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1.

001-es BibID:BIBFORM081137
035-os BibID:(PMID)31313247
Első szerző:Barna Sándor (kutató orvos)
Cím:Clinical utility of SPECT/CT and CT-dacryocystography-enhanced dacryoscintigraphy in the imaging of lacrimal drainage system obstruction / Sandor Barna, Ildiko Garai, Kornel Kukuts, Rudolf Gesztelyi, Laszlo Toth, Adam Kemeny-Beke
Dátum:2019
ISSN:0914-7187 1864-6433
Megjegyzések:Purpose Epiphora is commonly caused by a relative or complete occlusion in the lacrimal drainage system (LDS), principally a nasolacrimal duct obstruction (NLDO). Dacryoscintigraphy (DSG), an extensively assessed imaging technique in diagnosing its abnormalities, can provide only planar images, according to which it needs to be improved. Our aim was to evaluate clinical utility of simultaneous DSG and single-photon emission computed tomography/computed tomography (SPECT/CT) combined with computed tomographic dacryocystography (CT-DCG) in the evaluation of LDS. Methods Dynamic imaging with DSG was performed, and tracer radioactivity was detected by a gamma camera. Successively, SPECT/CT images of the involved region were gained, followed by CT-DCG, during which a contrast medium was syringed into the affected LDS, and finally contrast CT scans were obtained again from the same region. Results Fifty-seven patients, mean age 54.25 (? 18.26) years all with unilateral NLDO and 32 control subjects, all with patent LDS, mean age 49.88 (? 18.61) years were evaluated in the study. Delayed outflow of tearing eyes was exposed to DSG compared to the fellow and control eyes. The highest value for sensitivity was observed for SPECT/CT, followed by CT-DCG and DSG techniques, while combining DSG with SPECT/CT, DSG with CT-DCG, and SPECT/CT with CT-DCG, the sensitivity increased to 96.49%, 92.98%, and 94.73%, respectively. Conclusions Although DSG is a sensitive nuclear medicine method, it only provides useful clinical data when simultaneously supplemented with SPECT/CT and CT-DCG trials as they jointly can offer valuable information about the localization of an abnormality and verify stenosis or obstruction.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
dacryoscintigraphy
SPECT/CT
epiphora
Megjelenés:Annals of Nuclear Medicine. - 33 : 10 (2019), p. 746-754. -
További szerzők:Garai Ildikó (1966-) (radiológus) Kukuts Kornél Gesztelyi Rudolf (1969-) (kísérletes farmakológus) Tóth László (1957-) (fül-orr-gégész) Kemény-Beke Ádám (1968-2021) (szemész)
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2.

001-es BibID:BIBFORM075958
Első szerző:Garai Ildikó (radiológus)
Cím:Gastric Motility SPECT/CTwith Tc99m labelled standard quality food (SQF) / Garai I., Forgács A., Kukuts K., Barna S., Opposits G., Kis S. A., Emri M., Csiki Z.
Dátum:2015
ISSN:1619-7070 1619-7089
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:European Journal Of Nuclear Medicine And Molecular Imaging. - 42 : Suppl. 1 (2015), p. S800. -
További szerzők:Forgács Attila (1985-) (fizikus) Kukuts Kornél Barna Sándor (1982-) (kutató orvos) Opposits Gábor (1974-) (fizikus, szoftver fejlesztő) Kis Sándor Attila (1973-) (fizikus) Emri Miklós (1962-) (fizikus) Csiki Zoltán (1962-) (belgyógyász, allergológus, klinikai immunológus, reumatológus)
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3.

001-es BibID:BIBFORM102721
035-os BibID:(Scopus)85137125116
Első szerző:Képes Zita (orvos)
Cím:Initial clinical experience with dedicated multi-pinhole (MPH) collimator for 99mTc-HMPAO brain perfusion SPECT / Zita Képes, Kornél Kukuts, Attila Oszlánszki, Iván Mihovk, Áron Krizsán, Sándor Barna, Andrew Robinson, Daniel Deidda, János Mester, József Varga, Ildikó Garai, Attila Forgács
Dátum:2022
ISSN:1790-5427
Megjegyzések:Abstract Objective: Dedicated multi-pinhole (MPH) collimators have been successfully tested in selected clinical investigations. The aim of our work was to report initial experiences with an MPH collimator set designed for brain perfusion single photon emission tomography (SPECT). Methods: Ten patients underwent sequential technetium-99m-hexamethylpropyleneamineoxime (99mTc-HMPAO) SPECT with a dual-head SPECT camera equipped with conventional low-energy parallel hole collimators (LEHR), and with a triple-head system equipped with MPH collimators. Low-energy parallel hole collimators data were reconstructed by filtered back projection (FBP), ordered subset expectation maximization (OSEM), software for tomographic image reconstruction (STIR). In addition, both the parallel hole data and MPH data were reconstructed by Tera-TomoTM 3D iterative reconstruction denoted LEHR_TT3D and MPH_TT3D, respectively. Five medical experts visually compared the reconstructed images of the five data sets and defined a ranking sequence from the lowest (1) to the highest (5) image quality. Results were compared using the Friedman test. P values below 0.05 were considered significant. Results: Low-energy parallel hole collimators acquisition resulted in 5 million, while MPH acquisition in 13 million total counts with 30 and 34 minutes of acquisition time, respectively. Mean rank coefficients of the reconstruction methods were 1.96?0.52, 2.66?0.46, 2.86?0.60, 3.62?0.55, 3.9?0.68 for FBP, STIR, LEHR_TT3D, LEHR_OSEM, MPH_TT3D respectively. The differences between MPH_TT3D-FBP (P<0.01); MPH_TT3D-STIR (P<0.05); LEHR_OSEM-FBP (P<0.01) were significant. Conclusion: Image quality provided by MPH collimator is comparable to that provided by conventional LEHR imaging. Higher sensitivity has the potential to shorten acquisition time or to reduce the amount of administered activity.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Brain perfusion
SPECT
Multi-pinhole collimator
Reconstruction
Image quality
Megjelenés:Hellenic Journal of Nuclear Medicine. - 25 : 2 (2022), p. 143-147. -
További szerzők:Kukuts Kornél Oszlánszki Attila Mihovk Iván Krizsán Áron Krisztián (1986-) (fizikus) Barna Sándor (1982-) (kutató orvos) Robinson, Andrew Deidda, Daniel Mester János Varga József (1955-) (fizikus) Garai Ildikó (1966-) (radiológus) Forgács Attila (1985-) (fizikus)
Pályázati támogatás:National Grant No. GINOP-2.1.1-15-2015-00609
GINOP
UK National Physical Laboratory through the National Measurement System
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4.

001-es BibID:BIBFORM099030
035-os BibID:(Scopus)85122905153 (WOS)000754954100007
Első szerző:Képes Zita (orvos)
Cím:Homocysteine-related alterations of [18F]FDG brain pattern in metabolic diseases / Zita Képes, Csaba Aranyi, Attila Forgács, Ferenc Nagy, Kornél Kukuts, Regina Esze, Sándor Somodi, Miklós Káplár, József Varga, Miklós Emri, Ildikó Garai
Dátum:2021
ISSN:1790-5427
Megjegyzések:Since hyperhomocysteinaemia (HHcys) is implicated as a risk factor for the development of neurodegeneration, and is associated with the development of metabolic diseases, we aimed at analysing the effect of homocysteine (Hcys) on regional fluorine-18-fluorodeoxyglucose (18F-FDG) brain metabolism in 51 controlled type 2 diabetic and in 48 non-DM obese participants. Plasma Hcys levels were measured by an immunoassay. Homocysteine-related 18F-FDG regional brain metabolism was evaluated applying 18F-FDG PET/CT using magnetic resonance imaging (MRI)-based brain template for Statistical Parametric Mapping (SPM) analysis. Homocysteine-related decreased 18F-FDG uptake was shown in the right middle temporal gyrus in the whole population. Diabetics with Hcys above the reference limit expressed decreased glucose metabolism in the left calcarine cortex compared to the obese with HHcys. Regional metabolic alterations evoked on the basis of HHcys draw attention to the potential risk of neurodegeneration caused by metabolic disturbances.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Diabetes
Obesity
(18)-F-FDG PET/CT
Homocysteine
Neurodegeneration
Megjelenés:Hellenic Journal of Nuclear Medicine. - 24 : 3 (2021), p. 222-227. -
További szerzők:Aranyi Sándor Csaba (1988-) (programtervező informatikus) Forgács Attila (1985-) (fizikus) Nagy Ferenc (1984-) (fizikus) Kukuts Kornél Esze Regina Somodi Sándor (1977-) (belgyógyász) Káplár Miklós (1965-) (belgyógyász, diabetológus) Varga József (1955-) (fizikus) Emri Miklós (1962-) (fizikus) Garai Ildikó (1966-) (radiológus)
Pályázati támogatás:National Grant No. GINOP-2.1.1-15-2015-00609
GINOP
National Brain Research Program No. 2017-1.2.1-NKP-2017-00002
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5.

001-es BibID:BIBFORM098876
035-os BibID:(WoS)000730245900001 (Scopus)85121287053
Első szerző:Képes Zita (orvos)
Cím:Imaging with [99mTc]HMPAO - a novel perspective : investigation of [99mTc] HMPAO leg muscle uptake in metabolic diseases / Zita Képes, Márton Mikó, Kornél Kukuts, Regina Esze, Sándor Barna, Sándor Somodi, Miklós Káplár, József Varga, Ildikó Garai
Dátum:2023
ISSN:0284-1851
Megjegyzések:Background: Sensitive imaging modalities in the diagnosis of microcircular complications of the lower extremities induced by metabolic diseases are becoming a focus of interest. Purpose: To investigate the [99mTc]HMPAO uptake of the legs in type 2 diabetes mellitus (T2DM) and obesity, and to search for associations with clinical parameters and nerve conducting studies. Material and Methods: A total of 57 patients with controlled T2DM and 46 obese participants without DM were enrolled in the study. [99mTc]HMPAO SPECT/CT examinations were performed to evaluate the radiopharmaceutical accumulation of the legs. For the quantitative assessment of tracer uptake, standardized uptake value (SUVpeak) was measured in fixed spheric volumes of interest placed on both sural muscles on the attenuation-corrected images. Measurement of current perception threshold applying Neurometer (NM-01/CPT) was used to evaluate peripheral nerve dysfunction. Laboratory parameters assessing the glucose homeostasis of the study participants were also measured. Results: In the diabetic group, significantly lower leg SUV values were detected compared to the non-DM obese group (median: 0.517 vs. 0.607; P < 0.001). Body mass index (BMI) (P < 0.0001), age (P=0.0283), HbA1c (P =0.0068), and glucose level (P =0.0044) proved to be significant predictors of muscle tracer uptake. Neurometer studies showed positive correlation with HbA1c levels in the T2DM group (P=0.0002). Conclusion: We assume that [99mTc]HMPAO uptake of leg muscles is associated with microcirculation, so quantitative [99mTc]HMPAO SPECT/CT might be a sensitive method for evaluating lower limb microvascular alterations. BMI, age, HbA1c, and glucose level may be significant predictors of peripheral vascular abnormalities triggered by metabolic disturbances. Keywords: [99mTc]HMPAO, lower extremity, microcirculation, polyneuropathy, obesity, type 2 diabetes mellitus
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
[99mTc]HMPAO
lower extremity
microcirculation
polyneuropathy
obesity
type 2 diabetes mellitus
Megjelenés:Acta Radiologica. - 64 : 1 (2023), p. 187-194. -
További szerzők:Mikó Márton (1990-) Kukuts Kornél Esze Regina Barna Sándor (1982-) (kutató orvos) Somodi Sándor (1977-) (belgyógyász) Káplár Miklós (1965-) (belgyógyász, diabetológus) Varga József (1955-) (fizikus) Garai Ildikó (1966-) (radiológus)
Pályázati támogatás:2.1.1-15-2015-00609
GINOP
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6.

001-es BibID:BIBFORM091840
Első szerző:Képes Zita (orvos)
Cím:Examination of brain perfusion and metabolism in metabolic diseases (focusing on diabetes and obesity) / Z. Képes, J. Varga, F. Nagy, K. Kukuts, M. Emri, M. Káplár, Cs. Aranyi, I. Garai
Dátum:2019
Tárgyszavak:Orvostudományok Klinikai orvostudományok nem besorolt
egyéb
További szerzők:Varga József (1955-) (fizikus) Nagy Ferenc (1984-) (fizikus) Kukuts Kornél Emri Miklós (1962-) (fizikus) Káplár Miklós (1965-) (belgyógyász, diabetológus) Aranyi Sándor Csaba (1988-) (programtervező informatikus) Garai Ildikó (1966-) (radiológus)
Pályázati támogatás:GINOP-2.1.1-15-2015-00609
GINOP
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7.

001-es BibID:BIBFORM091785
035-os BibID:(cikkazonosító)3 (WOS)000672838300001 (Scopus)85100999105
Első szerző:Képes Zita (orvos)
Cím:Glucose-level dependent brain hypometabolism in type 2 diabetes mellitus and obesity / Z. Képes, Cs. Aranyi, A. Forgács, F. Nagy, K. Kukuts, Zs. Hascsi, R. Esze, S. Somodi, M. Káplár, J. Varga, M. Emri, I. Garai
Dátum:2021
Megjegyzések:Glucose-level dependent brain hypometabolism in type 2 diabetes mellitus and obesity Background: Metabolic syndrome and its individual components lead to wide-ranging consequences, many of which affect the central nervous system. In this study, we compared the [18F]FDG regional brain metabolic pattern of participants with type 2 diabetes mellitus (T2DM) and non-DM obese individuals. Methods: In our prospective study 51 patients with controlled T2DM (ages 50.6 ? 8.0 years) and 45 non-DM obese participants (ages 52.0 ? 9.6 years) were enrolled. Glucose levels measured before PET/CT examination (pre-PET glucose) as well as laboratory parameters assessing glucose and lipid status were determined. NeuroQ application (NeuroQTM 3.6, Syntermed, Philips) was used to evaluate regional brain metabolic differences. [18F]FDG PET/CT (AnyScan PC, Mediso) scans, estimating brain metabolism were transformed to MNI152 brain map after T1 registration and used for SPM-based group comparison of brain metabolism corrected for pre-PET glucose, and correlation analysis with laboratory parameters. Results: NeuroQ analysis did not reveal significant regional metabolic defects in either group. Voxel-based group comparison revealed significantly (pFWE<0.05) decreased metabolism in the region of the precuneus and in the right superior frontal gyrus (rSFG) in the diabetic group as compared to the obese patients. Data analysis corrected for pre-PET glucose level showed a hypometabolic difference only in the rSFG in T2DM. Voxel-based correlation analysis showed significant negative correlation of the metabolism in the following brain regions with pre-PET glucose in diabetes: precuneus, left posterior orbital gyrus, right calcarine cortex and right orbital part of inferior frontal gyrus; while in the obese group only the right rolandic (pericentral) operculum proved to be sensitive to pre-PET glucose level. Conclusions: To our knowledge this is the first study to perform pre-PET glucose level corrected comparative analysis of brain metabolism in T2DM and obesity. We also examined the pre-PET glucose level dependency of regional cerebral metabolism in the two groups separately. Large-scale future studies are warranted to perform further correlation analysis with the aim of determining the effects of metabolic disturbances on brain metabolism. Keywords: [18F]FDG, metabolism, brain, type 2 diabetes mellitus, obesity
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
[18F]FDG
metabolism
brain
type 2 diabetes mellitus
obesity
Megjelenés:European Journal of Hybrid Imaging. - 5 : 1 (2021), p. 1-15. -
További szerzők:Aranyi Sándor Csaba (1988-) (programtervező informatikus) Forgács Attila (1985-) (fizikus) Nagy Ferenc (1984-) (fizikus) Kukuts Kornél Hascsi Zsolt Esze Regina Somodi Sándor (1977-) (belgyógyász) Káplár Miklós (1965-) (belgyógyász, diabetológus) Varga József (1955-) (fizikus) Emri Miklós (1962-) (fizikus) Garai Ildikó (1966-) (radiológus)
Pályázati támogatás:GINOP-2.1.1-15-2015-00609
GINOP
National Brain Research Program No. 2017-1.2.1-NKP-2017-00002.
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8.

001-es BibID:BIBFORM075950
Első szerző:Kiss A.
Cím:Hand perfusion SPECT/CT using accessories made by 3D printer / Kiss A., Kukuts K., Forgács A., Csiki Z., Nagy L., Garai I.
Dátum:2014
ISSN:1619-7070 1619-7089
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:European Journal Of Nuclear Medicine And Molecular Imaging. - 41 : Suppl. 2 (2014), p. S258. -
További szerzők:Kukuts Kornél Forgács Attila (1985-) (fizikus) Csiki Zoltán (1962-) (belgyógyász, allergológus, klinikai immunológus, reumatológus) Nagy László (Budapest) Garai Ildikó (1966-) (radiológus)
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9.

001-es BibID:BIBFORM110191
035-os BibID:(cikkazonosító)24 (wos)000957376600001 (scopus)85150973802
Első szerző:Krizsán Áron Krisztián (fizikus)
Cím:Performance evaluation of a novel multi-pinhole collimator on triple-NaI-detector SPECT/CT for dedicated myocardial imaging / Krizsan Aron K., Kukuts Kornel, Al-Muhanna Walid, Szoboszlai Zoltan, Balazs Laszlo, Szabo Balazs, Kiss Janos, Nekolla Stephan, Barna Sandor, Garai Ildiko, Bukki Tamas, Forgacs Attila
Dátum:2023
ISSN:2197-7364
Megjegyzések:Background: In this study we evaluated the imaging capabilities of a novel Multipinhole collimator (MPH-Cardiac) specially designed for nuclear cardiology imaging on a Triple-NaI-detector based SPECT/CT system. Methods: 99mTc point source measurements covering the field of view (FOV) were used to determine tomographic sensitivity ( TSpointsource) and spatial resolution. Organsize tomographic sensitivity ( TSorgan) was measured with a left ventricle (LV) phantom filled with typical myocardial activity of a patient scan. Reconstructed image uniformity was measured with a 140 mm diameter uniform cylinder phantom. Using the LV phantom once filled with 99mTc and after with 123I, Contrast-to-noise ratio (CNR) was measured on the reconstructed images by ROI analysis on the myocardium activity and on the LV cavity. Furthermore, a polar map analysis was performed determining Spill-Over-Ratio in water ( SORwater) and image noise. The results were compared with that of a dual-head parallel-hole low energy high resolution (LEHR) collimator system. A patient with suspected coronary artery disease (CAD) was scanned on the LEHR system using local protocol of 16 min total acquisition time, followed by a 4-min MPH-Cardiac scan. Results: Peak TSpointsource was found to be 1013 cps/MBq in the axial center of the FOV while it was decreasing toward the radial edges. TSorgan in the CFOV was found to be 134 cps/MBq and 700 cps/MBq for the LEHR and MPH-Cardiac, respectively. Average spatial resolution throughout the FOV was 4.38 mm FWHM for the MPH-Cardiac collimator. Reconstructed image uniformity values were found to be 0.292% versus 0.214% for the LEHR and MPH-Cardiac measurements, respectively. CNR was found to be higher in case of MPH-Cardiac than for LEHR in case of 99mTc (15.5 vs. 11.7) as well as for 123I (13.5 vs. 8.3). SORwater values were found to be 28.83% and 21.1% for the 99mTc measurements, and 31.44% and 24.33% for the 123I measurements for LEHR and MPHCardiac, respectively. Pixel noise of the 99mTc polar maps resulted in values of 0.38% and 0.24% and of the 123I polar maps 0.62% and 0.21% for LEHR and MPH-Cardiac, respectively. Visually interpreting the patient scan images, MPH-Cardiac resulted in better image contrast compared to the LEHR technique with four times shorter scan duration.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:EJNMMI Physics. - 10 : 1 (2023), p. 1-16. -
További szerzők:Kukuts Kornél Al-Muhanna, Walid Szoboszlai Zoltán (1980-) (fizikus) Balázs László (fizikus) Szabó Balázs (1991-) (általános orvos) Kiss János (1992-) (fizikus) Nekolla, Stephan Barna Sándor (1982-) (kutató orvos) Garai Ildikó (1966-) (radiológus) Bükki Tamás Forgács Attila (1985-) (fizikus)
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10.

001-es BibID:BIBFORM075959
Első szerző:Kukuts Kornél
Cím:Whole body bone SPECT : aspects of methodology / Kukuts K., Fordzyun I., Forgács A., Barna S., Garai I.
Dátum:2015
ISSN:1619-7070 1619-7089
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:European Journal Of Nuclear Medicine And Molecular Imaging. - 42 : Suppl. 1 (2015), p. S839. -
További szerzők:Fordzyun, I. Forgács Attila (1985-) (fizikus) Barna Sándor (1982-) (kutató orvos) Garai Ildikó (1966-) (radiológus)
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11.

001-es BibID:BIBFORM098813
035-os BibID:(cikkazonosító)28 (WoS)000631148700002 (Scopus)85102729201
Első szerző:Nagy Ferenc (fizikus)
Cím:Q-Bot: automatic DICOM metadata monitoring for the next level of quality management in nuclear medicine / Nagy Ferenc, Krizsan Aron K., Kukuts Kornél, Szolikova Melinda, Hascsi Zsolt, Barna Sandor, Acs Antonietta, Szabo Peter, Tron Lajos, Balkay Laszlo, Dahlbom Magnus, Zentai Mihaly, Forgacs Attila, Garai Ildiko
Dátum:2021
ISSN:2197-7364
Tárgyszavak:Természettudományok Fizikai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:EJNMMI Physics. - 8 : 1 (2021), p. 1-13. -
További szerzők:Krizsán Áron Krisztián (1986-) (fizikus) Kukuts Kornél Szolikova, Melinda Hascsi Zsolt Barna Sándor (1982-) (kutató orvos) Ács Antonietta Szabó Péter (nukleáris medicina szakorvos) Trón Lajos (1941-) (biofizikus) Balkay László (1963-) (biofizikus) Dahlbom, Magnus Zentai Mihaly Forgács Attila (1985-) (fizikus) Garai Ildikó (1966-) (radiológus)
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