprague-Dawley male rats. Hypothyroidism was induced by providing drinking water containing methimazole and hyperthyroidism was induced by addition of thyroid powder to the diet. Brown adipose tissue (BAT) cells were isolated by collagenase digestion and oxygen consumption (VO2) was measured by Clark type oxygen electrodes. BAT cell respiration was stimulated by selective and nonselective beta-adrenergic agonists: BRL 35135A (BRL) and Isoprenaline (ISO). Basal BAT cells respiration did not differ according to thyroid status. Maximal VO2 responses of BAT adipocytes from hypothyroid rats were significantly lower than in euthyroidism after ISO and BRL. The reduced response was more marked for ISO than for BRL. The thermogenic sensitivity was significantly greater in euthyroid than is hypothyroid cells for ISO, but not for BRL. The euthyroid-hyperthyroid differences were not significantly different. These results suggest: basal respiration of BAT cells in hypo- and hyperthyroidism does not reflect the overall changes in whole body metabolism; the decreased thermogenic response in hypothyroidism might be due to decreased beta-adrenoceptor numbers and/or decreased intracellular thyroxine-triiodothyronine conversion; changes in sensitivity to ISO and BRL in vitro reflect the changes seen in VO2 in vivo.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban
brown adipocyte respiration
hypothyroidism
hyperthyroidism
isoprenaline
BRL 35135A
egyetemen (Magyarországon) készült közlemény
Megjelenés:Acta Biologica Hungarica. - 42 : 4 (1991), p. 345-355. -
További szerzők:Yahata, T. Stock, Michael J.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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