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001-es BibID:	BIBFORM015664
Első szerző:	Barok Márk (biofizikus)
Cím:	Characterization of a novel, trastuzumab resistant human breast cancer cell line / Barok Mark, Balazs Margit, Lazar Viktoria, Rakosy Zsuzsa, Toth Eniko, Treszl Andrea, Vereb Gyorgy, Colbern G. T., Park J. W., Szollosi Janos
Dátum:	2010
ISSN:	1945-0508
Megjegyzések:	HER2-positive breast cancers represent a distinct phenotype and are intrinsically more aggressive than HER2-negative tumors. Although HER2-targeted therapies have been rationally developed, resistance to these treatments represents a process understood poorly. There are few experimental models that allow studying the molecular mechanism of resistance. Our aim was to characterize a trastuzumab resistant breast cancer cell line (B585) that was established from an invasive ductal carcinoma. B585 grows only in immunodeficient mice as a xenograft. CGH and FISH were used to define cytogenetic alterations, gene-expression analysis and immunohistochemistry were applied to detect RNA and protein expression. By array-CGH focused amplifications were identified for C-MYC, EGFR, ErbB2, CCND1 and TOP2-A oncogenes. ErbB2 was co-amplified with TOP2-A. mRNA overexpression was detected for the amplified genes. ErbB2 protein was overexpressed and showed heterogeneous distribution. In summary, molecular cytogenetic analysis and expression profiling of B585 revealed several new alterations. Based on the experiments performed in SCID mice and the genotypic/phenotypic characteristics, this new in vivo breast cancer xenograft is a valuable model to investigate molecular mechanism of trastuzumab resistance
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk analysis Animals Antibodies Antibodies,Monoclonal Antineoplastic Agents article Biophysics Breast Neoplasms Carcinoma Carcinoma,Ductal,Breast Cell Line Cell Line,Tumor Comparative Genomic Hybridization Disease Models,Animal Drug Resistance,Neoplasm drug therapy EGFR ErbB2 Female Gene Expression Gene Expression Profiling genetics Human Humans Hungary Immunohistochemistry In Situ Hybridization,Fluorescence metabolism Mice Mice,Scid Oncogenes Phenotype Receptor,erbB-2 Research Research Support rna Support therapeutic use therapy Trastuzumab resistance OTKA::1 MAB::3.1
Megjelenés:	Frontiers In Bioscience (elite edition). - 1 : 2 (2010), p. 627-640. -
További szerzők:	Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus) Lázár Viktória (1981-) (molekuláris biológus) Rákosy Zsuzsa (1978-) (sejtbiológus, molekuláris biológus, genetikus) Tóth Enikő Treszl Andrea (1974-) (molekuláris biológus) Vereb György (1965-) (biofizikus, orvos) Colbern, Gail T. Park, John W. Szöllősi János (1953-) (biofizikus)
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001-es BibID:	BIBFORM005174
035-os BibID:	(scopus)38349044364 (wos)000253278400023
Első szerző:	Barok Márk (biofizikus)
Cím:	Trastuzumab decreases the number of circulating and disseminated tumor cells despite trastuzumab resistance of the primary tumor / Márk Barok, Margit Balázs, Péter Nagy, Zsuzsa Rákosy, Andrea Treszl, Enikő Tóth, István Juhász, John W. Park, Jorma Isola, György Vereb, János Szöllősi
Dátum:	2008
ISSN:	304-3835 (Print)
Megjegyzések:	We have recently shown that despite of the fact that the ErbB2-positive JIMT-1 human breast cancer cells intrinsically resistant to trastuzumab in vitro, trastuzumab inhibited the outgrowth of early phase JIMT-1 xenografts in SCID mice via antibody-dependent cellular cytotoxicity (ADCC). Here we show that trastuzumab significantly reduces the number of circulating and disseminated tumor cells (CTCs and DTCs) in this xenograft model system at a time when the primary tumor is already unresponsive to trastuzumab. This observation suggests that ErbB2 positive CTCs and DTCs might be sensitive to trastuzumab-mediated ADCC even if when the primary tumor is already non-responsive. Thus, trastuzumab treatment might also be beneficial in the case of patients with breast cancer that is already trastuzumab resistant.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk analysis Animals antagonists and inhibitors Antibodies Antibodies, Monoclonal Antigens Antigens, CD45 Antineoplastic Agents article Biophysics blood Bone Marrow Breast Neoplasms Cell Line, Tumor Cells Chromosomes, Human,X drug effects Drug Resistance, Neoplasm drug therapy EGFR Epidermal Growth Factor ErbB2 Female genetics Histocompatibility Antigens Histocompatibility Antigens Class I Human Humans Hungary Immunohistochemistry immunology In Situ Hybridization,Fluorescence In Vitro metabolism Mice Mice, Scid mouse Neoplasm Circulating Cells Neoplasm Metastasis pathology pharmacology Receptor, Epidermal Growth Factor Research Research Support Support therapeutic use Time Factors Trastuzumab resistance Xenograft Model Antitumor Assays egyetemen (Magyarországon) készült közlemény
Megjelenés:	Cancer Letters. - 260 : 1-2 (2008), p. 198-208. -
További szerzők:	Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus) Nagy Péter (1971-) (biofizikus) Rákosy Zsuzsa (1978-) (sejtbiológus, molekuláris biológus, genetikus) Treszl Andrea (1974-) (molekuláris biológus) Tóth Enikő Juhász István (1956-) (bőrgyógyász, bőrsebész, kozmetológus, klinikai onkológus) Park, John W. Isola, Jorma Vereb György (1965-) (biofizikus, orvos) Szöllősi János (1953-) (biofizikus)
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001-es BibID:	BIBFORM015973
Első szerző:	Takács Lili (szemész)
Cím:	Differentially Expressed Genes Associated with Human Limbal Epithelial Phenotypes: New Molecules That Potentially Facilitate Selection of Stem Cell-Enriched Populations / Lili Takács, Enikő Tóth, Gergely Losonczy, Attila Szanto, Tomi Bähr-Ivacevic, Vladimir Benes, András Berta, György Vereb
Dátum:	2011
ISSN:	0146-0404
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Molekuláris Medicina
Megjelenés:	Investigative Ophthalmology & Visual Science. - 52 : 3 (2011), p. 1252-1260. -
További szerzők:	Tóth Enikő Losonczy Gergely (1977-) (szemész) Szántó Attila (1976-) (orvos, biokémikus) Bahr-Ivacevic, Tomi Benes, Vladimir Berta András (1955-) (szemész, gyermekszemész) Vereb György (1965-) (biofizikus, orvos)
Pályázati támogatás:	F 046321 OTKA K 75752 OTKA K 68616 OTKA TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP Szaruhártya és retina dystrophis genetikája
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001-es BibID:	BIBFORM010363
Első szerző:	Takács Lili (szemész)
Cím:	Stem cells of the adult cornea : from cytometric markers to therapeutic applications / Takacs, L., Toth, E., Berta, A., Vereb, G.
Dátum:	2009
ISSN:	1552-4922 (Print)
Megjegyzések:	The cornea is a major protective shield of the interior of the eye and represents two thirds of its refractive power. It is made up of three tissue layers that have different developmental origins: the outer, epithelial layer develops from the ectoderm overlying the lens vesicle, whereas the stroma and the endothelium have mesenchymal origin. In the adult organism, the outermost corneal epithelium is the most exposed to environmental damage, and its constant renewal is assured by the epithelial stem cells that reside in the limbus, the circular border of the cornea. Cell turnover in the stromal. layer is very slow and the endothelial cells probably do not reproduce in the adult organism. However, recent experimental evidence indicates that stem cells may be found in these layers. Damage to any of the corneal layers leads to loss of transparency and low vision. Corneal limbal stem cell deficiency results in severe ocular surface disease and its treatment by transplantating ex vivo expanded limbal epithelial cells is becoming widely accepted today. Stromal and endothelial stem cells are potential tools of tissue engineering and regenerative therapies of corneal ulcers and endothelial cell loss. In the past few years, intensive research has focused on corneal stem cells aiming to improve the outcomes of the current corneal stem cell transplantation techniques. This review summarizes the current state of knowledge on corneal epithelial, stromal and endothelial stem cells. Special emphasis is placed on the molecular markers that may help to identify these cells, and the recently revealed mechanisms that could maintain their "stemness" or drive their differentiation. The techniques for isolating and culturing/expanding these cells are also described.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Adult Cells cytometry differentiation Research review stem cell therapy
Megjelenés:	Cytometry. Part A. - 75A : 1 (2009), p. 54-66. -
További szerzők:	Tóth Enikő Berta András (1955-) (szemész, gyermekszemész) Vereb György (1965-) (biofizikus, orvos)
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