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001-es BibID:BIBFORM106800
035-os BibID:(WoS)000916972400001 (Scopus)85146808735
Első szerző:Csíkos Csaba
Cím:In Vivo Preclinical Assessment of the VEGF Targeting Potential of the Newly Synthesized [52Mn]Mn-DOTAGA-Bevacizumab Using Experimental Cervix Carcinoma Mouse Model / Csaba Csikos, Adrienn Vágner, Gábor Nagy, Ibolya Kálmán-Szabó, Judit P. Szabó, Minh Toan Ngo, Zoltán Szoboszlai, Dezső Szikra, Zoárd Tibor Krasznai, György Trencsényi, Ildikó Garai
Dátum:2023
ISSN:2075-4418
Megjegyzések:Among humanized monoclonal antibodies, bevacizumab specifically binds to vascular endothelial growth factor A (VEGF-A). VEGF-A is an overexpressed biomarker in cervix carcinoma and is involved in the development and maintenance of tumor-associated neo-angiogenesis. The non-invasive positron emission tomography using radiolabeled target-specific antibodies (immuno-PET) provides the longitudinal and quantitative assessment of tumor target expression. Due to antibodies having a long-circulating time, radioactive metal ions (e.g., 52Mn) with longer half-lives are the best candidates for isotope conjugation. The aim of our preclinical study was to assess the biodistribution and tumor-targeting potential of 52Mn-labeled DOTAGA-bevacizumab. The VEGF-A targeting potential of the new immuno-PET ligand was assessed by using the VEGF-A expressing KB-3-1 (human cervix carcinoma) tumor-bearing CB17 SCID mouse model and in vivo PET/MRI imaging. Due to the high and specific accumulation found in the subcutaneously located experimental cervix carcinoma tumors, [52Mn]Mn-DOTAGA-bevacizumab is a promising PET probe for the detection of VEGF-A positive gynecological tumors, for patient selection, and monitoring the efficacy of therapies targeting angiogenesis.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
52Mn
bevacizumab
cervix carcinoma
positron emission tomography
VEGF
Megjelenés:Diagnostics. - 13 : 2 (2023), p. 236-. -
További szerzők:Vágner Adrienn Nagy Gábor Kálmán-Szabó Ibolya (1980-) (molekuláris biológus) Péli-Szabó Judit (1977-) (vegyész) Ngo, Minh Toan Szoboszlai Zoltán (1980-) (fizikus) Szikra Dezső Péter (1983-) (vegyész) Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász) Trencsényi György (1978-) (biológus, biokémikus, molekuláris biológus) Garai Ildikó (1966-) (radiológus)
Pályázati támogatás:NKFIH K119552
Egyéb
TKP2020-NKA-04
Egyéb
EFOP-3.6.3-VEKOP-16-2017-00009
EFOP
KDP-2021
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM110191
035-os BibID:(cikkazonosító)24 (wos)000957376600001 (scopus)85150973802
Első szerző:Krizsán Áron Krisztián (fizikus)
Cím:Performance evaluation of a novel multi-pinhole collimator on triple-NaI-detector SPECT/CT for dedicated myocardial imaging / Krizsan Aron K., Kukuts Kornel, Al-Muhanna Walid, Szoboszlai Zoltan, Balazs Laszlo, Szabo Balazs, Kiss Janos, Nekolla Stephan, Barna Sandor, Garai Ildiko, Bukki Tamas, Forgacs Attila
Dátum:2023
ISSN:2197-7364
Megjegyzések:Background: In this study we evaluated the imaging capabilities of a novel Multipinhole collimator (MPH-Cardiac) specially designed for nuclear cardiology imaging on a Triple-NaI-detector based SPECT/CT system. Methods: 99mTc point source measurements covering the field of view (FOV) were used to determine tomographic sensitivity ( TSpointsource) and spatial resolution. Organsize tomographic sensitivity ( TSorgan) was measured with a left ventricle (LV) phantom filled with typical myocardial activity of a patient scan. Reconstructed image uniformity was measured with a 140 mm diameter uniform cylinder phantom. Using the LV phantom once filled with 99mTc and after with 123I, Contrast-to-noise ratio (CNR) was measured on the reconstructed images by ROI analysis on the myocardium activity and on the LV cavity. Furthermore, a polar map analysis was performed determining Spill-Over-Ratio in water ( SORwater) and image noise. The results were compared with that of a dual-head parallel-hole low energy high resolution (LEHR) collimator system. A patient with suspected coronary artery disease (CAD) was scanned on the LEHR system using local protocol of 16 min total acquisition time, followed by a 4-min MPH-Cardiac scan. Results: Peak TSpointsource was found to be 1013 cps/MBq in the axial center of the FOV while it was decreasing toward the radial edges. TSorgan in the CFOV was found to be 134 cps/MBq and 700 cps/MBq for the LEHR and MPH-Cardiac, respectively. Average spatial resolution throughout the FOV was 4.38 mm FWHM for the MPH-Cardiac collimator. Reconstructed image uniformity values were found to be 0.292% versus 0.214% for the LEHR and MPH-Cardiac measurements, respectively. CNR was found to be higher in case of MPH-Cardiac than for LEHR in case of 99mTc (15.5 vs. 11.7) as well as for 123I (13.5 vs. 8.3). SORwater values were found to be 28.83% and 21.1% for the 99mTc measurements, and 31.44% and 24.33% for the 123I measurements for LEHR and MPHCardiac, respectively. Pixel noise of the 99mTc polar maps resulted in values of 0.38% and 0.24% and of the 123I polar maps 0.62% and 0.21% for LEHR and MPH-Cardiac, respectively. Visually interpreting the patient scan images, MPH-Cardiac resulted in better image contrast compared to the LEHR technique with four times shorter scan duration.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:EJNMMI Physics. - 10 : 1 (2023), p. 1-16. -
További szerzők:Kukuts Kornél Al-Muhanna, Walid Szoboszlai Zoltán (1980-) (fizikus) Balázs László (fizikus) Szabó Balázs (1991-) (általános orvos) Kiss János (1992-) (fizikus) Nekolla, Stephan Barna Sándor (1982-) (kutató orvos) Garai Ildikó (1966-) (radiológus) Bükki Tamás Forgács Attila (1985-) (fizikus)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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