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001-es BibID:BIBFORM049713
Első szerző:Drimba László (farmakológus)
Cím:In Vivo Preclinical Evaluation of a Promising Antiarrhythmic Agent, EGIS-7229 / László Drimba, Jozsef Nemeth, Réka Sári, Yin Di, Anikó Kovács, Gábor Szénási, Zoltán Szilvássy, Barna Peitl
Dátum:2013
ISSN:0272-4391
Megjegyzések:The basic hemodynamic, electrophysiological, and pharmacological effects of EGIS-7229(E-7229) were evaluated and compared with those of a pure "Class III" antiarrhythmic drug (GLG-V-13) inconscious rabbits. Both compounds decreased heart rate dose-dependently. Mean arterial blood pressurewas not influenced by E-7229; however, GLG-V-13 produced a significant elevation on this parameter. Leftventricular end-diastolic pressure was gradually increased by E-7229, while GLG-V-13 induced moreconsiderable elevation on that at intermediate doses. QT and QTcb were lengthened by both compounds;however, higher doses of E-7229 resulted in shortening of the prolonged QT and QTcb.Ventricular effectiverefractory period (VERP) was significantly prolonged by either drug studied. Threshold doses to produceQT50%, QTmax, VERP50%, and VERPmax were significantly higher for E-7229 compared with GLG-V-13.Significantly higher doses were required for E-7229 to induce arrhythmias. The safety ratio was comparablefor both of the compounds. E-7229 can exert multiple actions on cardiac ion channels with minimalinfluence on hemodynamic parameters and reduced proarrhytmic profile in our preclinical model.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
cardiac arrhythmias
preclinical drug development
cardiovascular safety
preclinical model
Megjelenés:Drug Developmet Research. - 74 : 3 (2013), p. 173-185. -
További szerzők:Németh József (1954-) (vegyész, analitikus) Sári Réka (farmakológus) Di, Yin Kovács Anikó Szénási Gábor Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Peitl Barna (1972-) (orvos, farmakológus)
Pályázati támogatás:75965
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Internet cím:DOI
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