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001-es BibID:BIBFORM002765
Első szerző:Petrovski, Goran (orvos)
Cím:Clearance of dying autophagic cells of different origin by professional and non-professional phagocytes / Petrovski G., Zahuczky G., Katona K., Vereb G., Martinet W., Nemes Z., Bursch W., Fesus L.
Dátum:2007
Megjegyzések:MCF-7 cells undergo autophagic death upon tamoxifen treatment. Plated on non-adhesive substratum these cells died by anoikis while inducing autophagy as revealed by monodansylcadaverine staining, elevated light-chain-3 expression and electron microscopy. Both de novo and anoikis-derived autophagic dying cells were engulfed by human macrophages and MCF-7 cells. Inhibition of autophagy by 3-methyladenine abolished engulfment of cells dying through de novo autophagy, but not those dying through anoikis. Blocking exposure of phosphatidylserine (PS) on both dying cell types inhibited phagocytosis by MCF-7 but not by macrophages. Gene expression profiling showed that though both types of phagocytes expressed full repertoire of the PS recognition and signaling pathway, macrophages could evolve during engulfment of de novo autophagic cells the potential of calreticulin-mediated processes as well. Our data suggest that cells dying through autophagy and those committing anoikis with autophagy may engage in overlapping but distinct sets of clearance mechanisms in professional and non-professional phagocytes
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Apoptosis
Biophysics
Cells
Gene Expression
Human
Hungary
Macrophages
Microscopy
Phagocytosis
Research
Support
Megjelenés:Cell Death Differentiation. - 14 : 6 (2007), p. 1117-1128. -
További szerzők:Zahuczky Gábor (1975-) (molekuláris biológus, biokémikus, vegyész) Katona Klára (1976-) Vereb György (1965-) (biofizikus, orvos) Martinet, Wim Nemes Z. Bursch, Wilfried Fésüs László (1947-) (orvos biokémikus)
Internet cím:DOI
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