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001-es BibID:BIBFORM017942
035-os BibID:PMID: 21709636
Első szerző:Kiss Levente
Cím:Human internal thoracic artery grafts exhibit severe morphological and functional damage and spasmic vasomotion due to oxidative stress / Levente Kiss, Rita Benkő, Endre Kovács, Tamás Szerafin, Katalin Módis, Csaba Szabó, Zsombor Lacza
Dátum:2011
ISSN:1234-1010
Megjegyzések:BACKGROUND: The internal thoracic artery (ITA) is the first choice for myocardial revascularization, but atherosclerotic lesions and perioperative vasospasm may still limit its functionality. Oxidative stress via the peroxynitrite - poly-(ADP-ribose) polymerase (PARP) cascade plays an important role in the pathogenesis of impaired vascular tone via endothelial injury. We aimed to investigate and describe the histology, PARP activation and functionality of ITA grafts and to assess the possible beneficial effect of PARP-inhibition. MATERIAL/METHODS: ITA specimens from 47 patients (26 men, mean age 66.2 ± 1.7 years) who underwent coronary bypass surgery were processed for histological and immunohistochemical studies for oxidative stress and PARP activation, and were functionally tested with acetylcholine (ACh) and sodium nitroprusside (SNP) with or without PARP inhibition. RESULTS: The sections showed atherosclerotic alterations and oxidative and nitrosative stress were evidenced by positive 3-nitrotyrosine, 4-hydroxynonenal and PAR stainings. Functionally, 88.1% reacted to K-Krebs, 68.7% exhibited contraction after 1 mikroM phenylephrine, 29.9% exhibited relaxation to 30 mikroM Ach, and all precontracted segments relaxed to 30 mikroM SNP. High amplitude vasomotion was observed in 47.8% of the segments, which could be abolished by the application of 10 mikroM SNP.Incubation of the preparations with PJ34 did not improve endothelium-dependent vasodilation. CONCLUSIONS: ITA grafts are severely damaged both morphologically and functionally in patients undergoing coronary artery bypass surgery, but PARP inhibition cannot improve their functional characteristics. The topical use of SNP to the ITA during the operation may improve vascular functions by dilating the vessels and eliminating the eventual spasmic vasomotion
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Medical Science Monitor 17 : 7 (2011), p. CR411-CR416. -
További szerzők:Benkő Rita Kovács Endre Szerafin Tamás (1960-) (szívsebész, mellkassebész) Módis Katalin Szabó Csaba Lacza Zsombor
Pályázati támogatás:TÁMOP-4.2.2-08/1/KMR-2008-0004
TÁMOP
TÁMOP-4.2.1/B-09/1/KMR-2010-0001
TÁMOP
PD 83803
OTKA
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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