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001-es BibID:BIBFORM032396
Első szerző:Shujaa, N.
Cím:a2-Adrenoceptor agonist-induced inhibition of gastric motor activity is mediated by a2A-adrenoceptor subtype in the mouse / N. Shujaa, M. Al-Khrasani, Z. S. Zádori, M. Rossi, P. Mátyus, J. Németh, L. Hein, K. Gyires
Dátum:2011
ISSN:0197-0186
Megjegyzések:Therole ofa2-adrenoceptors in regulationof gastricmotility has beenwell documented.However, onlyfewdata are available on the adrenoceptor subtype that mediates this effect. The purpose of the present workwas to identify the a2-adrenoceptor subtype(s) responsible for the inhibition of gastric motor activity inisolated fundus strip of the mouse. It was shown that (i) the electrically evoked contraction of the gastricfundus strip of the mouse was inhibited by the non-selective a2-adrenoceptor stimulant clonidine (EC50:0.019 0.001 mM), the a2A-adrenoceptor subtype selective agonist oxymetazoline (EC50: 0.004 0.001 mM)and the a2B-adrenoceptor subtype preferring ST-91 (EC50: 0.029 0.004 mM), (ii) the inhibitory effect ofclonidine (1 mM), oxymetazoline (0.1 mM) and ST-91 (1 mM) on the contractions of gastric fundus strip wasreversed by the non-selective a2-adrenoceptor antagonist idazoxan and a2A-adrenoceptor antagonist BRL44408, but not by the a2B/2C-adrenoceptor antagonist ARC-239. (iii) Clonidine and ST-91 inhibited theelectrically induced gastric contractions in C57BL/6 wild type mice as well as in a2B- and a2C-adrenoceptordeficient mice in a concentration-dependent manner; however, neither of themwas effective in a2A-deficientmice. As a conclusion, it was first demonstrated that the inhibitory effect of a2-adrenoceptor agonists on thegastric motor activity of isolated stomach strip of the mouse is mediated purely by a2A-adrenoceptors.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Gastric fundus strip a2-Adrenoceptor subtype deficient mice
Megjelenés:Neurochemistry International. - 58 : 6 (2011), p. 708-713. -
További szerzők:Al-Khrasani, Mahmoud Zádori Zoltán S. (Farmakológia, gasztrointesztinális farmakológia) Rossi, Mauro Mátyus Péter (1962-) (vegyész) Németh József (1954-) (vegyész, analitikus) Hein L. Gyires Klára
Internet cím:DOI
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