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1.

001-es BibID:BIBFORM067463
Első szerző:Geninatti-Crich, Simonetta
Cím:Mn-loaded apoferritin: a highly sensitive MRI imaging probe for the detection and characterization of hepatocarcinoma lesions in a transgenic mouse model / Simonetta Geninatti Crich, Juan Carlos Cutrin, Stefania Lanzardo, Laura Conti, Ferenc K. Kálmán, Ibolya Szabó, Néstor R. Lago, Achille Iolascon, Silvio Aime
Dátum:2012
ISSN:1555-4309 1555-4317
Megjegyzések:Mn-Apo is a highly sensitive MRI contrast agent consisting of ca. 1000 manganese atoms entrapped in the inner cavity of apoferritin. Part of the metallic payload is in the form of Mn2+ ions that endow the nano-sized system with a very high relaxivity that can be exploited to detect hepatocellular carcinoma in mice. Cellular studies showed that Mn-Apo is readily taken up by normal hepatocytes via the ferritin transporting route. Conversely, hepatoma cells (HTC) displayed a markedly reduced ability to entrap Mn-Apo from the culture medium. The i.v. administration of Mn-Apo into C57BL/6?J mice resulted in a marked liver tissue hyperintensity in T1-weighted MR image?20?min after injection. When injected into HBV-tg transgenic mice that spontaneously develop hepatocellular carcinoma (HCC), Mn-Apo allowed a clear delineation of healthy liver tissue and tumor lesions as hyperintense and hypointense T1-weighted MR images, respectively. Immunohistochemistry analysis correlated Mn-Apo cellular uptake to SCARA5 receptor expression. When the MRI contrast induced by Mn-Apo was compared with that induced by Gd?BOPTA (a commercial contrast agent known to enter mouse hepatocytes through organic anion transporters) it was found that only some of the lesions were detected by both agents while others could only be visualized by one of the two. These results suggest that Mn-Apo may be useful to detect otherwise invisible lesions and that the extent of its uptake directly reports the expression/regulation of SCARA5 receptors. Mn-Apo contrast-enhanced MR images may therefore contribute to improving HCC lesion detection and characterization.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
hepatocellular carcinoma
MRI
ferritin
molecular imaging
manganese
Megjelenés:Contrast Media and Molecular Imaging. - 7 : 3 (2012), p. 281-288. -
További szerzők:Cutrin, Juan Carlos (vegyész) Lanzardo, Stefania (vegyész) Kálmán Ferenc K. (1978-) (vegyész) Kálmán-Szabó Ibolya (1980-) (molekuláris biológus) Lago, Néstor R. (Biológus) Iolascon, Achille Aime, Silvio
Pályázati támogatás:PD-OTKA-83253
OTKA
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2.

001-es BibID:BIBFORM016465
Első szerző:Gianolio, Eliana
Cím:Improving the relaxivity by dimerizing Gd-AAZTA : Insights for enhancing the sensitivity of MRI contrast agents / Eliana Gianolio, Kondareddiar Ramalingam, Bo Song, Ferenc Kalman, Silvio Aime, Rolf Swenson
Dátum:2010
ISSN:1387-7003
Megjegyzések:The synthesis of a dimeric derivative of Gd-AAZTA is reported. It retains the basic properties of the parent complex (q = 2, high stability) and displays a relaxivity of 14.0 mM(-1) s(-1) at 20 MHz and 298 K. The outstanding relaxivity is the result of the increased molecular reorientational time and of the contribution arising from 4 to 5 water molecules in the second coordination sphere of the Gd(III) ions. (C) 2010 Elsevier B.V. All rights reserved.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Gadolinium chelate
MRI imaging
Relaxivity
water exchange
o-17 nmr
variable-temperature
complexes
relaxation
dynamics
Megjelenés:Inorganic Chemistry Communications. - 13 : 5 (2010), p. 663-665. -
További szerzők:Ramalingam, Kondareddiar Song, Bo Kálmán Ferenc K. (1978-) (vegyész) Aime, Silvio Swenson, Rolf
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3.

001-es BibID:BIBFORM016468
Első szerző:Kálmán Ferenc K. (vegyész)
Cím:Reduction/Dissolution of a beta-MnOOH Nanophase in the Ferritin Cavity To Yield a Highly Sensitive, Biologically Compatible Magnetic Resonance Imaging Agent / Ferenc Krisztián Kálmán, Simonetta Geninatti-Crich, Silvio Aime
Dátum:2010
ISSN:1433-7851
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
contrast agents
imaging agents
magnetic resonance imaging
manganese
proteins
chelating-agents
mammalian ferritin
contrast agents
enhanced mri
iron release
horse spleen
gadolinium
apoferritin
nanoparticles
ethylenediaminetetraacetate
Megjelenés:Angewandte Chemie International Edition. - 49 : 3 (2010), p. 612-615. -
További szerzők:Geninatti-Crich, Simonetta Aime, Silvio
Internet cím:DOI
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4.

001-es BibID:BIBFORM006198
Első szerző:Kálmán Ferenc K. (vegyész)
Cím:Synthesis, potentiometric, kinetic, and NMR studies of 1,4,7,10-tetraazacyclododecane-1,7-bis(acetic acid)-4,10-bis(methylenephosphonic acid) (DO2A2P) and its complexes with Ca(II), Cu(II), Zn(II) and lanthanide(III) ions / Kalman, F. K., Baranyai, Z., Toth, I., Banyai, I., Kiraly, R., Brucher, E., Aime, S., Sun, X., Sherry, A. D., Kovacs, Z.
Dátum:2008
ISSN:0020-1669
Megjegyzések:A cyclen-based ligand containing trans-acetate and trans-methylenephosphonate pendant groups, H(6)DO2A2P, was synthesized and its protonation constants (12.6, 11.43, 5.95, 6.15, 2.88, and 2.77) were determined by pH-potentiometry and H-1 NMR spectroscopy. The first two protonations were shown to occur at the two macrocyclic ring N-CH2-PO32- nitrogens while the third and fourth protonations occur at the two phosphonate groups. In parallel with protonation of the two -PO32- groups, the protons from the NH+-CH2-PO32- are transferred to the N-CH2-COO- nitrogens. The stability constants of the Ca2+, Cu2+, and Zn2+ (ML, MHL, MH2L, and M2L) complexes were determined by direct pH-potentiometry. Lanthanide(III) ions (Ln(3+)) form similar species, but the formation of complexes is slow; so, "out-of-cell" pH-potentiometry (La3+, Eu3+, Gd3+, Y3+) and competitive spectrophotometry with Cu(II) ion (Lu3+) were used to determine the stability constants. By comparing the log K-ML values with those of the corresponding DOTA (H(4)DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and DOTP (H8DOTP = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylenephosphonic acid) complexes, the order DOTA < DO2A2P < DOTP was found for all the metal ion complexes examined here with the exception of the Ca2+ complexes, for which the order is reversed. The relaxivity of Gd(DO2A2P) decreases between pH 2 and 7 but remains constant in the pH range of 7 < pH < 12 (r(1) = 3.6 mM(-1) s(-1)). The linewiths of the O-17 NMR signals of water in the absence and presence of Gd(DO2A2P) (at pH = 3.45 and 8.5) between 274 and 350 K are practically the same, characteristic of a q = 0 complex. Detailed kinetic studies of the Ce3+ and Gd3+ complexes with DO2A2P showed that complex formation is slow and involves a high stability diprotonated intermediate Ln(H(2)DO2A2P)*. Rearrangement of the diprotonated intermediate into the final complex is an OH- assisted process but, unlike formation of Ln(DOTA) complexes, rearrangement of Ln(H(2)DO2A2P)* also takes place spontaneously likely as a result of transfer of one of the protons from a ring nitrogen to a phosphonate group. The order of the OH- assisted formation rates of complexes is DOTA > DO2A2P > DOTP while the order of the proton assisted dissociation rates of the Gd3+ complexes is reversed, DOTP > DO2A2P > DOTA. H-1 and C-13 NMR spectra of Eu(DO2A2P) and Lu(DO2A2P) were assigned using two-dimensional correlation spectroscopy (2D COSY), heteronuclear multiple quantum coherence (HMQC), heteronuclear chemical shift correlation (HETCOR), and exchange spectroscopy (EXSY) NMR methods. Two sets of H-1 NMR signals were observed for Eu(DO2A2P) characteristic of the presence of two coordination isomers in solution, a twisted square antiprism (TSAP) and a square antiprism (SAP), in the ratio of 93% and 7%, respectively. Line shape analysis of the H-1 NMR spectra of Lu(DO2A2P) gave lower activation parameters compared to La(DOTP) for interconversion between coordination isomers. This indicates that the Ln(DO2A2P) complexes are less rigid probably due to the different size and spatial requireents of the carboxylate and phosphonate groups.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Inorganic Chemistry. - 47 : 9 (2008), p. 3851-3862. -
További szerzők:Baranyai Zsolt (1977-) (vegyész) Tóth Imre (1950-) (vegyész) Bányai István (1953-) (vegyész) Király Róbert Brücher Ernő (1935-) (vegyész) Aime, Silvio Sun, Xiankai Sherry, A. Dean Kovács Zoltán
Internet cím:elektronikus változat
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5.

001-es BibID:BIBFORM109948
035-os BibID:(scopus)84857071101 (wos)000299741000019
Első szerző:Kálmán-Szabó Ibolya (molekuláris biológus)
Cím:Mn loaded apoferritin as an MRI sensor of melanin formation in melanoma cells / Szabó Ibolya, Crich Simonetta Geninatti, Alberti Diego, Kálmán Ferenc K., Aime Silvio
Dátum:2012
ISSN:1359-7345 1364-548X
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Chemical Communications. - 48 : 18 (2012), p. 2436-2438. -
További szerzők:Crich, Simonetta Geninatti Alberti, Diego Kálmán Ferenc K. (1978-) (vegyész) Aime, Silvio
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6.

001-es BibID:BIBFORM038094
Első szerző:Rojas-Quijano, Federico A.
Cím:Synthesis and Characterization of a Hypoxia-Sensitive MRI Probe / Federico A. Rojas-Quijano, Gyula Tircsó, Enikő Tircsóné Benyó, Zsolt Baranyai, Huan Tran Hoang, Ferenc K. Kálmán, Praveen K. Gulaka, Vikram D. Kodibagkar, Silvio Aime, Zoltán Kovács, A. Dean Sherry
Dátum:2012
ISSN:0947-6539
Megjegyzések:Tissue hypoxia occurs in pathologic conditions, such as cancer, ischemic heart disease and stroke when oxygen demand is greater than oxygen supply. An imaging method that can differentiate hypoxic versus normoxic tissue could have an immediate impact on therapy choices. In this work, the gadolinium complex of 1,4,7,10-tetraaza-1,4,7,10-tetraacetate (DOTA) with a 2-nitroimidazole attached to one carboxyl group via an amide linkage was prepared, characterized and tested as a hypoxia-sensitive MRI agent. A control complex, Gd(DO3A-monobutylamide), was also prepared in order to test whether the nitroimidazole sidechain alters either the water proton T1 relaxivity or the thermodynamic stability of the complex. The stabilities of these complexes were lower than thatof Gd(DOTA)- as expected for monoamide derivatives. The water proton T1 relaxivity (r1), bound water residence lifetime (tM) and rotational correlation time (tR) of both complexes was determined by relaxivity measurements, variable temperature 17O NMR spectroscopy and proton nuclear magnetic relaxation dispersion (NMRD) studies. The resulting parameters (r1=6.38 mM-1 s-1 at 20 MHz, tM=0.71 ms, tR=141 ps) determined for the nitroimidazole derivative closely parallel those of other Gd(DO3A-monoamide) complexes of similar molecular size. In vitro MR imaging experiments with 9L rat glioma cells maintained under nitrogen (hypoxic) versus oxygen (normoxic) gas showed that both agents enter cells but only the nitroimidazole derivative was trapped in cells maintained under N2 as evidenced by an approximately twofold decrease in T1 measured for hypoxic cells versus normoxic cells exposed to this agent. These results suggest that the nitroimidazole derivative might serve as a molecular reporter for discriminating hypoxic versus normoxic tissues by MRI.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Molekulatudomány
Megjelenés:Chemistry-A European Journal. - 18 : 31 (2012), p. 9669-9676. -
További szerzők:Tircsó Gyula (1977-) (vegyész, kémia tanár) Tircsóné Benyó Enikő (1977-) (vegyész, kémia tanár) Baranyai Zsolt (1977-) (vegyész) Tran-Hoang, Huan Kálmán Ferenc K. (1978-) (vegyész) Gulaka, Praveen K. Kodibagkar, Vikram D. Aime, Silvio Kovács Zoltán (1963-) (vegyész, angol szakfordító) Sherry, A. Dean
Pályázati támogatás:TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
Bimodális kontrasztanyagok tervezése, előállítása és komplexeik fizikai-kémiai tulajdonságaik jellemzése
TÁMOP-4.2.2./B-10/1-2010-0024
TÁMOP
K84291
OTKA
PD83253
OTKA
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7.

001-es BibID:BIBFORM010537
Első szerző:Rojas-Quijano, Federico A.
Cím:Lanthanide(III) Complexes of Tris(amide) PCTA Derivatives as Potential Bimodal Magnetic Resonance and Optical Imaging Agents / Federico A. Rojas-Quijano, Enikő Tircsóné Benyó, Gyula Tircsó, Ferenc K. Kálmán, Zsolt Baranyai, Silvio Aime, A. Dean Sherry, Zoltán Kovács
Dátum:2009
ISSN:0947-6539
Megjegyzések:Lanthanide complexes of two tris(amide) derivatives of PCTA were synthesized and characterized. The relaxometric and luminescence properties of their lanthanide complexes were investigated as bimodal magnetic resonance (MR) and optical imaging agents. Luminescence studies show that one of the Tb-III complexes dimerizes in solution at low millimolar concentrations, whereas the other may have a higher than expected coordination number in solution. The corresponding Gd-III complexes display unusually high T-1 relaxivities and enhanced kinetic inertness compared to GdPCTA. These features suggest that these new chelates may be suitable for in vivo applications. The fast water-exchange rates observed for these complexes make them unsuitable as paramagnetic chemical exchange saturation transfer (PAR-ACEST) agents.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Chemistry-a European Journal. - 15 : 47 (2009), p. 13188-13200. -
További szerzők:Tircsóné Benyó Enikő (1977-) (vegyész, kémia tanár) Tircsó Gyula (1977-) (vegyész, kémia tanár) Kálmán Ferenc K. (1978-) (vegyész) Baranyai Zsolt (1977-) (vegyész) Aime, Silvio Sherry, A. Dean Kovács Zoltán
Internet cím:DOI
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8.

001-es BibID:BIBFORM067452
Első szerző:Szabó Ibolya (molekuláris biológus)
Cím:Mn loaded apoferritin as an MRI sensor of melanin formation in melanoma cells / Ibolya Szabó, Simonetta Geninatti Crich, Diego Alberti, Ferenc K. Kálmán, Silvio Aime
Dátum:2012
ISSN:1359-7345
Megjegyzések:Mn(III)-loaded apoferritin is promptly reduced to Mn(II)?apoferritin by the oxidation of L-DOPA to melanin. The process is nicely witnessed by a marked relaxation enhancement of water proton relaxation rate that has been detected both in cultured melanoma cells and in tumor animal models.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Mn loaded apoferritin
melanin
MRI sensor
Megjelenés:Chemical Communications 48 (2012), p. 2436-2438. -
További szerzők:Geninatti-Crich, Simonetta Alberti, Diego Kálmán Ferenc K. (1978-) (vegyész) Aime, Silvio
Pályázati támogatás:FP7-HEALTH-2007-A
Egyéb
OTKA-PD-83253
OTKA
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