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001-es BibID:	BIBFORM061062
Első szerző:	Helyes Zsuzsanna
Cím:	Pituitary Adenylate Cyclase-Activating Polypeptide Is Upregulated in Murine Skin Inflammation and Mediates Transient Receptor Potential Vanilloid-1-Induced Neurogenic Edema / Zsuzsanna Helyes, Jozsef Kun, Nora Dobrosi, Katalin Sándor, Jozsef Németh, Aniko Perkecz, Erika Pintér, Krisztina Szabadfi, Balazs Gaszner, Valeria Tékus, Janos Szolcsányi, Martin Steinhoff, Hitoshi Hashimoto, Dora Reglődi, Tamas Bíró
Dátum:	2015
ISSN:	0022-202X
Megjegyzések:	Although pituitary adenylate cyclase-activating polypeptide (PACAP) was described as a key vasoregulator inhuman skin, little is known about its expression in mouse skin. As it is important to investigate PACAP signaling intranslational mouse dermatitis models, we determined its presence, regulation, and role in neurogenic and nonneurogeniccutaneous inflammatory mechanisms. The mRNA of PACAP and its specific receptor PAC1 wasdetected with real-time PCR in several skin regions at comparable levels. PACAP-38-immunoreactivity measuredwith radioimmunoassay was similar in plantar and dorsal paw skin and the ear but significantly smaller in theback skin. PACAP and PAC1 mRNA, as well as PACAP-38 and PAC1 protein expression, significantly increased in theplantar skin after intraplantar administration of capsaicin (50 ?l, 100 ?gml?1), an agonist of the transient receptorpotential vanilloid 1 (TRPV1) receptor, evoking chiefly neurogenic inflammation without inflammatory cellaccumulation. Intraplantar complete Freund's adjuvant (CFA; 50 ?l, 1mgml?1) also increased PACAP/PAC1 mRNAbut not the PACAP peptide. Capsaicin-induced neurogenic paw edema, but not CFA-evoked non-neurogenicswelling, was significantly smaller in PACAP-deficient mice throughout a 24-hour period. To our knowledge, weprovide previously unreported evidence for PACAP and PAC1 expression upregulation during skin inflammation ofdifferent mechanisms and for its pro-inflammatory function in neurogenic edema formation.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban cross-talk sebaceous gland sebocytes skin homeostasis
Megjelenés:	Journal Of Investigative Dermatology 135 : 9 (2015), p. 2209-2218. -
További szerzők:	Kun József Dobrosi Nóra (1981-) (molekuláris biológus) Sándor Katalin Németh József (1954-) (vegyész, analitikus) Perkecz Anikó Pintér Erika Szabadfi Krisztina (Pécsi Egyetem) Gaszner Balázs (Neuroanatómia) Tékus Valéria Szolcsányi János (Pécs) Steinhoff, Martin Hashimoto, Hitoshi Reglődi Dóra (Idegtudományok) Bíró Tamás (1968-) (élettanász)
Pályázati támogatás:	OTKA-104984 OTKA OTKA-PD100706 OTKA OTKA-101761 OTKA OTKA105369 OTKA TÁMOP-4.2.2./A-11/1/KONV-2012-0025 TÁMOP TÁMOP-4.2.4.A/ 2- 11/1-2012-0001 TÁMOP
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001-es BibID:	BIBFORM078047
Első szerző:	Sárszegi Zsolt
Cím:	Examination of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) as a Potential Biomarker in Heart Failure Patients / Zsolt Sarszegi, Dora Szabo, Balazs Gaszner, Attila Konyi, Dora Reglodi, Jozsef Nemeth, Beata Lelesz, Beata Polgar, Adel Jungling, Andrea Tamas
Dátum:	2019
ISSN:	0895-8696 1559-1166
Megjegyzések:	Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic and multifunctional neuropeptide having neurotrophic, neuroprotective, and general cytoprotective actions in a variety of tissues based on its anti-apoptotic, anti-inflammatory, and antioxidant effects. Several studies have demonstrated its cardioprotective effects in vitro and in various animal models. However, few data are available on the presence of PACAP in human cardiac tissues and its role in the pathomechanism and progression of different cardiac disorders, particularly heart failure. Earlier, our research group has shown PAC1 receptor immunoreactivity in human heart tissue samples and we have found significantly elevated PACAP27- and PACAP38-like immunoreactivity in ischemic cardiac samples compared to valvular abnormalities with radioimmunoassay. In the last few years, numerous studies examined the presence and the changes of PACAP levels in different human tissue samples and biological fluids to show alterations in different physiological and pathological conditions. Therefore, the aim of the present study was to measure the alterations of blood PACAP levels in chronic heart failure caused by primary dilated cardiomyopathy or ischemic cardiomyopathy and to examine the possible relationship between serum levels of PACAP, N-terminal prohormone of brain natriuretic peptide (NT-proBNP), and systolic left ventricular function, the most reliable biomarkers of heart failure. In the group of mild heart failure patients, a significant strong negative correlation was detected. Furthermore, in moderate heart failure, we found a significant moderate negative correlation between PACAP and NT-proBNP levels only in ischemic subgroup. Positive correlation was found between serum PACAP level and ejection fraction only in patientswith heart failure due to ischemic cardiomyopathy but not in patients with primary dilated cardiomyopathy. In summary, remarkable differences were observed between the ischemic and non-ischemic heart failure suggesting that PACAP might play an important role in the pathomechanism and progression of ischemic heart failure and it might be a potential biomarker of cardiac diseases in the future.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Dilated cardiomyopathy Heart failure NT-proBNP PACAP
Megjelenés:	Journal of Molecular Neuroscience. - 68 : 3 (2019), p. 368-376. -
További szerzők:	Szabó Dóra Gaszner Balázs (Neuroanatómia) Kónyi Attila Reglődi Dóra (Idegtudományok) Németh József (1954-) (vegyész, analitikus) Lelesz Beáta (1989-) (molekuláris biológus) Polgár Beáta Jungling Adél Tamás Andrea (Idegtudomány) (Pécs)
Pályázati támogatás:	K119759 OTKA GINOP-2.3.2-15-2016-00050 OTKA EFOP-3.6.1-16-2016-00004 EFOP EFOP-3.6.2-16-2017-00009 EFOP EFOP-3.6.2-16-2017-00008 EFOP TAMOP 4.2.4.A/2-11-1-2012-0001 TÁMOP UNKP-16-4-IV New National Excellence Program of the Ministry of Human Capacities UNKP
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001-es BibID:	BIBFORM042640
035-os BibID:	PMID:22648511
Első szerző:	Szántó Zoltán
Cím:	PACAP immunoreactivity in human malignant tumor samples and cardiac diseases / Z. Szanto, Zs. Sarszegi, D. Reglodi, J. Nemeth, K. Szabadfi, P. Kiss, A. Varga, E. Banki, K. Csanaky, B. Gaszner, O. Pinter, Zs. Szalai, A. Tamas
Dátum:	2013
Megjegyzések:	Pituitary adenylate cyclase activating polypeptide(PACAP) is a pleiotropic and multifunctional neuropeptidehaving important roles in various physiological processes.Recent trends in PACAP research point to the clinical introductionof PACAP or its analogs/fragments possibly in thenear future. Recently, we have shown the presence ofPACAP in human plasma, milk, placenta, and follicularfluid samples. However, relatively few data are availableon PACAP in human tissues from patients with differentdisorders. The aim of the present study was to determine, byradioimmunoassay, the tissue level of PACAP38-like immunoreactivity(LI) and PACAP27-LI in different primary nonsmallcell lung cancer, colon tumor samples, and in cardiacmuscle samples from patients suffering from ischemic heartdisease and valvular disorders. We also labeled the PAC1receptors in human cardiac cells. All samples showed significantlyhigher PACAP38-LI compared with PACAP27-LI. We found significantly lower levels of PACAP38-LI andPACAP27-LI in tumoral and peripheral samples comparedwith normal healthy tissue in both lung and colon cancers.Further investigations are necessary to describe the exactfunction of PACAP in oncogenesis. We showed thatPACAP38-LI and PACAP27-LI are significantly higher inischemic heart diseases compared with valvular abnormalities,suggesting that PACAP might play a role in ischemicheart disorders.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban PACAP Colon cancer Lung cancer Heart disorder PAC1 receptor egyetemen (Magyarországon) készült közlemény
Megjelenés:	Journal of Molecular Neuroscience. - 48 : 3 (2013), p. 667-673. -
További szerzők:	Sárszegi Zsolt Reglődi Dóra (Idegtudományok) Németh József (1954-) (vegyész, analitikus) Szabadfi Krisztina (Pécsi Egyetem) Kiss P. Varga A. (anatómia, Pécs) Bánki Eszter Csanaky Katalin Gaszner Balázs (Neuroanatómia) Pintér Olivér Szalai Zsuzsanna Tamás A. (Pécs)
Pályázati támogatás:	OTKA-75965 OTKA OTKA-72592 OTKA
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