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001-es BibID:	BIBFORM067446
Első szerző:	Woods, Mark
Cím:	Synthesis, relaxometric and photophysical properties of a new pH-responsive MRI contrast agent : The effect of other ligating groups on dissociation of a p-nitrophenolic pendant arm / Mark Woods, Garry E. Kiefer, Simon Bott, Aminta Castillo-Muzquiz, Carrie Eshelbrenner, Lydie Michaudet, Kenneth McMillan, Siva D. K. Mudigunda, Doug Ogrin, Gyula Tircsó, Shanrong Zhang, Piyu Zhao, A. Dean Sherry
Dátum:	2004
ISSN:	0002-7863
Megjegyzések:	Two gadolinium(III) chelates, GdNP-DO3A (1-methlyene-(p-NitroPhenol)-1,4,7,10-tetraazacycloDOdecane-4,7,10-triAcetate) and GdNP-DO3AM (1-methlyene(p-NitroPhenol)-1,4,7,10-tetraazacycloDOdecane-4,7,10-triacetAMide), containing a single nitrophenolic pendant arm plus either three acetate or three amide pendant arms were synthesized and characterized. The properties of the gadolinium, terbium, and dysprosium complexes of these ligands were examined as a function of pH. The extent and mechanism of the changes in water relaxivity with pH of each gadolinium complex was found to differ substantially for the two complexes. The water relaxivity of Gd(NP-DO3A) increases from 4.1 mM-1 s-1 at pH 9 to 7.0 mM-1 s-1 at pH 5 as a result of acid-catalyzed dissociation of the nitrophenol from the lanthanide. The nitrophenol group in Gd(NP-DO3AM) does not dissociate from the metal center even at pH 5; therefore, the very modest increase in relaxivity in this complex must be ascribed to an increase in prototropic exchange rate of the bound water and/or phenolic protons.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban pH-Responsive MRI Contrast Agent gadolinium Synthesis Relaxometric Photophysical Properties
Megjelenés:	Journal of the American Chemical Society 126 : 30 (2004), p. 9248-9256. -
További szerzők:	Kiefer, Garry E. Bott, Simon G. Castillo-Muzquiz, Aminta Eshelbrenner, Carrie Michaudet, Lydie McMillan, Kenneth Mudigunda, Siva D. K. Ogrin, Doug Tircsó Gyula (1977-) (vegyész, kémia tanár) Zhang, Shanrong Zhao, Piyu Sherry, A. Dean
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