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001-es BibID:	BIBFORM021890
Első szerző:	Czeglédi Levente (agrármérnök)
Cím:	Presence of pituitary adenylate cyclase-activating polypeptide (PACAP) in the plasma and milk of ruminant animals / Czeglédi Levente, Tamás Andrea, Borzsei Rita, Bagoly Teréz, Kiss Péter, Horváth Gabriella, Brubel Réka, Németh József, Szalontai Bálint, Szabadfi Krisztina, Jávor András, Reglódi Dóra, Helyes Zsuzsanna
Dátum:	2011
Megjegyzések:	Milk contains a variety of proteins and peptides that possess biological activity. Growth factors, such as growth hormone, insulin-like, epidermal and nerve growth factors are important milk components which may regulate growth and differentiation in various neonatal tissues and also those of the mammary gland itself. We have recently shown that pituitary adenylate cyclase-activating polypeptide (PACAP), an important neuropeptide with neurotrophic actions, is present in the human milk in much higher concentration than in the plasma of lactating women. Investigation of growth factors in the milk of domestic animals is of utmost importance for their nutritional values and agricultural significance. Therefore, the aim of the present study was to determine the presence and concentration of PACAP in the plasma and milk of three ruminant animal species. Furthermore, the presence of PACAP and its specific PAC1 receptor were investigated in the mammary glands. Radioimmunoassay measurements revealed that PACAP was present in the plasma and the milk of the sheep, goat and the cow in a similar concentration to that measured previously in humans. PACAP38-like immunoreactivity (PACAP38-LI) was 5-20-fold higher in the milk than in the plasma samples of the respective animals, a similar serum/milk ratio was found in all the three species. The levels did not show significant changes within the examined 3-month-period of lactation after delivery. Similar PACAP38-LI was measured in the homogenates of the sheep mammary gland samples taken 7 and 30 days after delivery. PAC1 receptor expression was detected in these udder biopsies by fluorescent immunohistochemistry suggesting that this peptide might have an effect on the mammary glands themselves. These data show that PACAP is present in the milk of various ruminant domestic animal species at high concentrations, the physiological implications of which awaits further investigation.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	General and Comparative Endocrinology. - 172 : 1 (2011), p. 115-119. -
További szerzők:	Tamás Andrea (Idegtudomány) (Pécs) Borzsei Rita (agrár) Bagoly Teréz Kiss Péter Horváth Gabriella Brubel Réka Németh József (1954-) (vegyész, analitikus) Szalontai Bálint (Pécsi Egyetem) Szabadfi Krisztina (Pécsi Egyetem) Jávor András (1952-) (agrármérnök) Reglődi Dóra (Idegtudományok) Helyes Zsuzsanna
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM002473
Első szerző:	Kiss P.
Cím:	Changes of PACAP levels in the brain show gender differences following short-term water and food deprivation / P. Kiss, D. Reglödi, A. Tamás, A. Lubics, I. Lengvári, R. Józsa, A. Somogyvári-Vigh, Z. Szilvássy, J. Németh
Dátum:	2007
Megjegyzések:	Pituitary adenylate cyclase activating polypeptide (PACAP) is a pleiotropic neuropeptide exerting diverse actions in the central and peripheral nervous systems. A few studies indicate that PACAP is involved in the regulation of feeding and water homeostasis. The aim of the present study was to investigate changes in PACAP38 concentrations in diVerent brain areas following food or water deprivation in male and female rats. Rats were sacriWced 12, 36 and 84 h after water or food removal. PACAP levels were determined by radioimmunoassay. Our results show that levels of PACAP decreased in the hypothalamus in both sexes after water deprivation, with a more marked, signiWcant decrease in females at 12 h. A decrease was observed also in the telencephalon, with a similar pattern in both genders: levels were lowest after 12 h, and showed a gradual increase at the other two time-points. PACAP levels increased in the brainstem of male rats, while females had a decrease 12 h after water deprivation. The pattern of changes in PACAP levels was very diVerent after food deprivation. In male rats, PACAP levels showed a signiWcant increase in the hypothalamus, telencephalon and brainstem 12 h after the beginning of starvation. In females, a less marked increase was observed only in the hypothalamus while no changes were found in the other brain areas. Our results show a sensitive reaction in changes of endogenous PACAP levels to water and food deprivation in most brain areas, but they are diVerentially regulated in male and female rats.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Gender differences RIA Starvation CNS
Megjelenés:	General and Comparative Endocrinology. - 152 : 2-3 (2007), p. 225-230. -
További szerzők:	Józsa Rita (Pécs) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Németh József (1954-) (vegyész, analitikus) Reglődi Dóra (Idegtudományok) Tamás Andrea (Idegtudomány) (Pécs) Lubics Andrea (Pécs) Lengvári István Somogyvári-Vigh Anikó
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