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001-es BibID:BIBFORM001297
035-os BibID:(Wos)000222590300004 (Scopus)2442668507
Első szerző:Röszer Tamás (orvos, biológus)
Cím:Structural diversity of NADPH diaphorase-reactive enteral networks in Stylommatophora (Gastropoda, Pulmonata) / Tamás Röszer, Zsolt Jenei, Zoltán Serfözö, Zsolt Czimmerer, Gáspár Bánfalvi
Dátum:2004
Megjegyzések:In this work we investigated the involvement of putative nitric oxide (NO)-forming neurons in enteric plexuses of stylommatophoran gastropods. The nitric oxide synthase (NOS)-containing cells were detected by NADPH diaphorase (NADPHd) histochemistry in the entreral nervous systems of several stylommatophoran species (Achatinacea: Achatina fulica, Helicacea: Cepaea hortensis, Cepaea nemoralis, Discus rotundatus, Helicella obvia, Helix lucorum, Helix lutescens, Monachoides umbrosa, Trichia hispida, Zebrina detrita, Succineacea: Succinea putris, Vertiliginacea: Clausilia dubia, Zonitacea: Arion ater, Arion subfuscus, Limax maximus). We detected the NO synthesis of isolated midintestinal segments by Griess's quantification of nitrite, one end product of NO. Effects of the NOS substrate L-arginine and the NOS inhibitor N?-nitro-L-arginine (NOARG) were also tested on nitrite production. We found NADPHd-reactive neurons and extrinsic nerves with NADPHd-stained fibers within the myenteric and submucosal networks of the midintestine of investigated members of Helicacea, Succineacea, and Vertiliginacea families. These networks innervated the midintestinal musculature and several nerve cells of the myenteric and submucosal plexi. In investigated members of Achatinacea and Zonitacea, NADPHd-stained networks were not detectable within the digestive tract. Administration of 1 mM L-arginine elevated, whereas 2 mM of NOARG diminished, the nitrite levels of the NADPHd-stained networks containing midintestine in C. nemoralis and H. lucorum. Enteral NADPHd staining was not detected in A. ater and L. maximus, and the nitrite production was not affected by L-arginine. Our results indicate a possible, but evolutionarily not conserved, NO-mediated enteral transmission in stylommatophoran gastropods.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
NADPH diaforáz
nitrogénmonoxid szintáz
enterális idegrendszer
lábasfejűek
Megjelenés:Invertebrate Biology. - 123 : 2 (2004), p. 128-135. -
További szerzők:Jenei Zsolt Serfőző Zoltán Czimmerer Zsolt (1981-) (molekuláris biológus) Bánfalvi Gáspár (1943-) (sejtbiológus, gyógyszerész)
Internet cím:elektronikus változat
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2.

001-es BibID:BIBFORM001290
035-os BibID:(Wos)000187210800003 (Scopus)0348010590
Első szerző:Röszer Tamás (orvos, biológus)
Cím:A possible stimulatory effect of FMRFamide on neural nitric oxide production in the central nervous system of Helix lucorum L. / Tamás Röszer, Zsolt Jenei, Tamás Gáll, Olivér Nagy, Zsolt Czimmerer, Zoltán Serfözö, Károly Elekes, Gáspár Bánfalvi
Dátum:2004
Megjegyzések:The anatomical and functional relationship between neurons expressing nitric oxide (NO) synthase and molluscan cardioexcitatory (FMRFamide)-like neuropeptides was studied in the central ganglia of Helix lucorum (Pulmonata, Gastropoda), applying NADPHdiaphorase (NADPHd) histochemistry to visualize NO synthase and immunocytochemistry to demonstrate FMRFamide (FMRFa) at the light microscopic level. The NO production of the ganglia was detected by the colorimetric Griess determination of nitrite, a breakdown product of NO. Effects of the NO synthase substrate amino acid L-arginine, the NO synthase inhibitor Nomega-nitro-L-arginine (NOARG), synthetic FMRFa and the FMRFa sensitive ion channel blocker amiloride hydrochloride on nitrite production were also tested. NADPHd reaction labeled nerve cells and fibers in the procerebra, mesocerebra and metacerebra within the cerebral ganglia, and cell clusters in the postcerebral ganglia. FMRFa immunolabeling could be observed within subpopulations of NADPHd positive cells and in pericellular varicose fibers surrounding NADPHd stained neurons. Nitrite production of the ganglia was stimulated by L-arginine (10- 20 mM) but was decreased by NOARG (1-2 mM). Synthetic FMRFa (0.830-3.340 mM) increased the nitrite production in a dose dependent manner, but was ineffective in the presence of NOARG. Amiloride hydrochloride (7.890 mM) reduced the FMRFa evoked nitrite production in all ganglia. This is the first description of an anatomical relationship between putative NO producing and FMRFa containing cells, suggesting a possible regulatory role of FMRFa in the NO mediated signaling in an invertebrate nervous system. Copyright 2004 S. Karger AG, Basel
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
FMRFamid
nitrogén monoxid
neurokémia
gerinctelenek
fejlábúak
éticsiga
Megjelenés:Brain, Behavior and Evolution. - 63 : 1 (2004), p.23-33. -
További szerzők:Jenei Zsolt Gáll Tamás Nagy Olivér Czimmerer Zsolt (1981-) (molekuláris biológus) Serfőző Zoltán Elekes Károly Bánfalvi Gáspár (1943-) (sejtbiológus, gyógyszerész)
Internet cím:elektronikus változat
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