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001-es BibID:BIBFORM047985
Első szerző:Benyó Mátyás (urológus)
Cím:Present practice of thrombosis prophylaxis of radical prostatectomy in a European country - a Hungarian multicenter study / Matyas Benyo, Jolan Harsfalvi, Gyorgy Pfliegler, Zsuzsanna Molnar, Mihaly Muranyi, Tamas Jozsa, Tibor Flasko
Dátum:2014
ISSN:0042-1138
Megjegyzések:Venous thromboembolism is a possible fatal complication after pelvic surgery. There is a lack of trials assessing the effect of prophylactic measures in urology. The aim of the study was to evaluate the practice of thrombosis prophylaxis in a Central European country.A questionnaire of performed radical prostatectomies, way of thrombosis prophylaxis and number of experienced thrombotic events was posted to all Hungarian departments of urology.With a response rate of 59% 506 radical prostatectomies were reported. Low molecular weight heparin was administered by 100% of the departments. Graduated support stockings were applied by 37% of the patients. Early mobilization was the most common way of mechanic prophylaxis (57%). Thrombotic events were experienced in 1.4%, 0.2% was fatal.The thrombosis prophylaxis of patients undergoing radical prostatectomy is not unified. Due to the potential mortality of thrombotic complications it should be evaluated and prophylaxis should be recommended in urological guidelines.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Urologia Internationalis. - 92 : 3 (2014), p. 289-293. -
További szerzők:Hársfalvi Jolán (1949-) (klinikai biokémikus) Pfliegler György (1949-) (belgyógyász, hematológus, labor szakorvos) Molnár Zsuzsanna (1980-) (szülész-nőgyógyász, labor szakorvosjelölt, urológus) Murányi Mihály (1983-) (urológus) Józsa Tamás (1969-) (gyermeksebész, urológus) Flaskó Tibor (1960-) (urológus)
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001-es BibID:BIBFORM040065
Első szerző:Benyó Mátyás (urológus)
Cím:Follow-Up of Thrombin Generation after Prostate Cancer Surgery : Global Test for Increased Hypercoagulability / Matyas Benyo, Tibor Flasko, Zsuzsanna Molnar, Adrienne Kerenyi, Zoltan Batta, Tamas Jozsa, Jolan Harsfalvi
Dátum:2012
ISSN:1932-6203
Megjegyzések:Recent studies provided evidence that evaluation of thrombin generation identifies patients at thrombotic risk. Thrombin generation has a central role in hemorrhage control and vascular occlusion and its measurement provides new metrics of these processes providing sufficient evaluation of an individual's hemostatic competence and response to anticoagulant therapy. The objective of the study is to assess a new measure of hypercoagulability that predisposes to venous thromboembolism in the postoperative period after radical prostatectomy. Pre- (day-1) and postoperative (hour 1, day 6, month 1 and 10) blood samples of 24 patients were tested for plasma thrombin generation (peak thrombin), routine hematology and hemostasis. Patients received low molecular weight heparin for thromboprophylaxis. Peak thrombin levels were higher in patients compared to controls at baseline (p<0.001), and elevated further in the early postoperative period (p<0.001). Longer general anesthesia and high body mass index were associated with increased thrombin generation after surgery (p = 0.024 and p = 0.040). D dimer and fibrinogen levels were higher after radical prostatectomy (p = 0.001 and p<0.001). Conventional clotting tests remained within the reference range. Our study contributed to the cognition of the hypercoagulable state in cancer patients undergoing pelvic surgery and revealed the course of thrombin generation after radical prostatectomy. Whilst it is unsurprising that thrombin generation increases after tissue trauma, further evaluation of this condition during the postoperative period would lead urologists to an international and well-supported consensus regarding thromboprophylaxis in order to provide better clinical outcome. Considering the routine evaluation of procoagulant activity and extending prophylactic anticoagulant therapy accordingly may potentially prevent late thrombotic events.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Plos One. - 7 : 12 (2012), p. e51299. -
További szerzők:Flaskó Tibor (1960-) (urológus) Molnár Zsuzsanna (1980-) (szülész-nőgyógyász, labor szakorvosjelölt, urológus) Kerényi Adrienne (1970-) (laboratóriumi szakorvos) Batta Zoltán Józsa Tamás (1969-) (gyermeksebész, urológus) Hársfalvi Jolán (1949-) (klinikai biokémikus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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