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001-es BibID:BIBFORM112820
035-os BibID:(scopus)85129859908 (wos)000795504200001
Első szerző:Dundr, Pavel
Cím:The cytokeratin 17 expression in primary ovarian tumors has diagnostic but not prognostic significance / Dundr Pavel, Bazalová Barbora, Bártu Michaela, Bosse Tjalling, Drozenová Jana, Fabian Pavel, Fadare Oluwole, Hausnerová Jitka, Jaksa Radek, Laco Jan, Lax Sigurd F., Matej Radoslav, McCluggage W. Glenn, Méhes Gábor, Michálková Romana, Nemejcová Kristyna, Singh Naveena, Stolnicu Simona, Skapa Petr, Svajdler Marián, Struzinská Ivana
Dátum:2022
ISSN:0945-6317
Megjegyzések:We assessed the value of cytokeratin 17 (CK17) expression for the differential diagnosis between primary ovarian mucinous tumors and metastases from the gastrointestinal tract (GIT) and the significance of CK17 expression in a broad spectrum of primary ovarian tumors with respect to their prognosis. The sample set consisted of 554 primary ovarian tumors and 255 GIT tumors. In the primary ovarian tumors, a higher CK17 expression (in > 10% of tumors cells) was present only in 0?11.4% of all tumors (including mucinous tumors, micropapillary serous borderline tumors, clear cell, endometrioid, and high-grade serous carcinomas). The only exception was low-grade serous carcinoma, where higher CK17 expression was present in 24% of cases. Concerning GIT tumors, the higher levels of CK 17 expression (in > 10% of tumor cells) were observed in the upper GIT tumors (68.5% of pancreatic ductal adenocarcinoma, 61.6% of gallbladder adenocarcinoma, and 46% of gastric adenocarcinoma), which differs substantially not only from most of the primary ovarian tumors, but also from colorectal carcinoma (3.7%; p < 0.001). The results of our study suggest that expression of CK17 can potentially be used as an adjunct marker in differential diagnosis between primary ovarian mucinous tumors and metastases from the upper GIT, but not from colorectal carcinoma. However, in GIT tumors, CK17 can be used in the differential diagnosis between adenocarcinomas of the upper and lower GIT. Statistical analysis did not reveal strong association of CK17 expression with clinicopathological variables or patient outcomes in any primary ovarian tumors.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Virchows Archiv. - 481 : 2 (2022), p. 201-212. -
További szerzők:Bazalová, Barbora Bártủ, Michaela Bosse, Tjalling Drozenová, Jana Fabian, Pavel Fadare, Oluwole Hausnerová, Jitka Jaksa, Radek Laco, Jan Lax, Sigurd F. Matej, Radoslav McCluggage, W. Glenn Méhes Gábor (1966-) (patológus) Michálková, Romana Nĕmejcová, Kristýna Singh, Naveena Stolnicu, Simona Škapa, Petr Svajdler, Marián Struzinská, Ivana
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001-es BibID:BIBFORM106881
035-os BibID:(cikkazonosító)100040 (Scopus)85148085127 (WoS)000982550100001
Első szerző:Dundr, Pavel
Cím:Primary Mucinous Tumors of the Ovary : An Interobserver Reproducibility and Detailed Molecular Study Reveals Significant Overlap Between Diagnostic Categories / Dundr Pavel, Bártu Michaela, Bosse Tjalling, Bui Quang Hiep, Cibula David, Drozenová Jana, Fabian Pavel, Fadare Oluwole, Hausnerová Jitka, Hojny Jan, Hájková Nikola, Jaksa Radek, Laco Jan, Lax Sigurd F., Matej Radoslav, Méhes Gábor, Michálková Romana, Safanda Adam, Nemejcová Kristyna, Singh Naveena, Stolnicu Simona, Svajdler Marián, Zima Tomás, Struzinská Ivana, McCluggage W. Glenn
Dátum:2023
ISSN:0893-3952
Megjegyzések:Primary ovarian mucinous tumors represent a heterogeneous group of neoplasms, and their diagnosis may be challenging. We analyzed 124 primary ovarian mucinous tumors originally diagnosed as mucinous borderline tumors (MBTs) or mucinous carcinomas (MCs), with an emphasis on interobserver diagnostic agreement and the potential for diagnostic support by molecular profiling using a next-generation sequencing targeted panel of 727 DNA and 147 RNA genes. Fourteen experienced pathologists independently assigned a diagnosis from preset options, based on a review of a single digitized slide from each tumor. After excluding 1 outlier participant, there was a moderate agreement in diagnosing the 124 cases when divided into 3 categories (k= 0.524, for mucinous cystadenoma vs MBT vs MC). A perfect agreement for the distinction between mucinous cystadenoma/MBT as a combined category and MC was found in only 36.3% of the cases. Differentiating between MBTs and MCs with expansile invasion was particularly problematic. After a reclassification of the tumors into near-consensus diagnostic categories on the basis of the initial participant results, a comparison of molecular findings between the MBT and MC groups did not show major and unequivocal differences between MBTs and MCs or between MCs with expansile vs infiltrative pattern of invasion. In contrast, HER2 overexpression or amplification was found only in 5.3% of MBTs and in 35.3% of all MCs and in 45% of MCs with expansile invasion. Overall, HER2 alterations, including mutations, were found in 42.2% of MCs. KRAS mutations were found in 65.5% and PIK3CA mutations in 6% of MCs. In summary, although the diagnostic criteria are well-described, diagnostic agreement among our large group of experienced gynecologic pathologists was only moderate. Diagnostic categories showed a molecular overlap. Nonetheless, molecular profiling may prove to be therapeutically beneficial in advanced-stage, recurrent, or metastatic MCs.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Modern Pathology. - 36 : 1 (2023), p. 1-14. -
További szerzők:Bártủ, Michaela Bosse, Tjalling Bui, Quang Hiep Cibula, David Drozenová, Jana Fabian, Pavel Fadare, Oluwole Hausnerová, Jitka Hojny, Jan Hájková, Nikola Jaksa, Radek Laco, Jan Lax, Sigurd F. Matej, Radoslav Méhes Gábor (1966-) (patológus) Michálková, Romana Safanda, Adam Nĕmejcová, Kristýna Singh, Naveena Stolnicu, Simona Svajdler, Marián Zima Tomás Struzinská, Ivana McCluggage, W. Glenn
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