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1.

001-es BibID:BIBFORM003873
Első szerző:Boros Ákos
Cím:Changes in the expression of PACAP-like compounds during the embryonic development of the earthworm eisenia fetida / Akos Boros, Dora Reglodi, Zsofia Herbert, Gabor Kiszler, Jozsef Nemeth, Andrea Lubics, Peter Kiss, Andrea Tamas, Seiji Shioda, Kouhei Matsuda, Edit Pollak, Laszló Molnar
Dátum:2008
Megjegyzések:Pituitary adenylate cyclase-activating polypeptide (PACAP) is expressed at very early stages in the vertebrate nervous system, and its functions in the embryonic development have been shown by various studies. PACAP is an extremely conserved molecule in phylogeny; however, little is known about its presence and functions in invertebrates. Our previous studies have shown the occurrence of PACAP-like immunoreactivity in the invertebrate nervous system. The aim of this study was to investigate the presence and localization of PACAP-like compounds during the embryonic development of earthworms from cocoon deposition to hatching using immunological methods (radioimmunoassay, dot blot, immunohistochemistry). PACAP-like immunoreactive compounds were detected at very early stages of the embryonic development of the earthworm Eisenia fetida. No significant changes were observed during the early stages in the developing embryo, but a marked increase occurred before hatching. In contrast, during the embryonic development, the level of PACAP-like compounds gradually decreased in cocoon fluids. Immunohistochemistry revealed the presence of PACAP-like immunoreactive cell bodies and processes in the developing body wall, prostomium, pharyngeal wall, and central nervous system. Cells located in the body wall correspond to putative progenitor cells of primary sensory cells. In the present study, we also showed that the clitellum (reproductive organ) of sexually mature worms contained significantly higher levels of PACAP-like immunoreactivity than other regions of the same animals or the clitellar region of a non-reproducing animal. In summary, these observations provide a morphological basis and suggest a role of PACAP(-like peptides) in the reproductive and developmental functions of invertebrates.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Dot blot
Clitellum
Cocoon
Earthworm
embryo
Primary sensory cells
Radioimmunoassay
Megjelenés:Journal of molecular neuroscience. - 36 : 1-3 (2008), p. 157-165. -
További szerzők:Reglődi Dóra (Idegtudományok) Herbert Zsófia Kiszler Gábor Németh József (1954-) (vegyész, analitikus) Lubics Andrea (Pécs) Kiss Péter Tamás Andrea (Idegtudomány) (Pécs) Shioda, Seiji Matsuda, Kouhei Pollák Edit Molnár László
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2.

001-es BibID:BIBFORM008849
Első szerző:Börzsei Rita
Cím:Presence of pituitary adenylate cyclase activating polypeptide-38 in human plasma and milk / Rita Borzsei, Laszlo Mark, Andrea Tamas, Terez Bagoly, Csaba Bay, Katalin Csanaky, Eszter Banki, Peter Kiss, Alexandra Vaczy, Gabriella Horvath, Jozsef Nemeth, Edit Szauer, Zsuzsanna Helyes, Dora Reglodi
Dátum:2009
ISSN:0804-4643 (Print)
Megjegyzések:Pituitary adenylate cyclase activating polypeptide (PACAP) is a pleiotropic and multifunctional neuropeptide widely distributed throughout the body. It is involved in the regulation of various physiological and pathophysiological processes, such as reproduction, thermoregulation, motor activity, brain development, neuronal survival, inflammation and pain. Since little is known about its distribution in humans, our aim was to examine PACAP-38 in human plasma. Furthermore, based on the presence of vasoactive intestinal peptide, structurally the closest to PACAP, in milk and PACAP and its receptors in the mammary gland, our aim was to study PACAP-38 in human milk.Design and methods: The presence of PACAP-38 was determined by mass spectrometry in plasma samples from healthy male and female volunteers (age: 20-40), as well as in plasma and milk samples from lactating women (age: 20-35). PACAP concentration was measured with a specific and sensitive RIA. Results: Our results revealed that PACAP-38 is present in human plasma, its concentration is relatively stable in healthy volunteers and it is not significantly altered by gender, age, food intake or hormonal cycle in females. However, PACAP-38 plasma levels significantly increased in lactating women having 1-6 month-old babies. Moreover, this study is the first which provides evidence for the presence of PACAP-38 in the human milk with levels 5-20-fold greater in the milk whey than in the respective plasma samples. Conclusions: We found PACAP-38 in human plasma and its increase during the first 6 months of the lactation period. A prominent, nearly 10-fold higher concentration of this peptide was detected in human milk. Based on the literature, several important actions of milk-derived PACAP-38 can be suggested such as mammary gland proliferation, nutrient transfer as well as regulation of growth/differentiation of certain tissues of the neonates. The novelty of the present descriptive data provides a basis for further investigations on the mechanism of PACAP-38 secretion in human milk and its functional significance.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
PACAP-38 human plasma, human milk
Megjelenés:European Journal of Endocrinology. - 160 : 4 (2009), p. 561-565. -
További szerzők:Márk László (1956-) (belgyógyász, kardiológus) Tamás Andrea (Idegtudomány) (Pécs) Bagoly Teréz Bay Csaba Csanaky Katalin Bánki Eszter Kiss Péter Váczy Alexandra Horváth Gabriella Németh József (1954-) (vegyész, analitikus) Szauer Edit Helyes Zsuzsanna Reglődi Dóra (Idegtudományok)
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3.

001-es BibID:BIBFORM031291
Első szerző:Brubel Réka
Cím:Presence of pituitary adenylate cyclase activating polypeptide and its type I receptor in the rat kidney / Brubel R., Horvath G., Reglodi D., Lubics A., Tamas A., Kiss P., Laszlo E., Nemeth J., Mark L., Szakaly P.
Dátum:2011
Megjegyzések:Pituitary adenylate cyclase activating polypeptide (PACAP), a multifunctional neuropeptide,has 2 active forms, PACAP38 and PACAP27. It is now well-established that PACAPhas several actions also in peripheral organs, including renoprotective effects. The peptideitself has not been previously identified in the rat kidney. The first aim of our study was toidentify PACAP in the rat kidney using mass spectrometry and radioimmunoassay (RIA).Receptor mRNA and binding studies revealed the existence of all 3 PACAP receptors(PAC1, VPAC1, and VPAC2) in the kidney, but their exact localization in histologicsections was not evident. Because most of the cytoprotective effects of PACAP relate to itsspecific PAC1 receptor, our second aim was to identify the cell types wherein the PAC1receptor is expressed in the rat kidney. Mass spectrometry revealed the presence ofPACAP38 in the kidney. RIA measurements showed both PACAP38- and PACAP27-likeimmunoreactivities in kidney homogenates, with PACAP38 being dominant. Immunohistochemistryrevealed PAC1 receptor-like immunoreactivity in kidney sections, mainlyexpressed in cortical tubular epithelial cells. These results showed PACAP to beendogenously present in the kidney. The tubular localization of the PAC1 receptorprovides the basis for the renal effects of the peptide under physiologic and pathologicconditions.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
PACAP38
PACAP27
rat kidney
receptor
Megjelenés:Transplantation Proceedings. - 43 : 4 (2011), p. 1297-1299. -
További szerzők:Horváth Gábor (Pécs) Reglődi Dóra (Idegtudományok) Lubics Andrea (Pécs) Tamás Andrea (Idegtudomány) (Pécs) Kiss Péter (Pécs) László E. Németh József (1954-) (vegyész, analitikus) Mark L. Szakály Péter
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4.

001-es BibID:BIBFORM021890
Első szerző:Czeglédi Levente (agrármérnök)
Cím:Presence of pituitary adenylate cyclase-activating polypeptide (PACAP) in the plasma and milk of ruminant animals / Czeglédi Levente, Tamás Andrea, Borzsei Rita, Bagoly Teréz, Kiss Péter, Horváth Gabriella, Brubel Réka, Németh József, Szalontai Bálint, Szabadfi Krisztina, Jávor András, Reglódi Dóra, Helyes Zsuzsanna
Dátum:2011
Megjegyzések:Milk contains a variety of proteins and peptides that possess biological activity. Growth factors, such as growth hormone, insulin-like, epidermal and nerve growth factors are important milk components which may regulate growth and differentiation in various neonatal tissues and also those of the mammary gland itself. We have recently shown that pituitary adenylate cyclase-activating polypeptide (PACAP), an important neuropeptide with neurotrophic actions, is present in the human milk in much higher concentration than in the plasma of lactating women. Investigation of growth factors in the milk of domestic animals is of utmost importance for their nutritional values and agricultural significance. Therefore, the aim of the present study was to determine the presence and concentration of PACAP in the plasma and milk of three ruminant animal species. Furthermore, the presence of PACAP and its specific PAC1 receptor were investigated in the mammary glands. Radioimmunoassay measurements revealed that PACAP was present in the plasma and the milk of the sheep, goat and the cow in a similar concentration to that measured previously in humans. PACAP38-like immunoreactivity (PACAP38-LI) was 5-20-fold higher in the milk than in the plasma samples of the respective animals, a similar serum/milk ratio was found in all the three species. The levels did not show significant changes within the examined 3-month-period of lactation after delivery. Similar PACAP38-LI was measured in the homogenates of the sheep mammary gland samples taken 7 and 30 days after delivery. PAC1 receptor expression was detected in these udder biopsies by fluorescent immunohistochemistry suggesting that this peptide might have an effect on the mammary glands themselves. These data show that PACAP is present in the milk of various ruminant domestic animal species at high concentrations, the physiological implications of which awaits further investigation.
Tárgyszavak:Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:General and Comparative Endocrinology. - 172 : 1 (2011), p. 115-119. -
További szerzők:Tamás Andrea (Idegtudomány) (Pécs) Borzsei Rita (agrár) Bagoly Teréz Kiss Péter Horváth Gabriella Brubel Réka Németh József (1954-) (vegyész, analitikus) Szalontai Bálint (Pécsi Egyetem) Szabadfi Krisztina (Pécsi Egyetem) Jávor András (1952-) (agrármérnök) Reglődi Dóra (Idegtudományok) Helyes Zsuzsanna
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5.

001-es BibID:BIBFORM008847
Első szerző:Ferencz Andrea
Cím:Influence of PACAP on oxidative stress and tissue injury following small-bowel autotransplantation / Ferencz A., Racz B., Tamas A., Reglodi D., Lubics A., Nemeth J., Nedvig K., Kalmar-Nagy K., Horvath O. P., Weber G., Roth E.
Dátum:2009
Megjegyzések:Abstract Tissue injury caused by cold preservation and reperfusion remains an unsolved problem during smallbowel transplantation. Pituitary adenylate cyclase-activating polypeptide (PACAP) is present and plays a central role in the intestinal physiology. This study investigated effect of PACAP-38 on the oxidative stress and tissue damage in autotransplanted intestine. Sham-operated, ischemia/reperfusion, and autotransplanted groups were established in Wistar rats. In ischemia/reperfusion groups, 1 h (group A), 2 h (group B), and 3 h (group C) ischemia followed by 3 h of reperfusion was applied. In autotransplanted groups, total orthotopic intestinal autotransplantation was performed. Grafts were preserved in University of Wisconsin (UW) solution and in UW containing 30 ?g PACAP-38 for 1, 2, 3, and 6 h. Reperfusion lasted 3 h in all groups. Endogenous PACAP-38 concentration was measured by radioimmunoassay. To determine oxidative stress parameters, malondialdehyde, reduced glutathione, and superoxide dismutase were measured in tissue samples. Tissue damage was analyzed by qualitative and quantitative methods on hematoxylin/eosinstained sections. Concentration of endogenous PACAP-38 significantly decreased in groups B and C compared to sham-operated group. Preservation solution containing PACAP-38 ameliorated bowel tissue oxidative injury induced by cold ischemia and reperfusion. Histological results showed that preservation caused destruction of the mucous, submucous, and muscular layers, which were further deteriorated by the end of reperfusion. In contrast, PACAPJ-38 significantly protected the intestinal structure. Ischemia/ reperfusion decreased the endogenous PACAP-38 concentration in the intestinal tissue. Administration of PACAP-38 mitigated the oxidative injury and histological lesions in small-bowel autotransplantation model.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Small-bowel transplantation
Megjelenés:Journal of Molecular Neuroscience. - 37 : 2 (2009), p. 168-176. -
További szerzők:Rácz Boglárka Tamás Andrea (Idegtudomány) (Pécs) Reglődi Dóra (Idegtudományok) Lubics Andrea (Pécs) Németh József (1954-) (vegyész, analitikus) Nedvig Klára Kalmár-Nagy Károly Horváth Örs Péter (sebész) Wéber György Rőth Erzsébet (1957-) (vegyész)
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6.

001-es BibID:BIBFORM003867
Első szerző:Hernádi László
Cím:The presence and distribution of pituitary adenylate cyclase activating polypeptide and its receptor in the snail helix pomatia / L. Hernádi, Z. Pirger, T. Kiss, J. Németh, L. Mark, P. Kiss, A. Tamas, A. Lubics, G. Toth, S. Shioda, D. Reglodi
Dátum:2008
Megjegyzések:The aim of this study was to show the presence, distribution and function of the pituitary adenylate cyclase activating polypeptide (PACAP) and its receptors in the CNS and peripheral nervous system of the mollusk, Helix pomatia. PACAP-like and pituitary adenylate cyclase activating polypeptide receptor (PAC1-R)-like immunoreactivity was abundant both in the CNS and the peripheral nervous system of the snail. In addition several non-neuronal cells also revealed PACAP-like immunoreactivity. In inactive animals labeled cell bodies were mainly found and in the neuropile of active animals dense immunostained fiber system was additionally detected suggesting that expression of PACAP-like peptide was affected by the behavioral state of the animal. RIA measurements revealed the existence of both forms of PACAP in the CNS where the 27 amino acid form was found to be dominant. The concentration of PACAP27 was significantly higher in samples from active animals supporting the data obtained by immunohistochemistry. In Western blot experiments PACAP27 and PACAP38 antibodies specifically labeled protein band at 4.5 kDa both in rat and snail brain homogenates, and additionally an 14 kDa band in snail. The 4.5 kDa protein corresponds to PACAP38 and the 14 kDa protein corresponds to the preproPACAP or to a PACAP-like peptide having larger molecular weight than mammalian PACAP38. In matrix-assisted laser desorption ionization time of flight (MALDI TOF) measurements fragments of PACAP38 were identified in brain samples suggesting the presence of a large molecular weight peptide in the snail. Applying antibodies developed against the PACAP receptor PAC1-R, immunopositive stained neurons and a dense network of fibers were identified in each of the ganglia. In electrophysiological experiments, extracellular application of PACAP27 and PACAP38 transiently depolarized or increased postsynaptic activity of neurons expressing PAC1-R. In several neurons PACAP elicited a long lasting hyperpolarization which was eliminated after 1.5 h continuous washing. Taken together, these results indicate that PACAP may have significant role in a wide range of basic physiological functions in snail.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
pituitary adenylate cyclase activating polypeptide,
Megjelenés:Neuroscience. - 155 : 2 (2008), p. 387-402. -
További szerzők:Pirger Zsolt Kiss Tibor Németh József (1954-) (vegyész, analitikus) Márk László (1956-) (belgyógyász, kardiológus) Kiss Péter Tamás Andrea (Idegtudomány) (Pécs) Lubics Andrea (Pécs) Tóth Gábor Shioda, Seiji Reglődi Dóra (Idegtudományok)
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7.

001-es BibID:BIBFORM013279
Első szerző:Horváth Gabriella
Cím:Mice deficient in pituitary adenylate cyclase activating polypeptide display increased sensitivity to renal oxidative stress in vitro / Gabriella Horvath, Laszlo Mark, Reka Brubel, Peter Szakaly, Boglarka Racz, Peter Kiss, Andrea Tamas, Zsuzsanna Helyes, Andrea Lubics, Hitoshi Hashimoto, Akemichi Baba, Norihito Shintani, Gergely Furjes, Jozsef Nemeth, Dora Reglodi
Dátum:2010
Megjegyzések:Pituitary adenylate cyclase activating polypeptide (PACAP) is a multifunctional neuropeptide, showingwidespread occurrence in the nervous system and also in peripheral organs. The neuroprotective effectsof PACAP are well-established in different neuronal systems against noxious stimuli in vitro and in vivo.Recently, its general cytoprotective actions have been recognized, including renoprotective effects. However,the effect of endogenous PACAP in the kidneys is not known. The main aim of the present studywas to investigate whether the lack of this endogenous neuropeptide influences survival of kidney cellsagainst oxidative stress. First, we determined the presence of endogenous PACAP from mouse kidneyhomogenates by mass spectrometry and PACAP-like immunoreactivity by radioimmunoassay. Second,primary cultures were isolated from wild type and PACAP deficient mice and cell viability was assessedfollowing oxidative stress induced by 0.5, 1.5 and 3mM H2O2. Our mass spectrometry and radioimmunoassayresults show that PACAP is endogenously present in the kidney. The main part of our studyrevealed that the sensitivity of cells from PACAP deficient mice was increased to oxidative stress: bothafter 2 or 4 h of exposure, cell viability was significantly reduced compared to that from control wild typemice. This increased sensitivity of kidneys from PACAP deficient mice could be counteracted by exogenouslygiven PACAP38. These results show, for the first time, that endogenous PACAP protects againstoxidative stress in the kidney, and that PACAP may act as a stress sensor in renal cells. These findingsfurther support the general cytoprotective nature of this neuropeptide.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Cell viability
Oxidative stress
PACAP knockout mice
Renoprotection
Megjelenés:Neuroscience Letters. - 469 : 1 (2010), p. 70-74. -
További szerzők:Márk László (1956-) (belgyógyász, kardiológus) Brubel Réka Szakály Péter Rácz Boglárka Kiss Péter Tamás Andrea (Idegtudomány) (Pécs) Helyes Zsuzsanna Lubics Andrea (Pécs) Hashimoto, Hitoshi Baba, Akemichi Shintani Norihito Fürjes Gergely Németh József (1954-) (vegyész, analitikus) Reglődi Dóra (Idegtudományok)
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8.

001-es BibID:BIBFORM040221
Első szerző:Józsa Rita (Pécs)
Cím:Presence of PACAP and VIP in embryonic chicken brain / Jozsa R., Hollosy T., Nemeth J., Tamás A., Lubics A., Jakab B., Olah A., Arimura A., Reglödi D.
Dátum:2006
ISSN:0077-8923
Megjegyzések:The aim of the present article was to investigate the occurrenceand temporary changes of pituitary adenylate cyclase-activatingpolypeptide (PACAP)-38 and vasoactive intestinal peptide (VIP) in variousbrain areas of chicken embryos by means of radioimmunoassay. Thehighest concentrations of PACAP-38 were measured in the brain stemfollowed by the hypothalamus, cerebellum, and telencephalon. PACAP-38 levels were significantly higher than those of VIP in all examinedbrain areas. The levels of both PACAP-38 and VIP showed a tendency todecrease until hatching during embryonic development of the chicke
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Annals Of The New York Academy Of Sciences. - 1070 : 1 (2006), p. 348-353. -
További szerzők:Hollósy Tibor (Pécs) Németh József (1954-) (vegyész, analitikus) Tamás Andrea (Idegtudomány) (Pécs) Lubics Andrea (Pécs) Jakab Balázs (Pécs) Oláh András Arimura, Akira Reglődi Dóra (Idegtudományok)
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9.

001-es BibID:BIBFORM087705
Első szerző:Kiss Péter (Pécs)
Cím:Presence of PACAP-38 in mammalian plasma and milk : from guinea pig to humans / Kiss P., Csanaky K., Bánki E., Tamás A., Börzsei R., Márk L., Bagoly T., Bay Cs., Váczy A., Horváth G., Németh J., Czeglédi L., Szauer E., Helyes Zs., Reglődi D.
Dátum:2010
ISSN:0231-424X 1588-2683
Megjegyzések:PACAP is a pleiotropic and multifunctional neuropeptide widely distributed throughout the body. It is involved in the regulation of various physiological and pathophysiological processes, such as reproduction, thermoregulation, motor activity, brain development, neuronal survival, inflammation and pain. Since little is known about its distribution in humans, our aim was to examine PACAP-38 in human plasma. Furthermore, based on the presence of VIP, structurally the closest to PACAP, in milk, and presence of PACAP- and PACAP receptor-immunoreactive elements in the mammary gland, our aim was also to examine PACAP-38 in human milk. For comparative studies, we investigated presence of PACAP in plasma and milk of other species, including goat, sheep, cow and guinea pig. Methods. The presence of PACAP-38 was determined by mass spectrometry in plasma samples from healthy male and female volunteers (age: 20?40), in plasma and milk samples from lactating women (age: 20?35). PACAP concentration was measured with a specific and sensitive radioimmunoassay in human and other mammalian samples. Results. Our results revealed that PACAP-38 is present in human plasma, its concentration is relatively stable in healthy volunteers and it is not significantly altered by gender, age, food intake or the hormonal cycle in females. However, PACAP-38 plasma levels significantly increased in lactating women having 1?6-month-old babies. Moreover, this study is the first which provides evidence for the presence of PACAP-38 in the human milk with levels 5?20-fold greater in the milk whey than in the respective plasma samples. The same ratio was found in all other examined species. Conclusions. Based on the present findings and the literature, several important actions of milk-derived PACAP-38 can be suggested such as mammary gland proliferation, nutrient transfer as well as regulation of growth/differentiation of certain tissues of the neonates.
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
folyóiratcikk
PACAP-38
Megjelenés:Acta Physiologica Hungarica. - 97 : 1 (2010), p. 115. -
További szerzők:Csanaky Katalin Bánki Eszter Tamás Andrea (Idegtudomány) (Pécs) Börzsei Rita Márk László Bagoly Teréz Bay Csaba Váczy Alexandra Horváth Gabriella Németh József (1954-) (vegyész, analitikus) Czeglédi Levente (1977-) (agrármérnök) Szauer Edit Helyes Zsuzsanna Reglődi Dóra (Idegtudományok)
Pályázati támogatás:K72592
OTKA
K73044
OTKA
F67830
OTKA
78480
OTKA
K75965
OTKA
Gedeon Richter Centenary Foundation
Egyéb
Janos Bolyai Postdoctoral Research Fellowship
Egyéb
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10.

001-es BibID:BIBFORM002473
Első szerző:Kiss P.
Cím:Changes of PACAP levels in the brain show gender differences following short-term water and food deprivation / P. Kiss, D. Reglödi, A. Tamás, A. Lubics, I. Lengvári, R. Józsa, A. Somogyvári-Vigh, Z. Szilvássy, J. Németh
Dátum:2007
Megjegyzések:Pituitary adenylate cyclase activating polypeptide (PACAP) is a pleiotropic neuropeptide exerting diverse actions in the central and peripheral nervous systems. A few studies indicate that PACAP is involved in the regulation of feeding and water homeostasis. The aim of the present study was to investigate changes in PACAP38 concentrations in diVerent brain areas following food or water deprivation in male and female rats. Rats were sacriWced 12, 36 and 84 h after water or food removal. PACAP levels were determined by radioimmunoassay. Our results show that levels of PACAP decreased in the hypothalamus in both sexes after water deprivation, with a more marked, signiWcant decrease in females at 12 h. A decrease was observed also in the telencephalon, with a similar pattern in both genders: levels were lowest after 12 h, and showed a gradual increase at the other two time-points. PACAP levels increased in the brainstem of male rats, while females had a decrease 12 h after water deprivation. The pattern of changes in PACAP levels was very diVerent after food deprivation. In male rats, PACAP levels showed a signiWcant increase in the hypothalamus, telencephalon and brainstem 12 h after the beginning of starvation. In females, a less marked increase was observed only in the hypothalamus while no changes were found in the other brain areas. Our results show a sensitive reaction in changes of endogenous PACAP levels to water and food deprivation in most brain areas, but they are diVerentially regulated in male and female rats.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Gender differences
RIA
Starvation
CNS
Megjelenés:General and Comparative Endocrinology. - 152 : 2-3 (2007), p. 225-230. -
További szerzők:Józsa Rita (Pécs) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Németh József (1954-) (vegyész, analitikus) Reglődi Dóra (Idegtudományok) Tamás Andrea (Idegtudomány) (Pécs) Lubics Andrea (Pécs) Lengvári István Somogyvári-Vigh Anikó
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11.

001-es BibID:BIBFORM020435
Első szerző:Németh József (vegyész, analitikus)
Cím:Changes in PACAP levels in the central nervous system after ovariectomy and castration / Nemeth J., Tamas A., Jozsa R., Horvath J. E., Jakab B., Lengvari I., Arimura A., Lubics A., Reglódi D.
Dátum:2006
Megjegyzések:The aim of the present article was to investigate the influenceof gonadectomy on pituitary adenylate cyclase-activating polypeptide(PACAP) levels in different brain areas. In males, there seems tobe an inverse relationship between gonadotropins and PACAP in thebrain in the acute phase of castration: PACAP levels decreased in almostall brain areas examined within the first week after castration. Infemales, such pattern was observed in the hypothalamus, brain stem,and temporal cortex. In the pituitary, levels decreased only on the firstday after ovariectomy, and later, as in the thalamus, increases were observed.Although the pattern of change showed gender differences, ourresults provide further evidence that levels of gonadotropins and possiblygonadotropin-releasing hormone influence PACAP levels and thatPACAP is involved in the regulation of gonadal functions.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
ovariectomy
castration
PACAP
Megjelenés:Annals of the New York Academy of Sciences. - 1070 (2006), p. 468-473. -
További szerzők:Tamás Andrea (Idegtudomány) (Pécs) Józsa Rita (Pécs) Horváth Judit E. (New Orleans) Jakab Balázs (Pécs) Lengvári István Arimura, Akira Lubics Andrea (Pécs) Reglődi Dóra (Idegtudományok)
Internet cím:DOI
Borító:

12.

001-es BibID:BIBFORM003049
Első szerző:Németh József (vegyész, analitikus)
Cím:PACAP-27 radioimmunoassay : description and application of a novel method / J. Nemeth, B. Jakab, R. Jozsa, T. Hollossy, A. Tamas, A. Lubics, I. Lengvari, P. Kiss, Zs. Oberritter, B. Horvath, Z. Szilvassy, D. Reglődi
Dátum:2007
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény hazai lapban
PACAP-27 radioimmunoassay
Megjelenés:Journal of Radioanalytical and Nuclear Chemistry. - 273 : 2 (2007), p. 327-332. -
További szerzők:Jakab Balázs (Pécs) Józsa Rita (Pécs) Hollósy Tibor (Pécs) Tamás Andrea (Idegtudomány) (Pécs) Lubics Andrea (Pécs) Lengvári István Kiss P. Oberritter Zsolt Horváth B. Reglődi Dóra (Idegtudományok) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus)
Internet cím:elektronikus változat
DOI
Borító:
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