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001-es BibID:	BIBFORM042638
Első szerző:	Tuka Bernadett
Cím:	Peripheral and central alterations of pituitary adenylate cyclase activating polypeptide-like immunoreactivity in the rat in response to activation of the trigeminovascular system / Bernadett Tuka, Zsuzsanna Helyes, Adrienn Markovics, Teréz Bagoly, József Németh, László Márk, Réka Brubel, Dóra Reglődi, Árpád Párdutz, János Szolcsányi, László Vécsei, János Tajti
Dátum:	2012
ISSN:	0196-9781
Megjegyzések:	Pituitary adenylate cyclase activating polypeptide (PACAP) is present in the cranial arteries and trigeminalsensory neurons. We therefore examined the alterations in PACAP-like immunoreactivity (PACAP-LI) ina time-dependent manner in two rat models of trigeminovascular system (TS) activation. In one groupchemical stimulation (CS) was performed with i.p. nitroglycerol (NTG), and in the other one the trigeminalganglia (TRG) were subjected to electrical stimulation (ES). The two biologically active forms, PACAP-38and PACAP-27, were determined by means of radioimmunoassay (RIA) and mass spectrometry (MS) inthe plasma, the cerebrospinal fluid (CSF), the trigeminal nucleus caudalis (TNC), the spinal cord (SC) andthe TRG. The tissue concentrations of PACAP-27 were 10 times lower than those of PACAP-38 in the TNCand SC, but about half in the TRG. PACAP-38, but not PACAP-27, was present in the plasma. Neither formcould be identified in the CSF. PACAP-38-LI in the plasma, SC and TRG remained unchanged after CS, butit was increased significantly in the TNC 90 and 180 min after NTG injection. In response to ES of the TRG,the level of PACAP-38 in the plasma and the TNC was significantly elevated 90 and 180 min later, but notin the SC or the TRG. The alterations in the levels of PACAP-27 in the tissue homogenates in responseto both forms of stimulation were identical to those of PACAP-38. The selective increases in both formsof PACAP in the TNC suggest its important role in the central sensitization involved in migraine-likeheadache.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Peptides. - 33 : 2 (2012), p. 307-316. -
További szerzők:	Helyes Zsuzsanna Markovics Adrienn Bagoly Teréz Németh József (1954-) (vegyész, analitikus) Márk László Brubel Réka Reglődi Dóra (Idegtudományok) Párdutz Árpád Szolcsányi János (Pécs) Vécsei László (1954-) (neurológus) Tajti János
Pályázati támogatás:	OTKA-75965 OTKA
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM008848
Első szerző:	Zidverc-Trajkovic, Jasna
Cím:	Calcitonin gene-related peptide levels in saliva of patients with burning mouth syndrome / Jasna Zidverc-Trajkovic, Dragan Stanimirovic, Radmila Obrenovic, János Tajti, László Vécsei, János Gardi, József Németh, Milija Mijajlovic, Nadezda Sternic, Ljiljana Jankovic
Dátum:	2009
Megjegyzések:	Burning mouth syndrome (BMS) is an intraoral burning sensation for which no medical or dental cause can be found. Recent studies suggest that primary neuropathic dysfunction might be involved in the pathogenesis of BMS. Calcitonin gene-related peptide (CGRP) plays an important role in the development of pain and serves as a biological marker of trigeminovascular activation. The aim of this study was to determine the levels of CGRP in the saliva of BMS patients and estimate the trigeminovascular activation in BMS. CGRP levels were measured, by RIA method in 78 BMS patients and 16 healthy subjects. The levels of CGRP were non-significantly decreased in BMS patients in comparison to healthy subjects. These results suggest that trigeminal nerve degeneration may be the underlying cause of BMS.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban burning mouth syndrome calcitonin gene-related
Megjelenés:	Journal of Oral Pathology and Medicine. - 38 : 1 (2009), p. 29-33. -
További szerzők:	Stanimirovic, Dragan Obrenovic, Radmila Tajti János Vécsei László (1954-) (neurológus) Gardi János Németh József (1954-) (vegyész, analitikus) Mijajlovic, Milija Sternic, Nadezda Jankovic, Ljiljana
Internet cím:	elektronikus változat elektronikus változat DOI
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