Találati lista | Tudóstér

001-es BibID:	BIBFORM124078
035-os BibID:	(scopus)85203631691
Első szerző:	Barna Sándor (kutató orvos)
Cím:	[¹³¹I]6β-Iodomethyl-19-norcholesterol SPECT/CT for the Lateralization of Mineralocorticoid Overproduction in Primary Aldosteronism / Barna Sandor, Sira Livia, Bhattoa Harjit Pal, Toth Laszlo, Czine Zsigmond, Szoboszlay Lilla, Nagy Edit B., Kepes Zita, Garai Ildiko, Bodor Miklos, Varga Jozsef, Nagy Endre V.
Dátum:	2024
ISSN:	2075-4418
Megjegyzések:	Primary: aldosteronism is a frequent cause of secondary hypertension. With access to specialized care, an increasing number of patients with aldosteronism are being identified. Primary aldoste-ronism is treatable by adrenal surgery if aldosterone excess originates from one of the two, and not from both, adrenals. Bilateral hyperplasia requires lifelong mineralocorticoid receptor antago-nist treatment. Up till now, adrenal venous sampling (AVS) has been widely used to distinguish between one-sided and two-sided aldosterone overproduction and patient selection for surgery. AVS is an invasive technique, and the unsuccessful sampling of the right adrenal vein during AVS often prevents side comparison, making the AVS procedure useless. Molecular imaging using [131I]6?-iodomethyl-19-norcholesterol with SPECT CT imaging (SPECT/CT) may be a potential al-ternative. Methods: In 42 consecutive patients with confirmed primary aldosteronism, molecular imaging has been performed. After dexamethasone suppression of the non-affected adrenal tis-sue, 37 MBq [131I]6?-iodomethyl-19-norcholesterol was injected i.v., and SPECT/CT images were taken 7 days later. Based on the visual evaluation of the images by two nuclear medicine special-ists, patients with one-sided tracer accumulation underwent adrenalectomy. To identify a SPECT/CT parameter that best characterizes the side difference, the maximum counts and the mean counts of spherical VOIs were analyzed. Results: Of the 42 patients, 24 had one-sided aldos-terone overproduction by SPECT/CT. After surgical removal of the involved adrenal, all 24 pa-tients with SPECT/CT-identified unilateral aldosteronism achieved biochemical cure, defined as a normalized potassium level combined with an aldosterone-to-renin ratio ? 30. To identify the best measurable parameter of SPECT/CT side difference, the mean counts and maximum counts of a series of spherical VOIs of different diameters were analyzed. The ratio of the mean counts of 3 cm spherical VOIs of the right and left adrenal regions (lateralization index) was the best discrimi-nator; a ratio of ?1.29 was characteristic of one-sided disease, without overlap between the one-sided and two-sided patient groups. Conclusions: [131I]6?-iodomethyl-19-norcholesterol SPECT/CT with a count-based image interpretation and side-ratio calculation may be an equipol-lent non-invasive substitute for adrenal venous sampling in the lateralization of mineralocorticoid overproduction. It reliably identifies unilateral disease and facilitates patients' selection for surgical intervention. If confirmed by others, this functional imaging may replace AVS when lateralization is required for management decisions in primary aldosteronism
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk hypertension primary aldosteronism [131I]6?-iodomethyl-19-norcholesterol SPECT/CT
Megjelenés:	Diagnostics. - 14 : 17 (2024), p. 1-10.-
További szerzők:	Sira Lívia (1973-) (endokrinológus) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Tóth László (1971-) (patológus) Czine Zsigmond Szoboszlay Lilla Nagy Edit B. Képes Zita (1991-) (orvos) Garai Ildikó (1966-) (radiológus) Bodor Miklós (1969-) (belgyógyász, endokrinológus) Varga József (1955-) (fizikus) Nagy Endre V. (1957-) (belgyógyász, endokrinológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM093630
Első szerző:	Kovács Dávid Ágoston (sebész)
Cím:	Parathyroid carcinoma : rare endocrine disease / Dávid Ágoston Kovács, Roland Fedor, Mónika Andrási, Sándor Barna, László Tóth, Harjit Pal Bhattoa, Miklós Bodor, Ferenc Győry
Dátum:	2020
ISSN:	0025-0295 1789-4301
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt folyóiratcikk
Megjelenés:	Magyar Sebészet. - 73 : 1 (2020), p. 43-46. -
További szerzők:	Fedor Roland (1975-) (sebész) Andrási Mónika Barna Sándor (1982-) (kutató orvos) Tóth László (1971-) (patológus) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Bodor Miklós (1969-) (belgyógyász, endokrinológus) Győry Ferenc (1964-) (sebész)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: