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001-es BibID:	BIBFORM120196
035-os BibID:	(Scopus)85189985181
Első szerző:	Bedekovics Judit (orvos)
Cím:	Exploring p53 protein expression and its link to TP53 mutation in myelodysplasia-related malignancies - Interpretive challenges and potential field of applications / Judit Bedekovics, Kristóf Madarász, Attila Mokánszki, Sarolta Molnár, Ágnes Mester, Zsófia Miltényi, Gábor Méhes
Dátum:	2024
ISSN:	0309-0167
Megjegyzések:	Aims: TP53 alterations have a significant prognostic effect in myeloid neoplasms. Our objective was to investigate the TP53 gene mutation status, p53 protein expression and their relationship in dysplasia-related myeloid neoplasms with varying levels of myeloblast counts. Methods and results: A total of 76 bone marrow biopsy samples with different blast counts were analysed. Total and strong (3+) p53 expression was determined. Dual immunohistochemical staining was performed to determine the cell population associated with p53 expression. NGS analysis was performed using the Accel-Amplicon Comprehensive TP53 panel. Both p53 expression and TP53 VAF showed a significant correlation with the myeloblast ratio (P?<?0.0001); however, p53 expression was also present in other cell lineages. The VAF value exhibited a significant correlation with p53 expression. A high specificity (0.9800) was observed for TP53 mutation using the ??10% strong (3+) p53 cut-off value, although the sensitivity (0.4231) was low. Conclusions: Strong (3+) p53 expression using a ??10% cut-off value accurately predicts TP53 mutation but does not reveal the allelic state. The p53 expression is significantly influenced by myeloblast count, and histological interpretation should consider the presence of intermixed non-neoplastic marrow cells with varying physiological p53 expression.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk bone marrow myeloblast myelodysplasia p53 expression TP53 mutation
Megjelenés:	Histopathology. - [Epub ahead of print] (2024). -
További szerzők:	Madarász Kristóf (1996-) (biológus) Mokánszki Attila (1983-) (molekuláris biológus Ph.D hallgató) Deliné Molnár Sarolta (1990-) (patológus) Mester Ágnes Miltényi Zsófia (1975-) (belgyógyász, haematológus) Méhes Gábor (1966-) (patológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM076942
Első szerző:	Méhes Gábor (patológus)
Cím:	Hypoxia related carbonic anhydrase IX expression is associated with unfavourable response to first-line therapy in classical Hodgkin's lymphoma / Gábor Méhes, Orsolya Matolay, Lívia Beke, Marianna Czenke, Ádám Jóna, Zsófia Miltényi, Árpád Illés, Judit Bedekovics
Dátum:	2019
ISSN:	0309-0167 1365-2559
Megjegyzések:	The present study evaluates the impact of hypoxia related carbonic anhydrase IX and XII isoenzyme expression as a basic adaptive mechanism to neutralize intracellular acidosis in classical Hodgkin's lymphoma (cHL). METHODS: 81 primary biopsies and 15 relapsed tissue samples diagnosed with cHL were analyzed for necrosis, CAIX and CAXII expression and cell proliferation to compare hypoxia related histological and functional data with survival characteristics. RESULTS: Variable, but highly selective cell membrane CAIX expression could be demonstrated in Hodgkin-Reed-Sternberg (HRS) cells in 39/81 samples (48.1%) while virtually no staining presented in their microenvironment. In contrast, CAXII expression in HRS-cells could be demonstrated in only 18/77 samples (23.4%) with significant stromal positivity (50/77, 64.9%). The CAIX+ phenotype was strongly associated with lymphocyte depletion (4/4, 100%) and nodular sclerosis (29/51, 56.9%) subtypes. CAIX/Ki-67 dual immunohistochemistry demonstrated suppressed cell proliferation in CAIX+ compared to CAIX- HRS-cells (p<0.001). 72 months progression free survival (PFS) was significantly lower for the CAIX+ group (0.192) compared with the CAIX- group (0.771)(p<0.001) while the overall survival (OS) did not differ (p=0.097). CONCLUSION: Hypoxic stress related adaptation - highlighted by CAIX expression - results in cellular quiescence in HRS-cells potentially contributing to the short term failure of the standard chemotherapy in cHL.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Hodgkin's lymphoma adaptation cell cycle hypoxia resistance survival
Megjelenés:	Histopathology. - 74 : 5 (2019), p. 699-708. -
További szerzők:	Matolay Orsolya (1989-) Beke Lívia Czenke Marianna Jóna Ádám (1985-) (orvos) Miltényi Zsófia (1975-) (belgyógyász, haematológus) Illés Árpád (1959-) (belgyógyász, haematológus, onkológus) Bedekovics Judit (1986-) (orvos)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM064057
Első szerző:	Méhes Gábor (patológus)
Cím:	Platelet-derived growth factor receptor [béta] (PDGFR[béta]) immunohistochemistry highlights activated bone marrow stroma and is potentially predictive for fibrosis progression in prefibrotic myeloproliferative neoplasia / Gábor Méhes, Alexandar Tzankov, Konnie Hebeda, Ioannis Anagnostopoulos, László Krenács, Judit Bedekovics
Dátum:	2015
ISSN:	0309-0167
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Myeloproliferative
Megjelenés:	Histopathology. - 67 : 5 (2015), p. 617-624. -
További szerzők:	Tzankov, Alexandar Hebeda, Konnie Anagnostopoulos, Ioannis Krenács László Bedekovics Judit (1986-) (orvos)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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