Találati lista | Tudóstér

001-es BibID:	BIBFORM061229
Első szerző:	Miltényi Zsófia (belgyógyász, haematológus)
Cím:	Prognostic value of interim and restaging PET/CT in Hodgkin lymphoma : results of the CHEAP (Chemotherapy Effectiveness Assessment by PET/CT) study - long term observation. / Z. Miltenyi, S. Barna, I. Garai, Z. Simon, A. Jona, F. Magyari, L. Gergely, Z. Nagy, K. Keresztes, P. Pettendi, A. Illes
Dátum:	2015
Megjegyzések:	Very few studies have determined the prognostic value of interim and restaging PET/CT in patients with Hodgkin lymphoma using current standard of care therapy outside clinical trials. We analyzed the effect of the results of interim and restaging PET/CT on the survival (overall- and relapse-free) in patients who received standard first-line treatment based on the stage of disease and risk factors. We investigated the differences between the relapse and non-relapse groups based on the clinical pathological characteristics of patients who had positive interim PET/CT results. Between January 1, 2007 and December 31, 2011, the staging, interim and restaging PET/CT scans of patients with Hodgkin lymphoma were analyzed. The Deauville criteria were used for the evaluation of interim PET/CT scans. One hundred and thirteen Hodgkin lymphoma patients underwent staging, interim and restaging PET/CT scans. None of the therapy was modified based on the interim PET/CT results. The median follow-up time was 43.5 months. A total of 62 early stage patients and 51 advanced stage patients were identified. The five-year overall survival rates were 93.4% in the interim PET negative group and 58% in the interim PET positive group (p<0.001). The five-year relapse-free survival rates for the negative and positive groups were 92.7% and 40.8%, respectively (p<0.001). The negative predictive value was 100% in the early stage group and 82.35% in the advanced stage group. By comparison, the positive predictive values were 53.8% and 58.8%, respectively, in these two groups. In the interim PET positive group, patients over 40 years of age had a significantly higher probability of relapse (p=0.057). The routine clinical use of interim PET/CT is highly recommended based on our investigation. However, patients with positive interim PET/CT results required frequent additional evaluations.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban predictive value Hodgkin lymphoma PET/CT
Megjelenés:	Neoplasma. - 62 : 4 (2015), p. 627-34. -
További szerzők:	Barna Sándor (1982-) (kutató orvos) Garai Ildikó (1966-) (radiológus) Simon Zsófia (1977-) (belgyógyász, haematológus) Jóna Ádám (1985-) (orvos) Magyari Ferenc (1985-) (orvos) Gergely Lajos (1965-) (belgyógyász, haematológus) Nagy Z. Keresztes Katalin Pettendi Piroska Illés Árpád (1959-) (belgyógyász, haematológus, onkológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM061228
Első szerző:	Simon Zsófia (belgyógyász, haematológus)
Cím:	Combined prognostic value of absolute lymphocyte/monocyte ratio in peripheral blood and interim PET/CT results in Hodgkin lymphoma / Zsofia Simon, S. Barna, Z. Miltenyi, K. Husi, F. Magyari, A. Jona, I. Garai, Z. Nagy, G. Ujj, L. Szerafin, A. Illes
Dátum:	2016
Megjegyzések:	Decreased absolute lymphocyte/monocyte ratio (LMR) in peripheral blood has been reported as an unfavorable prognostic marker in Hodgkin lymphoma. We aimed to investigate whether combining LMR and interim PET/CT scan result (PET2) confers stronger prognostic value than PET2 alone. 121 HL patients were investigated. LMR was calculated from a blood sample taken at the time of diagnosis. PET2 was carried out after the second chemotherapy cycle. Survival was calculated using the Kaplan- Meier method and significance was determined by log-rank test. Effect of variants on survival results was examined using univariate and multivariate analyses. Best LMR cutoff value was determined by receiver operating characteristic (ROC) curve. Best LMR cut-off value was 2.11 in the case of our patients (LMR >2.11: favorable, LMR 2.11: unfavorable). Overall and progression-free survivals (OS/ PFS) were significantly worse both in lower LMR (2.11) (OS: P = 0.041, PFS: P = 0.044) and PET2 positive groups (OS: P < 0.001, PFS: P < 0.001). In PET2 positive patient group (n = 32) the low LMR result meant a significantly worse OS (0.030) and PFS (0.001). Both LMR and PET2 proved to be independent prognostic factors on multivariate analysis, and strengthened each other's effect.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Hodgkin lymphoma Prognostic marker Interim PET/CT Lymphocyte/monocyte ratio
Megjelenés:	International journal of hematology. - 103 : 1 (2016), p. 63-69. -
További szerzők:	Barna Sándor (1982-) (kutató orvos) Miltényi Zsófia (1975-) (belgyógyász, haematológus) Husi Kata (1987-) (hematológus) Magyari Ferenc (1985-) (orvos) Jóna Ádám (1985-) (orvos) Garai Ildikó (1966-) (radiológus) Nagy Z. Ujj György Szerafin László (1958-) (belgyógyászat, haematológia, klinikai onkológia szakorvos) Illés Árpád (1959-) (belgyógyász, haematológus, onkológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: