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1.

001-es BibID:BIBFORM002994
Első szerző:Aime, Silvio
Cím:Paramagnetic contrast agents / Aime, Silvio, Baranyai, Zsolt, Gianolio, Eliana, Terreno, Enzo
Dátum:2007
Megjegyzések:A review on paramagnetic contrast agents used in magnetic resonance imaging (MRI). The routes for improving the relaxivity of Gd-chelates are discussed, along with macromol. paramagnetic systems, targeting of human serum albumin, covalent macromol. paramagnetic systems, contrast agents sensitive to redox potential, concn.-independent responsive probes, and effects on the relaxivity when going from aq. solns. to cellular systems.
Tárgyszavak:Természettudományok Kémiai tudományok könyvfejezet
Blood serum
Human
Albumins Role: BSU, BIOL
Paramagnetism
Imaging agents
Liver
review
magnetic resonance imaging paramagnetic contrast agent
Megjelenés:Molecular and Cellular MR Imaging / ed. Modo, Michael M. J., Bulte, Jeff W. M. - p. 37-58.
További szerzők:Baranyai Zsolt (1977-) (vegyész) Gianolio, Eliana Terreno, Enzo Modo, Michael M. J. Bulte, Jeff W. M.
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2.

001-es BibID:BIBFORM081486
Első szerző:Baranyai Zsolt (vegyész)
Cím:The Role of Equilibrium and Kinetic Properties in the Dissociation of Gd[DTPA-bis(methylamide)] (Omniscan) at near to Physiological Conditions / Zsolt Baranyai, Ernő Brücher, Fulvio Uggeri, Alessandro Maiocchi, Imre Tóth, Melinda Andrási, Attila Gáspár, László Zékány, Silvio Aime
Dátum:2015
ISSN:0947-6539 1521-3765
Megjegyzések:[Gd(DTPA?BMA)] is the principal constituent of Omniscan, a magnetic resonance imaging (MRI) contrast agent. In body fluids, endogenous ions (Zn2+, Cu2+, and Ca2+) may displace the Gd3+. To assess the extent of displacement at equilibrium, the stability constants of DTPA?BMA3? complexes of Gd3+, Ca2+, Zn2+, and Cu2+ have been determined at 37?°C in 0.15?M NaCl. The order of these stability constants is as follows: GdL?CuL>ZnL?CaL. Applying a simplified blood plasma model, the extent of dissociation of Omniscan (0.35?mM [Gd(DTPA?BMA)]) was found to be 17?% by the formation of Gd(PO4), [Zn(DTPA?BMA)]? (2.4?%), [Cu(DTPA?BMA)]? (0.2?%), and [Ca(DTPA?BMA)]? (17.7?%). By capillary electrophoresis, the formation of [Ca(DTPA?BMA)]? has been detected in human serum spiked with [Gd(DTPA?BMA)] (2.0?mM) at pH?7.4. Transmetallation reactions between [Gd(DTPA?BMA)] and Cu2+ at 37?°C in the presence of citrate, phosphate, and bicarbonate ions occur by dissociation of the complex assisted by the endogenous ligands. At physiological concentrations of citrate, phosphate, and bicarbonate ions, the half?life of dissociation of [Gd(DTPA?BMA)] was calculated to be 9.3?h at pH?7.4. Considering the rates of distribution and dissociation of [Gd(DTPA?BMA)] in the extracellular space of the body, an open two?compartment model has been developed, which allows prediction of the extent of dissociation of the GdIII complex in body fluids depending on the rate of elimination of the contrast agent.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
complex stability
gadolinium
kinetics
magnetic
resonance imaging
reaction mechanisms
Megjelenés:Chemistry-A European Journal. - 21 : 12 (2015), p. 4789-4799. -
További szerzők:Brücher Ernő (1935-) (vegyész) Uggeri, Fulvio Maiocchi, Alessandro (vegyész) Tóth Imre (1950-) (vegyész) Andrási Melinda (1979-) (gyógyszerész) Gáspár Attila (1970-) (vegyész, kémikus) Zékány László (1948-) (vegyész) Aime, Silvio
Pályázati támogatás:TÁMOP 4.2.4. A/2-11-1-2012-0001
TÁMOP
A2-MZPD-12-0038
Egyéb
OTKA K109029
OTKA
OTKA K111932
OTKA
OTKA PD83071
OTKA
TÁMOP-4.2.2 A-11/1/KONV-2012-0043
TÁMOP
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DOI
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3.

001-es BibID:BIBFORM047932
Első szerző:Baranyai Zsolt (vegyész)
Cím:Equilibrium, Kinetic and Structural Studies of AAZTA Complexes with Ga3+, In3+ and Cu2+ / Zsolt Baranyai, Fulvio Uggeri, Alessandro Maiocchi, Giovanni B. Giovenzana, Camilla Cavallotti, Anett Takács, Imre Tóth, István Bányai, Attila Bényei, Ernő Brücher, Silvio Aime
Dátum:2013
Megjegyzések:A detailed study of the structures, thermodynamic stabilities and kinetics of the dissociation of Ga3+, In3+ and Cu2+ complexes formed with the heptadentate ligand AAZTA is reported. The stability constants (logKML) of the AAZTA complexes of Ga3+, In3+ and Cu2+ are 22.18, 29.58 and 22.27, respectively, which suggests that the seven-membered-ring skeleton is suited to the accommodation of these metal ions. The solid-state structure of Cu(H2AAZTA)]?H2O shows a distorted octahedral coordination. The equatorial coordination sites of Cu2+ are occupied by one of the ring N atoms, a water O atom, one of the carboxylate O atoms and the N atom of the iminodiacetate moiety. The other ring N atom and thecarboxylate O atom of the iminodiacetate moiety coordinate to the Cu2+ in the axial positions. In the pH range 4.5?8.5, Ga3+ is present in the form of the highly stable [Ga(AAZTA)OH]2? (log ?GaLH?1 = 17.69) The exchange reactions of [Ga(AAZTA)OH]2? with Cu2+ and transferrin are very slow and mainly occur through the spontaneous dissociation of the complex close to physiological conditions. The half-life for the dissociation of [Ga(AAZTA)OH]2? is t1/2 = 23 h at pH = 7.5 and 25 ?C in 0.025 M NaHCO3 and 0.15 M NaCl. The high conditional stability, fast formation and sufficiently slow dissociation of [Ga(AAZTA)OH]2? represent promising properties for the complexation and diagnostic applications of radioactive Ga isotopes.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Gallium
Indium
Copper
Complexation
Thermodynamics
Kinetics
Radiopharmaceuticals
Imaging agents
Molekulatudomány
Doktori iskola
Megjelenés:European Journal Of Inorganic Chemistry. - 2013 : 1 (2013), p. 147-162. -
További szerzők:Uggeri, Fulvio Maiocchi, Alessandro (vegyész) Giovenzana, Giovanni Battista Cavallotti, Camilla Takács Anett Tóth Imre (1950-) (vegyész) Bányai István (1953-) (vegyész) Bényei Attila (1962-) (vegyész) Brücher Ernő (1935-) (vegyész) Aime, Silvio
Pályázati támogatás:K-84291
OTKA
TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
Bimodális kontrasztanyagok tervezése, előállítása és komplexeik fizikai-kémiai tulajdonságaik jellemzése
TÁMOP-4.2.2/B-10/1-2010-0024
TÁMOP
Kémiai Tudományok Doktori Iskola
EU COST (TD1004) "Theragnostics Imaging and Therapy" Action Program.
Egyéb
HU11MO2-TET_10-1-2011-0202
Egyéb
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4.

001-es BibID:BIBFORM008188
Első szerző:Baranyai Zsolt (vegyész)
Cím:Equilibrium and kinetic properties of the lanthanoids(III) and varioous divalent metal complexes of the heptadentate ligand AAZTA / Zsolt Baranyai, Fulvio Uggeri, Giovanni B. Giovenzana, Attila Bényei, Ernő Brücher, Silvio Aime
Dátum:2009
Megjegyzések:The heptadentate ligand 1,4-bis(hydroxycarbonylmethyl)-6-[bis(hy-droxycarbonylmethyl)]amino-6-methyl-perhydro-1,4-diazepine (AAZTA) and its derivatives were recently reported to give stable complexes with Gd3+ with superior efficiency as MRI contrast agents. Nevertheless, only preliminary data are available on the coordination behavior of this interesting ligand. In this work, thermodynamic and kinetic stability data are determined for the formation of complexes with AAZTA and the lanthanoid metal ions, and other divalent metal ions of interest for this application. The AAZTA ligand binds the lanthanoid ions with logKML values of 17.53-21.85 with its affinity steadily increasing from La3+ to Lu3+, suggesting that the seven-membered skeleton is better suited to accommodate smaller metal ions. Even though the denticity is lower, the stability of the heavier lanthanoid complexes is comparable to those of the classical ligand diethylene-triaminepentaacetic acid (DTPA). The transmetalation reactions of [Gd-(AAZTA)] with Cu2+ and Eu3+ predominantly occur through proton-assisted dissociation of the complex. The role of the direct attack of Cu2+ or Eu3+ in the exchange reactions is limited, although the formation of dinuclear complexes decreases the proton-assisted dissociation. Near physiological conditions, [Gd(AAZTA)] is significantly more inert than [Gd(DTPA)]2-, allowing its potentially safe use as contrast agent in magnetic resonance imaging.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
kinetics
lanthanides
Megjelenés:Chemistry-A European Journal. - 15 : 7 (2009), p. 1691-1705. -
További szerzők:Uggeri, Fulvio Giovenzana, Giovanni Battista Bényei Attila (1962-) (vegyész) Brücher Ernő (1935-) (vegyész) Aime, Silvio
Internet cím:DOI
elektronikus változat
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5.

001-es BibID:BIBFORM003002
Első szerző:Baranyai Zsolt (vegyész)
Cím:The effects of intramolecular H-bond formation on the stability constant and water exchange rate of the Gd(III)-diethylenetriamine-N'-(3-amino-1,1-propylenephosphonic)-N,N,N'',N''-tetraacetate complex / Zsolt Baranyai, Eliana Gianolio, Kondareddiar Ramalingam, Rolf Swenson, Ramachandran Ranganathan, E. Brücher, Silvio Aime
Dátum:2007
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Contrast Media & Molecular Imaging. - 2 : 2 (2007), p. 94-102. -
További szerzők:Gianolio, Eliana Ramalingam, Kondareddiar Swenson, Rolf Ranganathan, Ramachandran Brücher Ernő (1935-) (vegyész) Aime, Silvio
Internet cím:elektronikus változat
elektronikus változat
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6.

001-es BibID:BIBFORM102964
035-os BibID:(Wos)000461868900028 (Scopus)85061908762
Első szerző:Ferrauto, Giuseppe
Cím:Modifying LnHPDO3A Chelates for Improved and CEST MRI Applications / Ferrauto Giuseppe, Delli Castelli Daniela, Leone Loredana, Botta Mauro, Aime Silvio, Baranyai Zsolt, Tei Lorenzo
Dátum:2019
ISSN:0947-6539 1521-3765
Megjegyzések:The new ligand HPDO3MA [(R,R,R,R)-10-(2-hydroxypropyl)-alpha,alpha,alpha-trimethyl-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid] was designed to combine and optimize the chemical properties of the macrocyclic ligands HPDO3A and DOTMA. The presence of the methyl groups on the acetic pendant arms of HPDO3A is expected to rigidify the structure of the ligand and favor an increase of the kinetic inertness of the Ln complexes. H-1 NMR spectra of Eu(HPDO3MA) displayed the presence of two pairs of diastereoisomers: SAP (square antiprismatic) and TSAP (twisted square antiprismatic) isomers (56 and 44 %, respectively). In addition, H-1 and O-17 relaxometric NMR studies of Gd(HPDO3MA) showed approximately a 10 % increase in relaxivity and a faster water exchange rate with respect to Gd(HPDO3A). Moreover, a detailed chemical exchange saturation transfer (CEST) characterization of Yb(HPDO3MA) displayed a sensitivity about two times larger than that of Yb(HPDO3A) both in phantom and in cell labeling experiments. Finally, the kinetic inertness of Yb(HPDO3MA) was measured to be twice as high as that of Yb(HPDO3A), with a dissociation half-life at physiological pH of about 2500 years.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Chemistry-A European Journal. - 25 : 16 (2019), p. 4184-4193. -
További szerzők:Castelli, Daniela Delli Leone, Loredana Botta, Mauro Aime, Silvio Tei, Lorenzo Baranyai Zsolt (1977-) (vegyész)
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7.

001-es BibID:BIBFORM006196
Első szerző:Giovenzana, Giovanni Battista
Cím:NorDATA : an original ligand based on the norbornane skeleton : synthesis and thermodynamic characterization of metal complexes / Giovanni B. Giovenzana, Zsolt Baranyai, Silvio Aime, Camilla Cavallotti, Daniela Imperio, Giovanni Palmisano
Dátum:2008
ISSN:0277-5387
Megjegyzések:An original diaminotetracarboxylic ligand based on the rigid bicyclic norbornane skeleton was synthesized in four steps. The stability of its metal complexes was measured in water by potentiometric titrn. and discussed.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Polyaminocarboxylic ligand
Norbornane
Metal complexes
Protonation constants
Stability constants
Megjelenés:Polyhedron. - 27 : 18 (2008), p. 3683-3687. -
További szerzők:Baranyai Zsolt (1977-) (vegyész) Aime, Silvio Cavallotti, Camilla Imperio, Daniela Palmisano, Giovanni
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DOI
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8.

001-es BibID:BIBFORM006198
Első szerző:Kálmán Ferenc K. (vegyész)
Cím:Synthesis, potentiometric, kinetic, and NMR studies of 1,4,7,10-tetraazacyclododecane-1,7-bis(acetic acid)-4,10-bis(methylenephosphonic acid) (DO2A2P) and its complexes with Ca(II), Cu(II), Zn(II) and lanthanide(III) ions / Kalman, F. K., Baranyai, Z., Toth, I., Banyai, I., Kiraly, R., Brucher, E., Aime, S., Sun, X., Sherry, A. D., Kovacs, Z.
Dátum:2008
ISSN:0020-1669
Megjegyzések:A cyclen-based ligand containing trans-acetate and trans-methylenephosphonate pendant groups, H(6)DO2A2P, was synthesized and its protonation constants (12.6, 11.43, 5.95, 6.15, 2.88, and 2.77) were determined by pH-potentiometry and H-1 NMR spectroscopy. The first two protonations were shown to occur at the two macrocyclic ring N-CH2-PO32- nitrogens while the third and fourth protonations occur at the two phosphonate groups. In parallel with protonation of the two -PO32- groups, the protons from the NH+-CH2-PO32- are transferred to the N-CH2-COO- nitrogens. The stability constants of the Ca2+, Cu2+, and Zn2+ (ML, MHL, MH2L, and M2L) complexes were determined by direct pH-potentiometry. Lanthanide(III) ions (Ln(3+)) form similar species, but the formation of complexes is slow; so, "out-of-cell" pH-potentiometry (La3+, Eu3+, Gd3+, Y3+) and competitive spectrophotometry with Cu(II) ion (Lu3+) were used to determine the stability constants. By comparing the log K-ML values with those of the corresponding DOTA (H(4)DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and DOTP (H8DOTP = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylenephosphonic acid) complexes, the order DOTA < DO2A2P < DOTP was found for all the metal ion complexes examined here with the exception of the Ca2+ complexes, for which the order is reversed. The relaxivity of Gd(DO2A2P) decreases between pH 2 and 7 but remains constant in the pH range of 7 < pH < 12 (r(1) = 3.6 mM(-1) s(-1)). The linewiths of the O-17 NMR signals of water in the absence and presence of Gd(DO2A2P) (at pH = 3.45 and 8.5) between 274 and 350 K are practically the same, characteristic of a q = 0 complex. Detailed kinetic studies of the Ce3+ and Gd3+ complexes with DO2A2P showed that complex formation is slow and involves a high stability diprotonated intermediate Ln(H(2)DO2A2P)*. Rearrangement of the diprotonated intermediate into the final complex is an OH- assisted process but, unlike formation of Ln(DOTA) complexes, rearrangement of Ln(H(2)DO2A2P)* also takes place spontaneously likely as a result of transfer of one of the protons from a ring nitrogen to a phosphonate group. The order of the OH- assisted formation rates of complexes is DOTA > DO2A2P > DOTP while the order of the proton assisted dissociation rates of the Gd3+ complexes is reversed, DOTP > DO2A2P > DOTA. H-1 and C-13 NMR spectra of Eu(DO2A2P) and Lu(DO2A2P) were assigned using two-dimensional correlation spectroscopy (2D COSY), heteronuclear multiple quantum coherence (HMQC), heteronuclear chemical shift correlation (HETCOR), and exchange spectroscopy (EXSY) NMR methods. Two sets of H-1 NMR signals were observed for Eu(DO2A2P) characteristic of the presence of two coordination isomers in solution, a twisted square antiprism (TSAP) and a square antiprism (SAP), in the ratio of 93% and 7%, respectively. Line shape analysis of the H-1 NMR spectra of Lu(DO2A2P) gave lower activation parameters compared to La(DOTP) for interconversion between coordination isomers. This indicates that the Ln(DO2A2P) complexes are less rigid probably due to the different size and spatial requireents of the carboxylate and phosphonate groups.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Inorganic Chemistry. - 47 : 9 (2008), p. 3851-3862. -
További szerzők:Baranyai Zsolt (1977-) (vegyész) Tóth Imre (1950-) (vegyész) Bányai István (1953-) (vegyész) Király Róbert Brücher Ernő (1935-) (vegyész) Aime, Silvio Sun, Xiankai Sherry, A. Dean Kovács Zoltán
Internet cím:elektronikus változat
Borító:

9.

001-es BibID:BIBFORM120527
035-os BibID:(Scopus)85098230327 (WoS)000602621300001
Első szerző:Kock, Flávio Vinicius Crizóstomo
Cím:[Gd(AAZTA)]- Derivatives with n-Alkyl Acid Side Chains Show Improved Properties for Their Application as MRI Contrast Agents** / Flávio Vinicius Crizóstomo Kock, Attila Forgács, Nicol Guidolin, Rachele Stefania, Adrienn V#gner, Eliana Gianolio, Silvio Aime, Zsolt Baranyai
Dátum:2021
ISSN:0947-6539 1521-3765
Megjegyzések:Herein, the synthesis and an extensive characterization of two novel Gd(AAZTA) (AAZTA=6-amino-6-methylperhydro-1,4-diazepine tetra acetic acid) derivatives functionalized with short (C-2 and C-4) n-alkyl acid functions are reported. The carboxylate functionality is the site for further conjugations for the design of more specific contrast agents (CAs). Interestingly, it has been found that the synthesized complexes display enhanced properties for use as MRI contrast agents on their own. The stability constants determined by using potentiometric titration and UV/Vis spectrophotometry were slightly higher than the one reported for the parent Gd(AAZTA) complex. This observation might be accounted for by the larger sigma-electron donation of the acyl substituents with respect to the one provided by the methyl group in the parent complex. As far as concerns the kinetic stability, transmetallation experiments with endogenous ions (e.g. Cu2+) implied that the Gd3+ ions present in these Gd(AAZTA) derivatives show somewhat smaller susceptibility to chemical exchange towards these ions at 25 degrees C, close to the physiological condition. The H-1 NMR spectra of the complexes with Eu-III and Yb-III displayed a set of signals consistent with half the number of methylene protons present on each ligand. The number of resonances was invariant over a large range of temperatures, suggesting the occurrence of a fast interconversion between structural isomers. The relaxivity values (298 K, 20 MHz) were consistent with q=2 being equal to 8.8 mm(-1) s(-1) for the C-2 derivative and 9.4 mm(-1) s(-1) for the C-4 one, that is, sensibly larger than the one reported for Gd(AAZTA) (7.1 mm(-1) s(-1)). Variable-temperature (VT)-T-2 O-17 NMR measurements showed, for both complexes, the presence of two populations of coordinated water molecules, one in fast and one in slow exchange with the bulk water. As the high-resolution H-1 NMR spectra of the analogs with Eu-III and Yb-III did not show the occurrence of distinct isomers (as frequently observed in other macrocyclic lanthanide(III)-containing complexes), we surmised the presence of two fast-interconverting isomers in solution. The analysis of the O-17 NMR VT-T-2 profiles versus temperature allowed their relative molar fraction to be established as 35 % for the isomer with the fast exchanging water and 65 % for the isomer with the water molecules in slower exchange. Finally, H-1 NMRD profiles over an extended range of applied magnetic field strengths have been satisfactory fitted on the basis of the occurrence of the two interconverting species.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
contrast agents
kinetics
lanthanides
ligands
MRI
relaxation
thermodynamic
Megjelenés:Chemistry-A European Journal. - 27 : 5 (2021), p. 1849-1859. -
További szerzők:Forgács Attila (1988-) (vegyész) Guidolin, Nicol Stefania, Rachele Vágner Adrienn Gianolio, Eliana Aime, Silvio Baranyai Zsolt (1977-) (vegyész)
Pályázati támogatás:GINOP-2.3.2-15-2016-00008
GINOP
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10.

001-es BibID:BIBFORM110923
035-os BibID:(WoS)000631626000011 (Scopus)85103100952
Első szerző:Lattuada, Luciano
Cím:Enhanced relaxivity of Gd III-complexes with HP-DO3A-like ligands upon the activation of the intramolecular catalysis of the prototropic exchange / Lattuada, Luciano; Horváth, Dávid; Colombo Serra, Sonia; Fringuello Mingo, Alberto; Minazzi, Paolo; Bényei, Attila; Forgács, Attila; Fedeli, Franco; Gianolio, Eliana; Aime, Silvio; Giovenzana, Giovanni B.; Baranyai, Zsolt
Dátum:2021
ISSN:2052-1553
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Inorganic Chemistry Frontiers. - 8 : 6 (2021), p. 1500-1510. -
További szerzők:Horváth Dávid (1991-) (vegyész) Colombo Serra, Sonia Fringuello Mingo, Alberto Minazzi, Paolo Bényei Attila (1962-) (vegyész) Forgács Attila (1988-) (vegyész) Fedeli, Franco Gianolio, Eliana Aime, Silvio Giovenzana, Giovanni Battista Baranyai Zsolt (1977-) (vegyész)
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11.

001-es BibID:BIBFORM068358
Első szerző:Nagy Gábor (radiokémikus, vegyész)
Cím:AAZTA : an Ideal Chelating Agent for the Development of 44Sc PET Imaging Agents / Nagy Gábor, Szikra Dezső, Trencsényi György, Fekete Anikó, Garai Ildikó, Giani Arianna M., Negri Roberto, Masciocchi Norberto, Maiocchi Alessandro, Uggeri Fulvio, Tóth Imre, Aime Silvio, Giovenzana Giovanni B., Baranyai Zsolt
Dátum:2017
ISSN:1433-7851
Megjegyzések:Unprecedented fast and efficient complexation of ScIII was demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the 44Sc(AAZTA)? chelate and conjugated biomolecules thereof is further shown by in?vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.
Tárgyszavak:Orvostudományok Klinikai orvostudományok kutatási jelentés
AAZTA
labeling
44Sc
Sc-44
scandium
Megjelenés:Angewandte Chemie-International Edition. - 56 : 8 (2017), p. 2118-2122. -
További szerzők:Szikra Dezső Péter (1983-) (vegyész) Trencsényi György (1978-) (biológus, biokémikus, molekuláris biológus) Fekete Anikó (1973-) (vegyész) Garai Ildikó (1966-) (radiológus) Giani, Arianna Maria Negri, Roberto Masciocchi, Norberto Maiocchi, Alessandro (vegyész) Uggeri, Fulvio Tóth Imre (1950-) (vegyész) Aime, Silvio Giovenzana, Giovanni Battista Baranyai Zsolt (1977-) (vegyész)
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12.

001-es BibID:BIBFORM084248
Első szerző:Napolitano, Roberta
Cím:Synthesis and Relaxometric Characterization of a MRI Gd-Based Probe Responsive to Glutamic Acid Decarboxylase Enzymatic Activity / Roberta Napolitano, Giorgio Pariani, Franco Fedeli, Zsolt Baranyai, Markus Aswendt, Silvio Aime, Eliana Gianolio
Dátum:2013
ISSN:0022-2623 1520-4804
Megjegyzések:Novel contrast agent based systems, which selectively visualize specific cells, e.g., neurons in the brain, would be of substantial importance for the fast developing field of molecular magnetic resonance imaging (MRI). We report here the synthesis and in vitro validation of a Gd(III)-based contrast agent designed to act as an MRI responsive probe for imaging the activity of the enzyme glutamic acid decarboxylase (GAD) present in neurons. Upon the action of the enzyme, the Gd(III) complex increases its hydration sphere and takes on a residual positive charge that promotes its binding to endogenous macromolecules. Both effects contribute in a synergic way to generate a marked relaxation enhancement, which directly reports enzyme activity and will allow activity detection of GAD positive cells in vitro and in vivo selectively.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
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Megjelenés:Journal Of Medicinal Chemistry. - 56 : 6 (2013), p. 2466-2477. -
További szerzők:Pariani, Giorgio Fedeli, Franco Baranyai Zsolt (1977-) (vegyész) Aswendt, Markus Aime, Silvio Gianolio, Eliana
Pályázati támogatás:ENCITE EU-FP7 HEALTH-F5-2008-201842
Egyéb
MIUR (Project PRIN 2009235JB7)
Egyéb
Italian Consortium CIRCMSB
Egyéb
Volkswagen Foundation (Grant I/83 443)
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