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001-es BibID:BIBFORM033831
Első szerző:Oláh Anna (klinikai biokémikus, vegyész)
Cím:Urinary homogentisic acid in alkaptonuric and healthy children / Anna V. Oláh, István Ilyés, Attila Szőke, István Csízy, Judit Tóth, József Varga
Dátum:2003
ISSN:1434-6621
Megjegyzések:To detect and follow-up the metabolic status of patients with alkaptonuria (AKU), urinary homogentisic acid (HGA) was measured by gas chromatography. These results were close to values we obtained by colorimetric method (linearity: upto 700 mg/l, detection limit: 1 mg/l, within-run imprecision (CV): 1.2% at 100 mg/l HGA, 4.9% at 10 mg/l, between-run CV: 6.8% at 100 mg/l). To determine urinary reference ranges of HGA, 84 healthy children (age: 2 months-18 years) were divided into five age groups. HGA and creatinine were measured in their morning urine. Statistical analysis proved that urinary HGA/creatinine ratio is age-dependent. The ratio is relatively high between 1 and 6 years of age, with large scatter (upper limit of reference ranges given as mean + 2 SD: 5.5-7.2 mg/mmol = 0.03-0.04 mmol/mmol creatinine), and it decreases with age. Approximately at the age of 7 years, HGA/creatinine ratio becomes constant, and later it is similar to the adult value (upper limit: 2.8 mg/ mmol = 0.017 mmol/mmol creatinine). We monitored a patient during her 1-5th year of life, and her urinary HGA was 80-200 times higher than the upper limit of the age-matched reference ranges. The measurement of HGA supports the decision for starting restricted protein diet and is useful for the evaluation of the effectiveness of therapy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Clinical Chemistry And Laboratory Medicine. - 41 : 3 (2003), p. 356-359. -
További szerzők:Ilyés István (1943-) (gyermekgyógyász, gyermekendokrinológus, háziorvos) Szőke Attila Csízy István (1948-) (gyermekgyógyász, gyermeksebész) Tóth Judit Varga József (1955-) (fizikus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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