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001-es BibID:	BIBFORM074228
Első szerző:	Fülöp Tibor (kardiológus)
Cím:	Adaptation of Vasomotor Function of Human Coronary Arterioles to the Simultaneous Presence of Obesity and Hypertension / Tibor Fulop, Eva Jebelovszki, Nora Erdei, Tamas Szerafin, Tamas Forster, Istvan Edes, Akos Koller, Zsolt Bagi
Dátum:	2007
ISSN:	1079-5642
Megjegyzések:	Objectives: We hypothesized that simultaneous presence of obesity and hypertension activates adaptive vascular mechanisms affecting dilations of human coronary arterioles.Methods and Results: Agonist-induced dilations were assessed in isolated pressurized coronary arterioles from patients(n 38) who underwent cardiac surgery. Among normotensives we found that dilations to bradykinin (BK) and the NO-donor, sodium-nitroprusside (SNP) were reduced in obese subjects (BK, 10 7 mol/L, lean:90 4%, obese:64 7%; SNP, 10 6 mol/L, lean:89 7%, obese:76 5%). However, among hypertensives, both BK- and SNP-induced dilations were significantly enhanced in obese patients, when compared with lean individuals (BK, lean:71 7%, obese:85 3%; SNP, lean:60 6%, obese:83 2%). Correspondingly, in hypertensive patients, but not in those of normotensives, a positive correlation was found between body mass index (BMI) and BK-induced (P 0.036, r 0.46), and also SNP-evoked (P 0.031, r 0.44) coronary dilations. Moreover, in additional 55 hypertensive patients flow-mediated (FMD) and nitroglycerin (NTG)-induced dilations of the brachial artery were assessed. In obese hypertensive individuals, FMD- and NTG-induced dilations were greater (FMD:6.2 0.7%, NTG:17.2 0.9%), than in leanhypertensive patients (FMD:3.7 0.6%, NTG:13.6 1.1%). Correspondingly, FMD- and NTG-induced dilations were positively correlated with BMI (P 0.020, r 0.31 and P 0.033, r 0.29, respectively).Conclusions:These findings are the first to suggest that obesity may lead to activation of adaptive vascular mechanisms to enhance the dilator function of coronary and peripheral arterial vessels in hypertensive patients. (Arterioscler Thromb Vasc Biol. 2007;27:2348-2354.)
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban obesity hypertension coronary microcirculation flow-mediated dilation nitrate
Megjelenés:	Arteriosclerosis Thrombosis And Vascular Biology. - 27 : 11 (2007), p. 2348-2354. -
További szerzők:	Jebelovszki Éva Erdei Nóra (1979-) (orvos) Szerafin Tamás (1960-) (szívsebész, mellkassebész) Forster Tamás Édes István (1952-) (kardiológus) Koller Ákos Bagi Zsolt (1974-) (orvos)
Pályázati támogatás:	F-048837 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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