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001-es BibID:	BIBFORM008850
Első szerző:	Somogyi Ildikó
Cím:	Pituitary Adenylate Cyclase-activating Polypeptide-like Compounds Could Modulate the Activity of Coelomocytes in the Earthworm / Ildiko Somogyi, Akos Boros, Peter Engelmann, Eszter Varhalmi, Jozsef Nemeth, Andrea Lubics, Andrea Tamas, Peter Kiss, Dora Reglodi, Edit Pollak, Laszlo Molnar
Dátum:	2009
Megjegyzések:	By means of radioimmunoassay, we studied the concentration of pituitary adenylate cyclase-activating polypeptide (PACAP)-like proteins in intact and regenerating earthworms. Transection of animals increased the concentration of PACAP-like compounds in coelomocytes, and a decreasing rostrocaudal gradient was detected in the regenerating animals. Western blot analysis revealed a range of PAC1-receptor proteins with molecular weights from 40 to 80 kDa. Electron microscopic immunocytochemistry showed that PAC1 receptors were located on distinct sets of coelomocytes (mainly on amebocytes and on some granulocytes). Based on our results we hypothesize a link between PACAP and coelomocytes, suggesting that PACAP modulates the function of amebocytes and certain granulocytes that play a role in tissue remodeling of regenerating earthworms.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban radioimmunoassay Western blot immunocytochemistry Eisenia fetida
Megjelenés:	Annals of the New York Academy of Sciences. - 1163 (2009), p. 521-523. -
További szerzők:	Boros Ákos Engelmann, Peter Várhalmi Eszter Németh József (1954-) (vegyész, analitikus) Lubics Andrea (Pécs) Tamás Andrea (Idegtudomány) (Pécs) Kiss Péter Reglődi Dóra (Idegtudományok) Pollák Edit Molnár László
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001-es BibID:	BIBFORM003871
Első szerző:	Várhalmi Eszter
Cím:	Expression of PACAP-Like compounds during the caudal regeneration of the earthworm eisenia fetida / Eszter Varhalmi, Ildiko Somogyi, Gabor Kiszler, Jozsef Nemeth, Dora Reglodi, Andrea Lubics, Peter Kiss, Andrea Tamas, Edit Pollak, Laszlo Molnar
Dátum:	2008
Megjegyzések:	The regeneration of the ventral nerve cord ganglion and peripheral tissues was investigated by radioimmunoassay and immunohistochemistry in the model animal, Eisenia fetida (Annelida, Oligochaeta). It is now well-established that pituitary adenylate cyclase-activating polypeptide (PACAP) is a neurotrophic factor, playing important roles in the development of the nervous system in vertebrate animals. Based on the apparent evolutionary conservation of PACAP and on the several common mechanisms of vertebrate and invertebrate nervous regeneration, the question was raised whether PACAP has any role in the regeneration of the earthworm nervous system. As a first step, we studied the distribution, concentration, and time-course of PACAP-like immunoreactivity during caudal regeneration of both lost segments and the ventral nerve cord ganglia in E. fetida. A strong upregulation of PACAP-like immunoreactivity was observed in most tissues following injury as determined by radioimmunoassay and immunohistochemistry. Significant increases in the concentration of PACAP-like compounds were found in the body wall, alimentary canal, and in coelomocytes. The most characteristic morphological feature was the accumulation of immunolabeled neoblasts in the injured tissues, especially in the ventral nerve cord ganglion that initiates and mediates regeneration processes. Our present results show that PACAP/PACAP-like peptides accumulate in the regenerating tissues of the earthworm, suggesting trophic functions of these compounds in earthworm tissues similarly to vertebrate species.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Annelida Coelomocyte Neoblast RIA Regeneration Regeneration blastema
Megjelenés:	Journal of Molecular Neuroscience. - 36 : 1-3 (2008), p. 166-174. -
További szerzők:	Somogyi Ildikó Kiszler Gábor Németh József (1954-) (vegyész, analitikus) Reglődi Dóra (Idegtudományok) Lubics Andrea (Pécs) Kiss Péter Tamás Andrea (Idegtudomány) (Pécs) Pollák Edit Molnár László
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