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001-es BibID:BIBFORM079346
035-os BibID:(cikkazonosító)7213913 (WOS)000464702500001 (Scopus)85065782402
Első szerző:Kiss Rita (laboratóriumi diagnosztika szakorvos)
Cím:Diosgenin and Its Fenugreek Based Biological Matrix Affect Insulin Resistance and Anabolic Hormones in a Rat Based Insulin Resistance Model / Kiss Rita, Pesti-Asbóth Georgina, Szarvas Mária Magdolna, Stündl László, Cziáky Zoltán, Hegedűs Csaba, Kovács Diána, Badale Andrea, Máthé Endre, Szilvássy Zoltán, Remenyik Judit
Dátum:2019
ISSN:2314-6133 2314-6141
Megjegyzések:Fenugreek is known since ancient times as a traditional herbal medicine of its multiple beneficial effects. Fenugreek's most studied and employed effect is its hypoglycemic property, but it can also be useful for the treatment of certain thyroid disorders or for the treatment of anorexia. The regulation of glucose homeostasis is a complex mechanism, dependent on the interaction of different types of hormones and neurotransmitters or other compounds. For the study of how diosgenin and fenugreek seeds modify insulin sensitivity, we used a rat insulin resistance model induced by high-fat diet. Diosgenin in three different doses (1mg/bwkg, 10mg/bwkg, and 50mg/bwkg, respectively) and fenugreek seed (0.2 g/bwkg)were administered orally for 6weeks. Insulin sensitivity was determined by hyperinsulinemic euglycemic glucose clamp method. Our research group found that although glucose infusion rate was not significantly modified in either group, the increased insulin sensitivity index and high metabolic clearance rate of insulin found in the 1 mg/kg diosgenin and the fenugreek seed treated group suggested an improved peripheral insulin sensitivity. Results from the 10 mg/kg diosgenin group, however, suggest a marked insulin resistance. Fenugreek seed therapy results on the investigated anabolic hormones support the theory that, besides insulin and gastrointestinal peptides, the hypothalamichypopituitary axis regulated hormones synchronized action with IGF-1 also play an important role in the maintaining of normal glucose levels. Both diosgenin and fenugreek seeds are capable of interacting with substrates of the above-mentioned regulatory mechanisms, inducing serious hormonal disorders. Moreover, fenugreek seeds showed the ability to reduce the thyroid hormone levels at the periphery and to modify the T4/T3 ratio. It means that in healthy people this effect could be considered a severe side effect; however, in hypothyroidism this effect represents a possibility of alternative natural therapy.
Tárgyszavak:Agrártudományok Élelmiszertudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Diosgenin
Fenugreek
Insulin Resistance
Anabolic Hormones
Rat
Megjelenés:Biomed Research International. - 2019 (2019), p. 1-13. -
További szerzők:Pesti-Asbóth Georgina (1990-) (élelmiszerbiztonsági és -minőségi mérnök) Szarvas Mária Magdolna (1989-) (élelmiszeripari mérnök) Stündl László (1970-) (agrármérnök) Cziáky Zoltán Hegedűs Csaba (1983-) (Molekuláris biológus, Cera-Med Kft. Debrecen) Kovács Diána Klára (1985-) (Molekuláris biológus) Badale, Andrea (1986-) (gyógyszerész) Máthé Endre (1964-) (genetikus, molekuláris sejtbiológus) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Gálné Remenyik Judit (1965-) (kémia tanár, okleveles vegyész)
Pályázati támogatás:EFOP-3.6.2-16-2017-00009
EFOP
Internet cím:Szerző által megadott URL
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2.

001-es BibID:BIBFORM080874
035-os BibID:(cikkazonosító)1966 (WoS)000487964600142 (Scopus)85071503793
Első szerző:Kun-Nemes Andrea (okleveles élelmiszermérnök)
Cím:Effect of Anthocyanin-Rich Tart Cherry Extract on Inflammatory Mediators and Adipokines Involved in Type 2 Diabetes in a High Fat Diet Induced Obesity Mouse Model / Andrea Nemes, Judit Rita Homoki, Rita Kiss, Csaba Hegedűs, Diána Kovács, Barna Peitl, Ferenc Gál, László Stündl, Zoltán Szilvássy, Judit Remenyik
Dátum:2019
ISSN:2072-6643
Megjegyzések:Male C57BL/6J mice were used to determine the possible therapeutic effects of our previously described tart cherry extract in a chronic obesity mouse model on metabolic parameters, glucose tolerance, inflammatory mediators, and antioxidant capacity. The control group received standard mouse chow, and the high fat control group was switched to a high fat diet and tap water supplemented with 5% sucrose. The high fat + anthocyanin group received the high fat and sucrose diet, but received the anthocyanin-rich tart cherry extract dissolved in their drinking water. After six weeks, an oral glucose tolerance test was performed, and the water-soluble antioxidant capacity (ACW), superoxide dismutase (SOD) activity, and the plasma levels of insulin, C-peptide, leptin, IL-6, MCP-1, adiponectin and resistin were measured. The high fat diet increased body weight, reduced glucose tolerance, and caused an elevation in leptin, IL-6, MCP-1, and resistin levels. Furthermore, antioxidant capacity was decreased with a significant elevation of SOD activity. Anthocyanin treatment failed to reverse the effects of the high fat diet on body weight and glucose tolerance, but significantly reduced the leptin and IL-6 levels. The tart cherry extract also made a significant enhancement in antioxidant capacity and SOD activity. Our results show that chronic anthocyanin intake has a potential to enhance redox status and alleviate inflammation associated with obesity.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
sour cherry
anthocyanins
inflammatory mediators
adipokines
obesity
type 2 diabetes
mouse
Megjelenés:Nutrients. - 11 : 9 (2019), p. 1-17. -
További szerzők:Homoki Judit (1978-) (biológus) Kiss Rita (1974-) (laboratóriumi diagnosztika szakorvos) Hegedűs Csaba (1983-) (Molekuláris biológus, Cera-Med Kft. Debrecen) Kovács Diána Klára (1985-) (Molekuláris biológus) Peitl Barna (1972-) (orvos, farmakológus) Gál Ferenc (1964-) (élelmiszertechnológia) Stündl László (1970-) (agrármérnök) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Gálné Remenyik Judit (1965-) (kémia tanár, okleveles vegyész)
Pályázati támogatás:EFOP-3.6.2-16-2017-00009
EFOP
ÚNKP 20428-3/2018/FEKUTSTRAT
egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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