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001-es BibID:BIBFORM059038
Első szerző:Józsa Tamás (gyermeksebész, urológus)
Cím:Morphological and microcirculatory evaluation of the rat testis after detorsion with or without a capsular release with a tunica vaginalis flap / Tamás Józsa, Zoltán Klárik, Ferenc Kiss, Enikő Tóth, Anita Mester, Zoltán Hargitai, Yi-Che Changchien, Magdalena Fossum, Norbert Németh
Dátum:2016
ISSN:1008-682X
Megjegyzések:Testicular torsion may lead to serious ischemia, and the viability depends on the duration of torsion and the effect of ischemia-reperfusion. Testicular decompression and tunica vaginalis fl ap application technique were introduced in 2008 by Kutikov et al. We aimed to examine the impact of this method on the testicular microcirculation and hemorheological parameters in a rat model. Six adult rats underwent bilateral scrotal exploration. Intravaginal torsion of the testis was created by 720° rotation on both sides for 2 h. After detorsion, the right testes underwent tunica albuginea incision and tunica vaginalis fl ap application. Testicular microcirculation was monitored and hematological parameters, erythrocyte deformability, and aggregation were determined. Measurements were performed before and after torsion, directly after detorsion, on the 1st-2nd and 8th postoperative day. After the last sampling, testicles were removed to determine their volume for histological examinations. The microcirculatory parameters demonstrated slight differences between testicles. Apical zone of the left (nondecompressed) testicles had elevated compared to the middle zone (P < 0.05). On the 2nd and 8th day, the microcirculation of the testes normalized but not equally. The erythrocyte aggregation and deformability decreased by the 8th day. Both testicles underwent atrophy and epithelial necrosis, but the volume of the decompressed ones was lower (1.07 ± 0.08 vs 1.25 ± 0.31). Histologically, there was no signifi cant difference in epithelial damage score between decompressed and nondecompressed testes. In conclusion, 2-h ischemia led to alteration in testicular microcirculation, reduction in volume, changes in hemorheological parameters and serious epithelial necrosis both in decompressed and nondecompressed testicles without remarkable differences.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
ischemia
rat model
reperfusion
spermatic cord torsion
surgical fl aps
testicular compartment syndrome
testis
Megjelenés:Asian Journal Of Andrology. - 18 : 3 (2016), p. 462-466. -
További szerzők:Klárik Zoltán (1985-) Kiss Ferenc (1982-) (kutatóorvos) Tóth Enikő Mester Anita Hargitai Zoltán Chang Chien, Yi-Che (1975-) (pathológus) Fossum, Magdalena Németh Norbert (1975-) (kutatóorvos)
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