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001-es BibID:	BIBFORM004856
Első szerző:	Bagossi Péter (biokémikus, vegyész)
Cím:	Molecular modeling of nearly full-length ErbB2 receptor / Bagossi, P., Horvath, G., Vereb, G., Szollosi, J., Tozser, J.
Dátum:	2005
ISSN:	0006-3495
Megjegyzések:	Members of the epidermal growth factor receptor family play important roles in various cellular processes, both in physiological and in pathological conditions. Dimerization and autophosphorylation of these receptor tyrosine kinases are key events of signal transduction. Details of the molecular events of the signaling are not entirely known. To facilitate the understanding of receptor structure and function at the molecular level, a molecular model was built for the nearly full-length ErbB2 dimer. Modeling was based on the x-ray or nuclear-magnetic resonance structures of extracellular, transmembrane, and intracellular domains. The extracellular domain was positioned above the cell membrane based on the distance determined from experimentally measured fluorescence resonance energy transfer. Favorable dimerization interactions are predicted for the extracellular, transmembrane, and protein kinase domains in the model of a nearly full-length dimer of ErbB2, which may act in a coordinated fashion in ErbB2 homodimerization, and also in heterodimers of ErbB2 with other members of the ErbB family
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban analysis Cell Line, Tumor Cell Membrane chemistry Comparative Study Computer Simulation Dimerization Energy Transfer Epidermal Growth Factor Fluorescence Fluorescence Resonance Energy Transfer Humans Hungary Lipid Bilayers methods Models, Chemical Models, Molecular Neoplasms Protein Conformation Protein Structure, Tertiary Receptor, erbB-2 Research Signal Transduction Structure-Activity Relationship Support ultrastructure
Megjelenés:	Biophysical Journal. - 88 : 2 (2005), p. 1354-1363. -
További szerzők:	Horváth Gábor (1974-) (biofizikus) Vereb György (1965-) (biofizikus, orvos) Szöllősi János (1953-) (biofizikus) Tőzsér József (1959-) (molekuláris biológus, biokémikus, vegyész)
Internet cím:	elektronikus változat
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001-es BibID:	BIBFORM012849
Első szerző:	Csutak Adrienne (szemész)
Cím:	Urokinase down-regulation by aprotinin in rabbit corneal cells after photorefractive keratectomy / Csutak, A., Silver, D. M., Sperka, T., Kádas, J., Vereb, G., Berta, A., Tözsér, J.
Dátum:	2010
Megjegyzések:	aPURPOSE: To examine the effect of aprotinin eye drops on urokinase-type plasminogen activator (uPA) gene expression in rabbit corneal cells during wound healing after photorefractive keratectomy (PRK). METHODS: Both eyes of 22 rabbits were subjected to PRK. One eye of each rabbit was treated with antibiotic eye drops five times while the contralateral eye was treated at the same time with antibiotic eye drops and a serine protease inhibitor. The animals were sacrificed at different time frames, and 2-4 rabbits were used for each time point. Half of each cornea was used for the determination of the amount of uPA mRNA after reverse transcription and real-time quantitative polymerase chain reaction, while frozen sections were prepared from the other halves for in situ zymography to detect uPA activity. RESULTS: The level of uPA mRNA in corneal cells was markedly increased in corneal samples obtained hours after PRK. The time-dependent up-regulation of uPA mRNA was strongly dependent on the diameter of the area from which the epithelial cells were removed before the surgery. Independently of the time scale of uPA up-regulation, application of eye drops containing aprotinin significantly diminished the uPA expression. In situ zymography confirmed that aprotinin has also decreased overall uPA activity. CONCLUSIONS: Aprotinin down-regulates uPA gene expression in corneal cells during the wound-healing phase after PRK
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban administration & dosage Animal Animals Aprotinin article Cells Cornea Down-Regulation drug effects enzymology Gene Expression Gene Expression Regulation, Enzymologic genetics Hungary methods Ophthalmic Solutions Photorefractive Keratectomy Polymerase Chain Reaction Rabbits Research Research Support Reverse Transcriptase Polymerase Chain Reactionrna RNA,Messenger Serine Proteinase Inhibitors Solutions Support time Time Factors Up-Regulation Urokinase-Type Plasminogen Activator Wound Healing OTKA::1 MAB::3.1
Megjelenés:	Current Eye Research. - 35 : 9 (2010), p. 806-811. -
További szerzők:	Silver, David M. Sperka Tamás (1970-) (biokémikus, vegyész, biológia-kémia szakos tanár) Kádas János (1976-) (molekuláris biológus, biokémikus, kertészmérnök) Vereb György (1965-) (biofizikus, orvos) Berta András (1955-) (szemész, gyermekszemész) Tőzsér József (1959-) (molekuláris biológus, biokémikus, vegyész)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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